ID G1QU58_NOMLE Unreviewed; 525 AA.
AC G1QU58;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 24-JAN-2024, entry version 63.
DE SubName: Full=Receptor like tyrosine kinase {ECO:0000313|Ensembl:ENSNLEP00000004478.2};
GN Name=RYK {ECO:0000313|Ensembl:ENSNLEP00000004478.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000004478.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000004478.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000004478.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR EMBL; ADFV01027977; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01027978; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01027979; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01027980; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1QU58; -.
DR STRING; 61853.ENSNLEP00000004478; -.
DR Ensembl; ENSNLET00000004713.3; ENSNLEP00000004478.2; ENSNLEG00000003710.3.
DR eggNOG; KOG1024; Eukaryota.
DR GeneTree; ENSGT00940000155119; -.
DR HOGENOM; CLU_000288_7_36_1; -.
DR InParanoid; G1QU58; -.
DR OMA; QTWAVAL; -.
DR TreeFam; TF317402; -.
DR Proteomes; UP000001073; Chromosome 8.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:Ensembl.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR CDD; cd05043; PTK_Ryk; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.60.40.2170; Wnt, WIF domain; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR003306; WIF.
DR InterPro; IPR038677; WIF_sf.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR PANTHER; PTHR24416:SF349; TYROSINE-PROTEIN KINASE RYK; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF02019; WIF; 1.
DR PIRSF; PIRSF000615; TyrPK_CSF1-R; 3.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00469; WIF; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS50814; WIF; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Magnesium {ECO:0000256|PIRSR:PIRSR000615-3};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000615-3};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 140..162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..111
FT /note="WIF"
FT /evidence="ECO:0000259|PROSITE:PS50814"
FT DOMAIN 244..521
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 178..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 383
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-1"
FT BINDING 388
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-3"
FT BINDING 401
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-3"
SQ SEQUENCE 525 AA; 59596 MW; 40C4993EAF3C9289 CRC64;
YYVRNDLISH YALSFNLLVP SETNFLHFTW HAKSKVEYKL GFQVDNVLAM DMPQVNISVQ
GEVPRTLSVF RVELSCTGKV DSEVMILMQL NLTVNSSKNF TVLNFKRRKM CYKKLEEVKT
SALDKNTSRT ICNSTTSTRV FYISVGVCCA VIFLVAIILA VLHLHSMKRI ELDDSISASS
SSQGLSQPST QTTQYLRADT PNNATPITSK SYPTLRIEKN DLRSVTLLEA KAKVKDIAIS
RERITLKDVL QEGTFGRIFH GILIDEKDPN KEKQAFVKTV KDQASEIQVT MMLTESCKLR
GLHHRNLLPI THVCIEEGEK PMVILPYMNW GNLKLFLRQC KLVEANNPQV RKICISQQDL
VHMAIQIACG MSYLARREVI HKDLAARNCV IDDTLQVKIT DNALSRDLFP MDYHCLGDNE
NRPVRWMALE SLVNNEFSSA SDVWAFGVTL WELMTLGQTP YVDIDPFEMA AYLKDGYRIA
QPINCPDELF AVMACCWALD PEERPKFQQL VQCLTEFHAA LGAYV
//