ID G1QTB5_NOMLE Unreviewed; 916 AA.
AC G1QTB5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Inner centromere protein {ECO:0000313|Ensembl:ENSNLEP00000004183.2};
GN Name=INCENP {ECO:0000313|Ensembl:ENSNLEP00000004183.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000004183.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000004183.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000004183.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}. Cytoplasm, cytoskeleton, spindle
CC {ECO:0000256|ARBA:ARBA00004186}. Midbody
CC {ECO:0000256|ARBA:ARBA00004214}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the INCENP family.
CC {ECO:0000256|ARBA:ARBA00010042}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ADFV01079109; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01079110; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003274118.1; XM_003274070.3.
DR AlphaFoldDB; G1QTB5; -.
DR Ensembl; ENSNLET00000004401.2; ENSNLEP00000004183.2; ENSNLEG00000003380.2.
DR GeneID; 100601658; -.
DR CTD; 3619; -.
DR eggNOG; KOG4456; Eukaryota.
DR GeneTree; ENSGT00730000111073; -.
DR HOGENOM; CLU_015997_0_0_1; -.
DR OrthoDB; 3094173at2759; -.
DR TreeFam; TF101172; -.
DR Proteomes; UP000001073; Chromosome 4.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.3600; -; 1.
DR Gene3D; 6.10.250.2990; -; 1.
DR InterPro; IPR022006; INCENP_N.
DR InterPro; IPR005635; Inner_centromere_prot_ARK-bd.
DR PANTHER; PTHR13142; INNER CENTROMERE PROTEIN; 1.
DR PANTHER; PTHR13142:SF1; INNER CENTROMERE PROTEIN; 1.
DR Pfam; PF03941; INCENP_ARK-bind; 1.
DR Pfam; PF12178; INCENP_N; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Chromosome partition {ECO:0000256|ARBA:ARBA00022829};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 6..41
FT /note="Chromosome passenger complex (CPC) protein INCENP N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12178"
FT DOMAIN 823..879
FT /note="Inner centromere protein ARK-binding"
FT /evidence="ECO:0000259|Pfam:PF03941"
FT REGION 49..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 139..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 372..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 528..561
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 605..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 658..738
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 752..843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..84
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..218
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..463
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 752..783
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 789..807
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 916 AA; 105196 MW; F4CEF4935F710862 CRC64;
MGTTAPGPIH LLELCDQKLM EFLCNMDNKD LVWLEEIQEE AERMFTREFS KEPELMPKTP
SQKNRRKKRR ISYVQDENRD PVRRRLSRRK SRTSQLSSRR LRSKDSVEKL ATMVGENGSV
LRRVTRAAAA AAAAAATVAL AAPSSPTPES PTMLTKKPED NHTQCQLVPV VEIGISERQN
AEQHVTQLVS AQPLPRTLSP TPASATAPAS QGILTSDEES TPKKSKARIL ESITVSSLMA
TPQDPKGRGV GTGRSASKLR IAQVSPGPRD SPASPDSPWR ERVLAPILPD NFSTPTGSRT
DSQSVRRSPI APSSPSPQVL AQKYSLVAKQ ESVVRRASRR LAKKTAEEPA ASGRIICHSY
LERLLNVEVP QKVGSEQKEP SEEAEPVVAA EPEVPENNGN NSWPRNEAEI ANSTPNPKPA
ASSPETPSAG QQEAKTDQAD GPREPPQSAR RKRSYKQAVS ELDEEQHLED EELQPPRSKT
PSSPCRASKV VRPLRTFLHT VQRNQMLMTP TSAPRSVMKS FIKRNTPLRM DPKEKERQRL
ENLRRKEEAE QLRRQKVEED KRRRLKEVKL KREERLRKVL QARERVEQMK EEKKKQIEQK
FAQIDEKTEK AKEERLAEEK AKKKAAAKKM EEVEARRKQE EEARRLRWLQ QEEEERRHQE
LLQKKKEEEQ ERLRKAAEAK RLAEQREQER REQERREQER REQERREQER REQERQLAEQ
ERRREQERLQ AERELQEREK ALRLQKERLQ KELEEKKKKE EQQRLAERQL QEEQEKKAKE
AAEASKALNV TVDVQSPACT SYQMTPQGHR APPKINPDNY GMDLNSDDST DDEAHPRKPI
PTWARGTPLS QAIIHQYYHP PNLLELFGTI LPLDLEDIFK KSKPRYHKRT SSAVWNSPPL
QGARVPSSLA YSLKKH
//