ID G1QWX4_NOMLE Unreviewed; 919 AA.
AC G1QWX4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Calsyntenin 2 {ECO:0000313|Ensembl:ENSNLEP00000005445.2};
GN Name=CLSTN2 {ECO:0000313|Ensembl:ENSNLEP00000005445.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000005445.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000005445.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000005445.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004614}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004614}. Postsynaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00035006}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00035006}.
CC -!- SIMILARITY: Belongs to the calsyntenin family.
CC {ECO:0000256|ARBA:ARBA00035015}.
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DR EMBL; ADFV01028367; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01028368; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01028369; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01028370; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01028371; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01028372; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01028373; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01028374; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01028375; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01028376; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1QWX4; -.
DR STRING; 61853.ENSNLEP00000005445; -.
DR Ensembl; ENSNLET00000005729.3; ENSNLEP00000005445.2; ENSNLEG00000004476.3.
DR eggNOG; KOG1834; Eukaryota.
DR GeneTree; ENSGT00950000183086; -.
DR HOGENOM; CLU_008904_0_0_1; -.
DR InParanoid; G1QWX4; -.
DR OMA; HMVIQPQ; -.
DR TreeFam; TF315946; -.
DR Proteomes; UP000001073; Chromosome 8.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098839; C:postsynaptic density membrane; IEA:Ensembl.
DR GO; GO:0001540; F:amyloid-beta binding; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0019894; F:kinesin binding; IEA:InterPro.
DR GO; GO:0042988; F:X11-like protein binding; IEA:InterPro.
DR GO; GO:0008306; P:associative learning; IEA:Ensembl.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:1904862; P:inhibitory synapse assembly; IEA:Ensembl.
DR GO; GO:0051965; P:positive regulation of synapse assembly; IEA:Ensembl.
DR GO; GO:0050806; P:positive regulation of synaptic transmission; IEA:Ensembl.
DR CDD; cd11304; Cadherin_repeat; 2.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 2.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR026914; Calsyntenin.
DR InterPro; IPR045588; CLSTN_C.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR PANTHER; PTHR14139; CALSYNTENIN; 1.
DR PANTHER; PTHR14139:SF3; CALSYNTENIN-2; 1.
DR Pfam; PF00028; Cadherin; 1.
DR Pfam; PF19699; CLSTN_C; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 2.
DR SUPFAM; SSF49313; Cadherin-like; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS50268; CADHERIN_2; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|PROSITE-ProRule:PRU00043};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 791..816
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 7..123
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 124..243
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 850..919
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 862..892
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 919 AA; 103367 MW; 713E3E579C3D70EA CRC64;
NKHKPWIETS YHGVITENND TVILDPPLVA LDKDAPVPFA GEICAFKIHG QELPFEAVVL
NKTSGEGRLR AKSPIDCELQ KEYTFIIQAY DCGAGPHETA WKKSHKAVVH IQVKDVNEFA
PTFKEPAYKA VVTEGKIYDS ILQVEAIDED CSPQYSQICN YEIVTTDVPF AIDRNGNIRN
TEKLSYDKQH QYEILVTAYD CGQKPAAQDT LVQVDVKPVC KPGWQDWTKR IEYQPGSGSM
PLFPSIHLET CDGAVSSLQI VAELQTNYIG KGCDRETYSE KSLQKLCGAS SGIIDLLPSP
SAATNWTAGL LVDSSEMIFK FDGRQGAKIP DGIVPKNLTD QFTITMWMKH GPSPGVRAEK
ETILCNSDKT EMNRHHYALY VHNCRLVFLL RKDFDQADTF RPAEFHWKLD QICDKEWHYY
VINVEFPVVT LYMDGATYEP YLVTNDWPIH PSHIAMQLTV GACWQGGEVT KPRFAQFFHG
SLASLTIRPG KMESQKVISC LQACKEGLDI NSLESLGQGI KYHFNPSQSI LVMEGDDIGN
INRALQKISY INSRQFPTAG VRRLKVSSKV QCFGEDVCIS IPEVDAYVMV LQAIEPRITL
RGTDHFWRPA AQFESARGVT LFPDIKIVST FAKTEAPGDV KTTAPKSEVL EEMLHNLDFC
DILVIGGDLD PRQECLELNH SELHQRHLDA TNSTAGYSIY GVGSMSRYEQ VLHHIRYRNW
RPASLEARHF RIKCSELNGR YTSNEFNLEV SVLHEDRVSD KEHVNHLIVQ PPFLQSVHHP
ESRSSIQHSS VVPSIATVVI IISVCMLVFV VAMGVYRVRI AHQHFIQETE AAKESEMDWD
DSALTITVNP MEKHEGPGHG EDETEGEEEE EAEEEMSSSS GSDDSEEEEE EEEGMGRGRH
GQNGARQAQL EWDDSTLPY
//
