ID G1QLK5_NOMLE Unreviewed; 1786 AA.
AC G1QLK5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Kinesin family member 13A {ECO:0000313|Ensembl:ENSNLEP00000001820.2};
GN Name=KIF13A {ECO:0000313|Ensembl:ENSNLEP00000001820.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000001820.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000001820.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000001820.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR EMBL; ADFV01015913; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01015914; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01015915; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01015916; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01015917; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01015918; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01015919; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01015920; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01015921; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01015922; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSNLET00000001924.2; ENSNLEP00000001820.2; ENSNLEG00000001201.2.
DR eggNOG; KOG0241; Eukaryota.
DR GeneTree; ENSGT00940000157508; -.
DR HOGENOM; CLU_001485_29_2_1; -.
DR TreeFam; TF105221; -.
DR Proteomes; UP000001073; Chromosome 8.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd22729; FHA_KIF13A; 1.
DR CDD; cd01365; KISc_KIF1A_KIF1B; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 6.10.250.2520; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR022164; Kinesin-like.
DR InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR InterPro; IPR032405; Kinesin_assoc.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR47117; STAR-RELATED LIPID TRANSFER PROTEIN 9; 1.
DR PANTHER; PTHR47117:SF1; STAR-RELATED LIPID TRANSFER PROTEIN 9; 1.
DR Pfam; PF12473; DUF3694; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF12423; KIF1B; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF16183; Kinesin_assoc; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 1..333
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REGION 537..556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 614..637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1410..1429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1489..1512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1593..1628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1730..1759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 345..390
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 537..552
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 615..637
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1593..1627
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1734..1759
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 83..90
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1786 AA; 200149 MW; 9C17EC6650788561 CRC64;
LELNTKCVVE MEGNQTVLHP PPSNTKQGER KPPKVFAFDY CFWSMDESNT TKYAGQEVVF
KCLGEGILEK AFQGYNACIF AYGQTGSGKS FSMMGHAEQL GLIPRLCCAL FKRISLEQNE
SQTFKVEVSY MEIYNEKVRD LLDPKGSRQS LKVREHKVLG PYVDGLSQLA VTSFEDIESL
MSEGNKSRTV AATNMNEESS RSHAVFNIII TQTLYDLQSG NSGEKVSKVS LVDLAGSERV
SKTGAAGERL KEGSNINKSL TTLGLVISSL ADQAAGKGKS KFVPYRDSVL TWLLKDNLGG
NSQTSMIATI SPAADNYEET LSTLRYADRA KRIVNHAVVN EDPNAKVIRE LREEVEKLRE
QLSQAEAMKA PELKEKLEES EKLIKELTVT WEEKLRKTEE IAQERQRQLE SMGISLEMSG
IKVGDDKCYL VNLNADPALN ELLVYYLKDH TRVGADTSQD IQLFGIGIQP EHCEIDIASD
GDVSLTPKEN ARSCVNGTLV CSTTQLWHGD RILWGNNHFF RINLPKRKRR DWLKDFEKET
GPPEHDLDAA SEASSEPDYN YEFAQMEVIM KTLNSNDPVQ NVVQILEKQY LEEKRSALEE
QRLMYERELE QLRQQLSPDR QPQSSGPDRL AYSSQTAQQK VTQWAEERDE LFRQSLAKLR
EQLVKANTLV REANFLAEEM SKLTDYQVTL QIPAANLSAN RKRGAIVSEP AIQVRRKGKS
TQVWTIEKLE NKLIDMRDLY QEWKEKVPEA KRLYGKRGDP FYEAQENHNL IGVANVFLEC
LFCDVKLQYA VPIISQQGEV AGRLHVEVMR VTGAVPERVV EDDSSENSSE SGSLEVVDSS
GEIIHRVKKL TCRVKIKEAT GLPLNLSNFV FCQYTFWDQC ESTVAAPVVD PEVPSPQSKD
AQYTVTFSHC KDYVVNVTEE FLEFISDGAL AIEVWGHRCA GNGSSIWEVD SLHAKTRTLH
DRWNEVTRRI EMWISILELN ELGEYAAVEL HQAKDVNTGG IFQLRQGHSR RVQVTVKPVQ
HSGTLPLMVE AILSVSIGCV TARSTKLQRG LDSYQRDDED GDDMDSYQEE DLNCVRERWS
DALIKRREYL DEQIKKVSNK TEKTEDDVER EAQLVEQWVG LTEERNAVLV PAPGSGIPGA
PADWIPPPGM ETHIPVLFLD LNADDLSANE QLVGPHASGV NSILPKEHGS QFFYLPIIKH
SDDEVSATAS WDSSVHDSVH LNRVTPQNER IYLIVKTTVQ LSHPAAMELV LRKRIAANIY
NKQSFTQSLK RRISLKNILY SCGVTYEIVS NIPKATEEIE DRETLALLAA RSENEGTSDG
ETYIEKYTRG VLQVENILSL ERLRQAVTVK EALSTKARHI RRSLSTPNVH NVSSSRPDLS
GFDEDDKGWP ENQLDMSDYS SSYQDVACYG TLPRDSPRRN KEGCTSETPH ALTISPFKAF
SPQPPKFFKP LMPVKEEHKK RIALEARPLL SQESMPPPQA HNPGCIVPSG SNGSSMPVEH
NSKREKKIDS EEEENELEAI NRKLISSQPY VPVEFADFSV YNASLENREW FSSKVDLSNS
RVLEKEVSRS PTTSSITSGY FSHSASNATL SDMVVPSSDS SDQLAIQAKD ADSTEHSTPS
LVHDFRPSSN KELTEVEKAL VKDKIIMVPL KENSALAKGS PSSQSIPEKI SKSLCRTGSC
SELDACPSKI SQPARVFCPR EVTVEHTTNI LEDHSFTEFM GVSEGKDFDG LTDSSAGELS
SRRNLPNKTG SKTVSDGLHH PSQLHSKLEN DQVIIPEAAF WVLCCQ
//
