ID G1QV63_NOMLE Unreviewed; 629 AA.
AC G1QV63;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 3.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN Name=OSBP2 {ECO:0000313|Ensembl:ENSNLEP00000004833.3};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000004833.3, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000004833.3, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000004833.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the OSBP family.
CC {ECO:0000256|RuleBase:RU003844}.
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DR EMBL; ADFV01177682; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01177683; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01177684; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01177685; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01177686; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01177687; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01177688; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01177689; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01177690; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01177691; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1QV63; -.
DR Ensembl; ENSNLET00000005083.2; ENSNLEP00000004833.3; ENSNLEG00000003976.2.
DR eggNOG; KOG1737; Eukaryota.
DR GeneTree; ENSGT00940000157987; -.
DR HOGENOM; CLU_007105_5_1_1; -.
DR TreeFam; TF320922; -.
DR Proteomes; UP000001073; Chromosome 7b.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR Gene3D; 2.40.160.120; -; 1.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR PANTHER; PTHR10972:SF194; OXYSTEROL-BINDING PROTEIN 2; 1.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR PROSITE; PS01013; OSBP; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|RuleBase:RU003845};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transport {ECO:0000256|RuleBase:RU003845}.
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 138..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 526..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 109..136
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 527..567
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 629 AA; 71472 MW; D9C86DBB610EB1F1 CRC64;
KNSHYDSGDD DEATTPADKS ELHHTLKNLS LKLDDLSTCN DLIAKHGAAL QRSLTELDGL
KIPSESGEKL KVVNERATLF RITSNAMINA CRDFLELAEI HSRKWQRALQ YEQEQRVHLE
ETIEQLAKQH NSLERAFRSA PGRPANPSKS FIEGSLLTPK GEDSEEDEDT EYFDAMEDST
SFITVITEAK EDRKAEGSTG TSSVDWSSAD SVLDGASLVP KGSSKVKRRV RIPNKPNYSL
NLWSIMKNCI GRELSRIPCR WVNFNEPLSM LQRLTEDLEY HHLLDKAVHC TSSVEQMCLV
AAFSVSSYST TVHRIAKPFN PMLGETFELD RLDDMGLRSL CEQVSHHPPS AAHYVFSKHG
WSLCKFRGKY ISIMPLGAIH LEFQASGNHY VWRKSTSTVH NIIVGKLWID QSGDIEIVNH
KTNDRCQLKF LPYSYFSKEA ARKVTGVVSD SQGKAHYVLS GSWDEQMECS KVVHSSPSSP
SSEGKQKTVY QTLSAKLLWK KYPLPENAEN MYYFSELALT LNEHEEGVAP TDSRLRPDQR
LMEKGRWDEA NTEKQRLEEK QRLSRRRQLE SCGPGSSCSS EEEKEADAYT PLWFEKRLDP
LTGEMACVYK GGYWEAKEKQ DWHMCPNIF
//
