ID G1QWX3_NOMLE Unreviewed; 529 AA.
AC G1QWX3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=methylcrotonoyl-CoA carboxylase {ECO:0000256|ARBA:ARBA00026116};
DE EC=6.4.1.4 {ECO:0000256|ARBA:ARBA00026116};
DE AltName: Full=3-methylcrotonyl-CoA carboxylase 2 {ECO:0000256|ARBA:ARBA00031404};
DE AltName: Full=3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit {ECO:0000256|ARBA:ARBA00031109};
DE AltName: Full=3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta {ECO:0000256|ARBA:ARBA00031237};
GN Name=MCCC2 {ECO:0000313|Ensembl:ENSNLEP00000005444.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000005444.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000005444.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000005444.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate = 3-
CC methyl-(2E)-glutaconyl-CoA + ADP + H(+) + phosphate;
CC Xref=Rhea:RHEA:13589, ChEBI:CHEBI:15378, ChEBI:CHEBI:17544,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57344,
CC ChEBI:CHEBI:57346, ChEBI:CHEBI:456216; EC=6.4.1.4;
CC Evidence={ECO:0000256|ARBA:ARBA00029358};
CC -!- PATHWAY: Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-
CC 3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.
CC {ECO:0000256|ARBA:ARBA00025711}.
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DR EMBL; ADFV01031312; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01031313; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01031314; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01031315; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01031316; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01031317; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01031318; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1QWX3; -.
DR Ensembl; ENSNLET00000005728.3; ENSNLEP00000005444.2; ENSNLEG00000004496.3.
DR eggNOG; KOG0540; Eukaryota.
DR GeneTree; ENSGT00940000155949; -.
DR HOGENOM; CLU_018822_0_1_1; -.
DR TreeFam; TF300446; -.
DR UniPathway; UPA00363; UER00861.
DR Proteomes; UP000001073; Chromosome 18.
DR GO; GO:0016874; F:ligase activity; IEA:InterPro.
DR GO; GO:0006552; P:leucine catabolic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR034733; AcCoA_carboxyl_beta.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR011763; COA_CT_C.
DR InterPro; IPR011762; COA_CT_N.
DR InterPro; IPR045190; MCCB/AccD1-like.
DR PANTHER; PTHR22855; ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED; 1.
DR PANTHER; PTHR22855:SF13; METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL; 1.
DR Pfam; PF01039; Carboxyl_trans; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 2.
DR PROSITE; PS50989; COA_CT_CTER; 1.
DR PROSITE; PS50980; COA_CT_NTER; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..529
FT /note="methylcrotonoyl-CoA carboxylase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011977217"
FT DOMAIN 94..272
FT /note="CoA carboxyltransferase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50980"
FT DOMAIN 275..521
FT /note="CoA carboxyltransferase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50989"
SQ SEQUENCE 529 AA; 57724 MW; EDC8E4E76974E04C CRC64;
MWAALRLALR LCARASPAGL RAYHGDSVAS LGTQPDVGSA LYQENYKQMK ALVNQLHEQV
ERIKLGGGEK ARALHISRGK LLPRERIDNL IDPGVECMII ANDATVKGGT YYPVTVKKQL
RAQEIAMQNR LPCIYLVDSG GAYLPRQADV FADRDHFGRT FYNQAIMSSK NIAQIAVVMG
SCTAGGAYVP AMADENIIVR KQGTIFLAGP PLVKAATGEE VSAEELGGAD LHCRKSGVSD
HYALDDHHAL HLTRKVVRNL NYQKKLDVTI EPSEEPLFPA DELYGIVGAN LKRNFDVREV
IARIVDGSRF TEFKAFYGDT LVTGFARVFG YPVGIVGNNG VLFSESAKKG AHFVQLCCQR
NIPLLFLQNI TGFMVGREYE AEGIAKDGAK MVAAVACAQV PKITLIIGGS YGAGNYGMCG
RAYSPRFLYI WPNARISVMG GEQAANVLAT IAKDQRAREG KQFSSADEAA LKEPIIKKFE
EEGNPYYSSS RVWDDGIIDP ADTRLVLGLS FSAALNAPIE KTDFGIFRM
//
