ID G1QPI3_NOMLE Unreviewed; 235 AA.
AC G1QPI3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=HscB mitochondrial iron-sulfur cluster cochaperone {ECO:0000313|Ensembl:ENSNLEP00000002849.1};
GN Name=HSCB {ECO:0000313|Ensembl:ENSNLEP00000002849.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000002849.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000002849.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000002849.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the HscB family.
CC {ECO:0000256|ARBA:ARBA00010476}.
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DR EMBL; ADFV01177461; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01177462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003258081.1; XM_003258033.3.
DR AlphaFoldDB; G1QPI3; -.
DR STRING; 61853.ENSNLEP00000002849; -.
DR Ensembl; ENSNLET00000002997.3; ENSNLEP00000002849.1; ENSNLEG00000002360.3.
DR GeneID; 100592836; -.
DR KEGG; nle:100592836; -.
DR CTD; 150274; -.
DR eggNOG; KOG3192; Eukaryota.
DR GeneTree; ENSGT00390000008206; -.
DR HOGENOM; CLU_068529_0_2_1; -.
DR InParanoid; G1QPI3; -.
DR OMA; LMFIERF; -.
DR OrthoDB; 5473494at2759; -.
DR TreeFam; TF319992; -.
DR Proteomes; UP000001073; Chromosome 7b.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0001671; F:ATPase activator activity; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0051087; F:protein-folding chaperone binding; IEA:InterPro.
DR GO; GO:0044571; P:[2Fe-2S] cluster assembly; IEA:InterPro.
DR GO; GO:0051259; P:protein complex oligomerization; IEA:InterPro.
DR Gene3D; 1.10.287.110; DnaJ domain; 1.
DR Gene3D; 1.20.1280.20; HscB, C-terminal domain; 1.
DR HAMAP; MF_00682; HscB; 1.
DR InterPro; IPR004640; HscB.
DR InterPro; IPR040682; HscB_4_cys.
DR InterPro; IPR036386; HscB_C_sf.
DR InterPro; IPR009073; HscB_oligo_C.
DR InterPro; IPR036869; J_dom_sf.
DR NCBIfam; TIGR00714; hscB; 1.
DR PANTHER; PTHR14021; IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB; 1.
DR PANTHER; PTHR14021:SF15; IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB; 1.
DR Pfam; PF18256; HscB_4_cys; 1.
DR Pfam; PF07743; HSCB_C; 1.
DR SUPFAM; SSF46565; Chaperone J-domain; 1.
DR SUPFAM; SSF47144; HSC20 (HSCB), C-terminal oligomerisation domain; 1.
PE 3: Inferred from homology;
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 39..65
FT /note="HscB tetracysteine metal binding motif"
FT /evidence="ECO:0000259|Pfam:PF18256"
FT DOMAIN 157..229
FT /note="Co-chaperone HscB C-terminal oligomerisation"
FT /evidence="ECO:0000259|Pfam:PF07743"
SQ SEQUENCE 235 AA; 27426 MW; 96114A1DC52195CD CRC64;
MWRGRAGALL RVWGFWPTGV PRRRPLSCDA ASQAGSNYPR CWNCGGPWGP RREDRFFCPQ
CRALQAPDPT RDYFSLMDCN RSFRVDTAKL QHRYQQLQRL VHPDFFSQRS QTEKDFSEKH
STLVNDAYKT LLAPLSRGLY LLKLHGVEIP EGTDYEMDRQ FLMEIMEINE KLAEAESEAA
MKEIESIVKA KQKEFTDNVS SAFEQDDFEE AKEILTKMRY FSNIEEKIKL KKIPL
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