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Database: UniProt
Entry: G1QU58_NOMLE
LinkDB: G1QU58_NOMLE
Original site: G1QU58_NOMLE 
ID   G1QU58_NOMLE            Unreviewed;       525 AA.
AC   G1QU58;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   24-JAN-2024, entry version 63.
DE   SubName: Full=Receptor like tyrosine kinase {ECO:0000313|Ensembl:ENSNLEP00000004478.2};
GN   Name=RYK {ECO:0000313|Ensembl:ENSNLEP00000004478.2};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000004478.2, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000004478.2, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000004478.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
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DR   EMBL; ADFV01027977; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01027978; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01027979; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01027980; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; G1QU58; -.
DR   STRING; 61853.ENSNLEP00000004478; -.
DR   Ensembl; ENSNLET00000004713.3; ENSNLEP00000004478.2; ENSNLEG00000003710.3.
DR   eggNOG; KOG1024; Eukaryota.
DR   GeneTree; ENSGT00940000155119; -.
DR   HOGENOM; CLU_000288_7_36_1; -.
DR   InParanoid; G1QU58; -.
DR   OMA; QTWAVAL; -.
DR   TreeFam; TF317402; -.
DR   Proteomes; UP000001073; Chromosome 8.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:Ensembl.
DR   GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR   CDD; cd05043; PTK_Ryk; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   Gene3D; 2.60.40.2170; Wnt, WIF domain; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR003306; WIF.
DR   InterPro; IPR038677; WIF_sf.
DR   PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR   PANTHER; PTHR24416:SF349; TYROSINE-PROTEIN KINASE RYK; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   Pfam; PF02019; WIF; 1.
DR   PIRSF; PIRSF000615; TyrPK_CSF1-R; 3.
DR   PRINTS; PR00109; TYRKINASE.
DR   SMART; SM00469; WIF; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR   PROSITE; PS50814; WIF; 1.
PE   4: Predicted;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR000615-3};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000615-3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        140..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..111
FT                   /note="WIF"
FT                   /evidence="ECO:0000259|PROSITE:PS50814"
FT   DOMAIN          244..521
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          178..209
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        383
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000615-1"
FT   BINDING         388
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000615-3"
FT   BINDING         401
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000615-3"
SQ   SEQUENCE   525 AA;  59596 MW;  40C4993EAF3C9289 CRC64;
     YYVRNDLISH YALSFNLLVP SETNFLHFTW HAKSKVEYKL GFQVDNVLAM DMPQVNISVQ
     GEVPRTLSVF RVELSCTGKV DSEVMILMQL NLTVNSSKNF TVLNFKRRKM CYKKLEEVKT
     SALDKNTSRT ICNSTTSTRV FYISVGVCCA VIFLVAIILA VLHLHSMKRI ELDDSISASS
     SSQGLSQPST QTTQYLRADT PNNATPITSK SYPTLRIEKN DLRSVTLLEA KAKVKDIAIS
     RERITLKDVL QEGTFGRIFH GILIDEKDPN KEKQAFVKTV KDQASEIQVT MMLTESCKLR
     GLHHRNLLPI THVCIEEGEK PMVILPYMNW GNLKLFLRQC KLVEANNPQV RKICISQQDL
     VHMAIQIACG MSYLARREVI HKDLAARNCV IDDTLQVKIT DNALSRDLFP MDYHCLGDNE
     NRPVRWMALE SLVNNEFSSA SDVWAFGVTL WELMTLGQTP YVDIDPFEMA AYLKDGYRIA
     QPINCPDELF AVMACCWALD PEERPKFQQL VQCLTEFHAA LGAYV
//
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