ID G1QRU3_NOMLE Unreviewed; 1133 AA.
AC G1QRU3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=DExH-box helicase 34 {ECO:0000313|Ensembl:ENSNLEP00000003661.2};
GN Name=DHX34 {ECO:0000313|Ensembl:ENSNLEP00000003661.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000003661.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000003661.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000003661.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01102318; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01102319; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01102320; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01102321; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01102322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01102323; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01102324; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01102325; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01102326; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1QRU3; -.
DR Ensembl; ENSNLET00000003844.3; ENSNLEP00000003661.2; ENSNLEG00000003010.3.
DR eggNOG; KOG0922; Eukaryota.
DR GeneTree; ENSGT00940000158721; -.
DR HOGENOM; CLU_001832_5_2_1; -.
DR TreeFam; TF313217; -.
DR Proteomes; UP000001073; Chromosome 17.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd17979; DEXHc_DHX34; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF148; ATP-DEPENDENT RNA HELICASE DHX34-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022806};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 172..332
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 368..536
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 75..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 714..755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 714..741
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1133 AA; 126968 MW; 3AC35173B4503D0B CRC64;
MPPPRTREGR DRRDHHRAPS EEEALEKWDW NCPETRRLLE DAFFREEDYI RQGSEECQKF
WTFFERLQRF QNLRTSRKEE KDPGQPKHSI PALADLPRTY DPRYRINLSV LGPDTRGSQG
LSRHLPAERV AEFRRALLHY LDFGQKQAFG RLAKLQHERA ALPIAQYGNR ILQTLEEHQV
VVVAGDTGCG KSTQVPQYLL AAGFSHVACT QPRRIACISL AKRVGFESLS QYGSQVGYQI
RFESTRSAAT KIVFLTVGLL LRQIQREPSL PQYEVLIVDE VHERHLHNDF LLGVLRRLLP
TRPDLKVILM SATINISLFS SYFSNAPVVQ VPGRLFPITV VYQPQEVEPT TSKSEKLDPR
PFLRVLESID HKYPPEERGD LLVFLSGMAE ISAVLEATQT YASHTQRWVV LPLHSALSVA
DQDKVFDVAP PGVRKCILST NIAETSVTID GIRFVVDSGK VKEMSYDPQA KLQRLQEFWI
SQASAEQRKG RAGRTGPGVC FRLYAESDYD AFAPYPVPEI RRVALDSLVL QSMSVGDPRT
FPFIEPPPPA ILETAILYLR DQGALDRARA APVLAPRSLS PVSAAPGKML ILGSMFSLVE
PVLTIAAALS VQSPFTRSAQ SSPECAAARR PLRTPCGASG DPVYVKSERS RNSRKWCRRR
GIEEHRLYEM ANLRRQFKEL LEDHRLLAGA QAAQVGDSYS RLQQRRERRA LHQLKRQHEE
GAGRRRKVLR LQEEQDGGSS DEDRAGPALP GASDGVDIQD VKFKLRHDLA QLQAAASSAQ
DLSREQLVLL KLVLGRGLYP QLAVPDAFNS SRKDSDQIFH TQAKQGAVLH PTCVFAGSPQ
VLHAQELEAS SCDGSRDDKD KMISKHQLLS FVSLLETNKP YLVNCVRIPA LQSLLLFSRS
LDTNGDCSRL VADSWLELQL ADSESAIRLL AASLQLRARW ESALDRQLAH QAQRRLEEEE
QDAPVSPKEV ATLSKELLQF TASKIPYSLR RLTGLEAQNM YVGPQTIPAT PHLPGLFGSS
TLSPHPTKGG YAVTDFLTYN CLTSDTDLYS DCLRTFWTCP HCGLHAPLTP LERIAHENTC
PQAPQGGPPG AEEAAPETLQ KTSVLQRPYH CEACGKDFLF TPTEVLRHRK QHV
//
