GenomeNet

Database: UniProt
Entry: G1QTU4_NOMLE
LinkDB: G1QTU4_NOMLE
Original site: G1QTU4_NOMLE 
ID   G1QTU4_NOMLE            Unreviewed;      3466 AA.
AC   G1QTU4;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   30-AUG-2017, entry version 42.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSNLEP00000004362};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSNLEP00000004362};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates
OS   leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hylobatidae; Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000004362};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000004362}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000004362}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSNLEP00000004362}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ADFV01037083; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01037084; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01037085; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01037086; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01037087; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01037088; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01037089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01037090; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01037091; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01037092; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 61853.ENSNLEP00000004362; -.
DR   Ensembl; ENSNLET00000004591; ENSNLEP00000004362; ENSNLEG00000003602.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; G1QTU4; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000001073; Unplaced.
DR   GO; GO:0034704; C:calcium channel complex; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0043234; C:protein complex; IEA:Ensembl.
DR   GO; GO:0016529; C:sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IEA:Ensembl.
DR   GO; GO:0005516; F:calmodulin binding; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0034236; F:protein kinase A catalytic subunit binding; IEA:Ensembl.
DR   GO; GO:0034237; F:protein kinase A regulatory subunit binding; IEA:Ensembl.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0043924; F:suramin binding; IEA:Ensembl.
DR   GO; GO:0035584; P:calcium-mediated signaling using intracellular calcium source; IEA:Ensembl.
DR   GO; GO:0060048; P:cardiac muscle contraction; IEA:Ensembl.
DR   GO; GO:0071313; P:cellular response to caffeine; IEA:Ensembl.
DR   GO; GO:0005513; P:detection of calcium ion; IEA:Ensembl.
DR   GO; GO:0072599; P:establishment of protein localization to endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:1901896; P:positive regulation of calcium-transporting ATPase activity; IEA:Ensembl.
DR   GO; GO:0051284; P:positive regulation of sequestering of calcium ion; IEA:Ensembl.
DR   GO; GO:0098735; P:positive regulation of the force of heart contraction; IEA:Ensembl.
DR   GO; GO:0098910; P:regulation of atrial cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0098904; P:regulation of AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0010882; P:regulation of cardiac muscle contraction by calcium ion signaling; IEA:Ensembl.
DR   GO; GO:0002027; P:regulation of heart rate; IEA:Ensembl.
DR   GO; GO:0098907; P:regulation of SA node cell action potential; IEA:Ensembl.
DR   GO; GO:0098911; P:regulation of ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0014850; P:response to muscle activity; IEA:Ensembl.
DR   GO; GO:0035994; P:response to muscle stretch; IEA:Ensembl.
DR   GO; GO:0051775; P:response to redox state; IEA:Ensembl.
DR   GO; GO:0097050; P:type B pancreatic cell apoptotic process; IEA:Ensembl.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 1.
DR   Pfam; PF02026; RyR; 2.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001073};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2780   2799       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3000   3020       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3074   3093       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3267   3288       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3343   3366       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        1     63       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     2524   2559       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     2912   2945       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   3466 AA;  395522 MW;  D2DF7C9A1FA95A41 CRC64;
     KNNMVLEIGC VIXXXXXLLT FIANGKELST YYQVEPSTKL FPAVFAQATS PNVFQFELGR
     IKNVMPLSAG LFKSEHKNPV PQCPPRLHVQ FLSHVLWSRM PNQFLKVDVS RISERQGWLV
     QCLDPLQFMS LHIPEENRSV DILELTEQEE LLKFHYHTLR LYSAVCALGN HRVAHALCSH
     VDEPQLLYAI ENKYMPGLLR AGYYDLLIDI HLSSYATARL MMNNEYIVPM TEETKSITLF
     PDENKKHGLP GIGLSTSLRP RMQFSSPSFV SISNECYQYS PEFPLDILKA KTIQMLTEAV
     KEGSLHARDP VGGTTEFLFV PLIKLFYTLL IMGIFHNEDL KHILQLIEPS VFKEAATPEE
     ESDTLEKEFS VDDAKLQGAG EEEAKGGKRP KEGLLQMKLP EPVKLQMCLL LQYLCDCQVR
     HRIEAIVAFS DDFVAKLQDN QRFRYNEVMQ ALNMSAALTA RKTKEFRSPP QEQINMLLNF
     KDDKSECPCP EEIRDQLLDF HEDLMTHCGI ELDEDGSLDG NSDLTIRGRL LSLVEKVTYL
     KKKQAEKPVE SDSKKSSTLQ QLISETMVRW AQESVIEDPE LVRAMFVLLH RQYDGIGGLV
     RALPKTYTIN GVSVEDTINL LASLGQIRSL LSVRMGKEEE KLMIRGLGDI MNNKVFYQHP
     NLMRALGMHE TVMEVMVNVL GGGESKEITF PKMVANCCRF LCYFCRISRQ NQKAMFDHLS
     YLLENSSVGL ASPAMRGSTP LDVAAASVMD NNELALALRE PDLEKVVRYL AGCGLQSCQM
     LVSKGYPDIG WNPVEGXXXX XXXXXXXSTL GESVEENANV VVRLLIRRPE CFGPALRGEG
     GNGLLAAMEE AIKIAEDPSR DGPSPNSGST KTLDTEEEED DTIHMGNAIM TFYAALIDLL
     GRCAPEMHLI HAGKGEAIRI RSILRSLIPL GDLVGVISIA FQMPTIAKDG NVVEPDMSAG
     FCPDHKAAMV LFLDRVYGIE VQDFLLHLLE VGFLPDLRAA ASLDTAALSA TDMALALNRY
     LCTAVLPLLT RCAPLFAGTE HHASLIDSLL HTVYRLSKGC SLTKAQRDSI EVCLLSICGQ
     LRPSMMQHLL RRLVFDVPLL NEHAKMPLKL LTNHYERCWK YYCLPGGWGN FGAASEEELH
     LSRKLFWGIF DALSQKKYEQ ELFKLALPCL SAVAGALPPD YMESNYVSMM EKQSSMDSEG
     NFNPQPVDTS NITIPEKLEY FINKYAEHSH DKWSMDKLAN GWIYGEIYSD SSKVQPLMKP
     YKLLSEKEKE IYRWPIKESL KTMLAWGWRI ERTREGDSMA LYNRTRRISQ TSQVSVDAAH
     GYSPRAIDMS NVTLCRDLHA MAEMMAENYH NIWAKKKKME LESKGGGNHP LLVPYDTLTA
     KEKAKDREKA QDILKFLQIN GYAVSRGFKD LELDTPSIEK RFAYSFLQQL IRYVDEAHQY
     ILEFDGGSRG KGEHFPYEQE IKFFAKVVLP LIDQYFKNHR LYFLSAASRP LCSGGHASNK
     EKEMVTSLFC KLGVLVRHRI SLFGNDATSI VNCLHILGQT LDARTVMKTG LESVKSALRA
     FLDNAAEDLE KTMENLKQGQ FTHTRNQPKG VTQIINYTTV ALLPMLSSLF EHIGQHQFGE
     DLILEDVQVS CYRILTSLYA LGTSKSIYVE RQRSALGECL AAFAGAFPVA FLETHLDKHN
     IYSIYNTKSS RERAALSLPT NVEDVCPNIP SLEKLMEEIV ELAESGIRYT QMPHVMEVIL
     PMLCSYMSRW WEHGPENNPE RAEMCCTALN SEHMNTLLGN ILKIIYNNLG IDEGAWMKRL
     AVFSQPIINK VKPQLLKTHF LPLMEKLKKK AAMVVSEEDH LKAEARGDMS EAELLILDEF
     TTLARDLYAF YPLLIRFVDY NRAKWLKEPN PEAEQLFRMV AEVFIYWSKS HNFKREEQNF
     VVQNEINNMS FLITDTKSKM SKAAVSDQER KKMKRKGDRY SMQTSLIVAA LKRLLPIGLN
     ICAPGDQELI ALAKNRFSLK DTEDEVRDII RSNIHLQGKL EDPAIRWQMA LYKDLPNRTD
     DTSDPEKTVE RVLDIANVLF HLEQKSKRVG RRHYCLVEHP QRSKKAVWHK LLSKQRKRAV
     VACFRMAPLY NLPRHRAVNL FLQGYEKSWI ETEEHYFEDK LIEDLAKPGA EPPEEDEGTK
     RVDPLHQLIL LFSRTALTEK CKLEEDFLYM AYADIMAKSC HDEEDDDGEE EVKSFEEKEM
     EKQKLLYQQA RLHDRGAAEM VLQTISASKG ETGPMVAATL KLGIAILNGG NSTVQQKMLD
     YLKEKKDVGF FQSLAGLMQS CSVLDLNAFE RQNKAEGLGM VTEEGSGEKV LQDDEFTCDL
     FRFLQLLCEG HNSDFQNYLR TQTGNNTTVN IIISTVDYLL RVQESISDFY WYYSGKDVID
     EQGQRNFSKA IQVAKQVFNT LTEYIQGPCT GNQQSLAHSR LWDAVVGFLH VFAHMQMKLS
     QDSSQIELLK ELMDLQKDMV VMLLSMLEGN VVNGTIGKQM VDMLVESSNN VEMILKFFDM
     FLKLKDLTSS DTFKEYDPDG KGVISKRDFH KAMESHKHYT QSETEFLLSC AETDENETLD
     YEEFVKRFHE PAKDIGFNVA VLLTNLSEHM PNDTRLQTFL ELAESVLNYF QPFLGRIEIM
     GSAKRIERVY EISESSRTQW EKPQVKESKR QFIFDVVNEG GEKEKMELFV NFCEDTIFEM
     QLAAQISESD LNERSANKEE SEKERPEEQG PRMAFFSILT VKSALFALRY NILTLMRMLS
     LKSLKKQMKK VKKMTVKDMV TAFFSSYWSI FMTLLHFVAS VFRGFFRIVC SLLLGGSLVE
     GAKKIKVAEL LANMPDPTQD EVRGDGEEGE RKPLEAALPS EDLTDLKELT EESDLLSDIF
     GLDLKREGGQ YKLIPHNPNA GLSDLMSNPV PMPEVQEKFQ EQKAKEEEKE EKEETKSEPE
     KAEGEDGEKE EKAKEDKGKQ KLRQLHTHRY GEPEVPESAF WKKIIAYQQK LLNYFARNFY
     NMRMLALFVA FAINFILLFY KVSTSSVVEG KELPTRSSSE NAKVTSLDSS SHRIIAVHYV
     LEESSGYMEP TLRILAILHT VISFFCIIGY YCLKVPLVIF KREKEVARKL EFDGLYITEQ
     PSEDDIKGQW DRLVINTQSF PNNYWDKFVK RKVMDKYGEF YGRDRISELL GMDKAALDFS
     DAREKKKPKK DSSLSAVLNS IDVKYQMWKL GVVFTDNSFL YLAWYMTMSL GHYNNFFFAA
     HFLDIAMGFK TLRTILSSVT HNGKQLVLTV GLLAVVVYLY TVVAFNFFRK FYNKSEDGDT
     PDMKCDDMLT CYMFHMYVGV RAGGGIGDEI EDPAGDEYEI YRIIFDITFF FFVIVILLAI
     IQGLIIDAFG ELRDQQEQVK EDMETKCFIC GIGNDYFDTV PHGFETHTLQ EHNLANYLFF
     LMYLINKDET EHTGQESYVW KMYQERCWEF FPAGDCFRKQ YEDQLN
//
DBGET integrated database retrieval system