ID G1QXY9_NOMLE Unreviewed; 4624 AA.
AC G1QXY9;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 3.
DT 24-JAN-2024, entry version 84.
DE RecName: Full=Low-density lipoprotein receptor {ECO:0000256|ARBA:ARBA00039475};
GN Name=LRP2 {ECO:0000313|Ensembl:ENSNLEP00000005810.3};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000005810.3, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000005810.3, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000005810.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- FUNCTION: Binds LDL, the major cholesterol-carrying lipoprotein of
CC plasma, and transports it into cells by endocytosis. In order to be
CC internalized, the receptor-ligand complexes must first cluster into
CC clathrin-coated pits. {ECO:0000256|ARBA:ARBA00037220}.
CC -!- SUBCELLULAR LOCATION: Late endosome {ECO:0000256|ARBA:ARBA00004603}.
CC Membrane, clathrin-coated pit {ECO:0000256|ARBA:ARBA00004600}.
CC -!- SIMILARITY: Belongs to the LDLR family.
CC {ECO:0000256|ARBA:ARBA00009939}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; ADFV01058400; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01058401; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01058402; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01058403; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01058404; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01058405; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01058406; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01058407; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01058408; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01058409; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 61853.ENSNLEP00000005810; -.
DR Ensembl; ENSNLET00000006115.2; ENSNLEP00000005810.3; ENSNLEG00000004701.3.
DR eggNOG; KOG1215; Eukaryota.
DR GeneTree; ENSGT00940000157232; -.
DR HOGENOM; CLU_000085_1_1_1; -.
DR InParanoid; G1QXY9; -.
DR TreeFam; TF315253; -.
DR Proteomes; UP000001073; Chromosome 22a.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0030424; C:axon; IEA:Ensembl.
DR GO; GO:0031526; C:brush border membrane; IEA:Ensembl.
DR GO; GO:0005905; C:clathrin-coated pit; IEA:Ensembl.
DR GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR GO; GO:0030139; C:endocytic vesicle; IEA:Ensembl.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0005768; C:endosome; IEA:Ensembl.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR GO; GO:0051087; F:protein-folding chaperone binding; IEA:Ensembl.
DR GO; GO:0035904; P:aorta development; IEA:Ensembl.
DR GO; GO:0060982; P:coronary artery morphogenesis; IEA:Ensembl.
DR GO; GO:0034311; P:diol metabolic process; IEA:Ensembl.
DR GO; GO:1904447; P:folate import across plasma membrane; IEA:Ensembl.
DR GO; GO:0030900; P:forebrain development; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0008584; P:male gonad development; IEA:Ensembl.
DR GO; GO:0030001; P:metal ion transport; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
DR GO; GO:0140058; P:neuron projection arborization; IEA:Ensembl.
DR GO; GO:0003148; P:outflow tract septum morphogenesis; IEA:Ensembl.
DR GO; GO:0043491; P:phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0070447; P:positive regulation of oligodendrocyte progenitor proliferation; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:Ensembl.
DR GO; GO:0061156; P:pulmonary artery morphogenesis; IEA:Ensembl.
DR GO; GO:0006898; P:receptor-mediated endocytosis; IEA:Ensembl.
DR GO; GO:0044321; P:response to leptin; IEA:Ensembl.
DR GO; GO:0003139; P:secondary heart field specification; IEA:Ensembl.
DR GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR GO; GO:0060068; P:vagina development; IEA:Ensembl.
DR GO; GO:0003223; P:ventricular compact myocardium morphogenesis; IEA:Ensembl.
DR GO; GO:0003281; P:ventricular septum development; IEA:Ensembl.
DR GO; GO:0042359; P:vitamin D metabolic process; IEA:Ensembl.
DR CDD; cd00054; EGF_CA; 3.
DR CDD; cd00112; LDLa; 34.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 36.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 8.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR019825; Lectin_legB_Mn/Ca_BS.
DR PANTHER; PTHR22722:SF11; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2; 1.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF14670; FXa_inhibition; 2.
DR Pfam; PF00057; Ldl_recept_a; 34.
DR Pfam; PF00058; Ldl_recept_b; 14.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 25.
DR SMART; SM00179; EGF_CA; 10.
DR SMART; SM00192; LDLa; 36.
DR SMART; SM00135; LY; 37.
DR SUPFAM; SSF57196; EGF/Laminin; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 36.
DR SUPFAM; SSF63825; YWTD domain; 8.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 6.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01187; EGF_CA; 3.
DR PROSITE; PS01209; LDLRA_1; 19.
DR PROSITE; PS50068; LDLRA_2; 36.
DR PROSITE; PS51120; LDLRB; 23.
DR PROSITE; PS00307; LECTIN_LEGUME_BETA; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW LDL {ECO:0000256|ARBA:ARBA00022710};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 4407..4429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 422..464
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 465..507
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 508..554
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 555..599
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 736..778
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 779..820
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 821..864
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 865..908
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1461..1503
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1504..1546
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1549..1592
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1866..1913
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1914..1955
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2185..2228
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2229..2272
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2502..2545
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2546..2587
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3222..3264
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3316..3359
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3360..3402
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 4137..4179
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 4180..4223
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 4225..4266
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 4360..4394
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 4521..4543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4570..4624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4582..4599
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 14..26
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 21..39
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 33..48
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 94..106
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 101..119
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 113..128
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 138..156
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 150..165
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 169..181
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 176..194
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 188..203
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 208..220
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 215..233
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 227..242
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1009..1021
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1016..1034
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1028..1043
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1050..1062
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1057..1075
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1069..1084
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1092..1104
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1099..1117
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1111..1126
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1132..1144
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1139..1157
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1151..1166
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1190..1205
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1254..1266
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1261..1279
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1273..1288
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2683..2695
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2690..2708
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2724..2736
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2731..2749
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2743..2758
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2771..2789
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2847..2859
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2854..2872
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2889..2901
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2896..2914
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2976..2988
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2983..3001
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2995..3010
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3015..3027
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3022..3040
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3058..3070
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3065..3083
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3077..3092
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3536..3548
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3543..3561
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3577..3589
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3584..3602
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3618..3630
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3625..3643
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3682..3697
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3710..3728
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3722..3737
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3742..3754
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3749..3767
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3761..3776
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3781..3793
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3788..3806
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3800..3815
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3825..3837
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3832..3850
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3874..3892
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3911..3923
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3918..3936
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3930..3945
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 4384..4393
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4624 AA; 518713 MW; 2C4154314BBCC991 CRC64;
LDNFLKFLSV IAECDSEHFR CGSGHCIPAD WRCDGTKDCS DDADEIGCAV VTCQQGYFRC
QSEGQCIPNS WVCDQDQDCD DGSDERQDCS QNTCSSHQIT CSNGQCIPSE YRCDHVRDCP
DGADENDCQY PTCEQLTCDN GACYNTSQKC DWKVDCRDSS DEVNCTEICL HNEFSCGSGE
CIPRAYVCDH DNDCQDGSDE HACNYPTCGG HQFTCPSGRC IYQNWVCDGE DDCKDNGDED
GCESSPHDVH KCSPREWSCP ESGRCISIYK VCDGILDCPG REDENSTTTG KYCSTTLCSA
LNCQYQCHET PYGGACFCPP GYIINHNDSR TCVEFDDCQI WGICDQKCES RPGHHLCHCE
EGYILERGQY CKANNSFGEA SIIFSNGRDL LIGDIHGRSF RILVESQNRG VAVGVAFHYH
LQRVFWTDTV QNKVFSVDIN GLNIQEVLNV SVETPENLAV DWVNNKIYLV ETKVNRIDMV
NLDGSYRVTL ITENLGHPRG IAVDPTVGYL FFSDWESLSG EPKLERAFMD GSNRKDLVKT
KLGWPAGVTL DTISKRVYWV DSRFDYIETV TYDGIQRKTV VHGGSLIPHP FGISLFEGQV
FFTDWTKMAV LKANKFTETN PQVYYQASLR PYGVTVYHSL RQPYATNPCK DNNGGCEQVC
VLSHRTDNDG LGFRCKCTFG FQLDTDERPV QNFLIFSSQV AIRGIPFTLS TQEDVMVPVS
GNPSFFVGID FDAQDSSIFF SDMSKHMIFK QKIDGTGREI LAANRVENVE SLAFDWISKN
LYWTDSHYKS ISVMRLADKT RRTVVQYLNN PRSVVVHPFA GYLFFTDWFR PAKIMRAWSD
GSHLLPIVNT TLGWPNGLAI DWAASRLYWV DAYFDKIEHS TFDGLDRRRL GHIEQMTHPF
GLAIFGEYLF FTDWRLGAII RVRKADGGEM TVIRSGIAYI LHLKSYDVNI QTGSNACNQP
THPNGDCSHF CFPVPNFQRV CGCPYGMKLA SNHLTCEGDP TNEPPTEQCG LFSFPCKNGR
CVPNYYRCDG VDDCHDNSDE QLCGTLNNTC SSSAFTCGHG ECIPAHWRCD KRNDCVDGSD
EHNCPTHAPA SCLDTQYTCD NHQCISKNWV CDTDNDCGDG SDEKNCNSTE TCQPSQFNCP
NHRCIDLSFV CDGDKDCVDG SDEVGCVLNC TASQFKCASG DKCISVTNRC DGVFDCSDNS
DEAGCPTRPP GMCHSDEFQC QEDGICIPNF WECDGHPDCL YGSDEHNACV PKTCPSSYFH
CDNGNCIHRA WLCDRDNDCG DMSDEKDCPT QPFRCPSWQW QCLGHNICVN LSVVCDGIFD
CPNGTDESPL CNGNSCSDFN GGCTHECVQE PFGAKCLCPL GFLLANDSKT CEDIDECDIP
GSCSQHCYNM RGSFRCSCDT GYMLESDGRT CKVTASESLL LLVASQNKII ADSVTSQVHN
IYSLVENGSY IVAVDFDSIS GRIFWSDATQ GKTWSAFQNG TDRRVVFDSS IILTETIAID
WVGRNLYWTD YALETIEVSK IDGSHRTVLI SKNLTNPRGL ALDPRMNEHL LFWSDWGHHP
RIERASMDGS MRTVIVQDKI FWPCGLTVDY PNRLLYFMDS YLDYMDFCDY NGHHRRQVIA
SDLIIRHPYA LTLFEDSVYW TDRATRRVMR ANKWHGGNQS VVMYNIQWPL GIVAVHPSKQ
PNSVNPCAFS RCSHLCLLSS QGPHFYSCVC PSGWSLSPDL LNCLRDDQPF LITVRQHIIF
GISLNPDVRS NDAMVPIAGI QNGLDVEFDD AEQYIYWVEN PGEIHRVKTD GTNRTVFASI
SMVGPSMNLA LDWISRNLYS TNPRTQSIEV LTLHGDIRYR KTLIANDGTA LGVGFPIGIT
VDPSRGKLYW SDQGTDSGVP AKIASANMDG TSVKTLFTGN LEHLECVTLD IEEQKLYWAV
TGRGVIERGN VDGTDRMILV HQLSHPWGIA VYDSFLYYTD EQYEVIERVD KATGANKIVL
RDNVPNLRGL QVYHRRNAAE SSNGCSNNMN ACQQICLPVP GGLFSCACAT GFKLNPDNRS
CSPYNSFIVV SMLSAIRGFS LELSDHSETM VPVAGQGRNA LHVDVDVSSG FIYWCDFSSS
VASDNAIRRI KPDGSSLTNI VTHGIGENGV RGIAVDWVAG NLYFTNAFVS ETLIEVLRIN
TTYRRVLLKV TVDMPRHIVV DPKNRYLFWA DYGQRPKIER SFLDCTNRTV LVSEGIVTPR
GLAVDRSDGY VYWVDDSLDI IARIRINGEN SEVIRYGSRY PTPYGITVFE NSIIWVDRNL
KKIFQASKEP ENTDPPTVIR DNINWLRDVT IFDKQVQRQS PAEVNNNPCL ENNGGCSHLC
LALPGLHTPK CDCAFGTLQS DGKNCAISTE NFLIFALSNS LRSLHLDPEN HSPPFQTINV
ERTVMSLDYD SVSDRIYFTQ NLASGVGQIS YVSLSSGIHT PTVIASGIGT ADGIAFDWIT
RRIYYSDYLN QTINSMAEDG SNRTVIARVP KPRAIVLDPC QGYLYWADWD THAKIERATL
GGNFRVPIVN SSLVMPSGLT LDYEEDLLYW VDASLQRIER STRTGMDREV IVNAAVHAFG
LTLYGQYIYW TDLYTQRIYR ANKYDGSGQI AMTTNLLSQP RGINTVVKNQ KQQCNNPCEQ
FNGGCSHICA PGPNGAECQC PHEGNWYLAN NRKHCIVDNG ERCGASSFTC SNGRCISEEW
KCDNDNDCGD GSDEMESVCA LHTCLPTAFT CANGRCVQYS YRCDYYNDCG DGSDEAGCLF
RDCNATTEFM CNNRRCIPRE FVCNGVDNCH DNNTSDEKNC PDRTCQSGYT KCHNSNICIP
RVYLCDGDND CGDNSDENPT YCTTHTCSSS EFQCTSGRCI PQHWYCDQET DCFDASDEPA
SCGHSERTCL ADEFKCDGGR CIPSEWICDG DNDCGDMSDE DERHQCQNQN CSDSEFLCVN
DRPPDRRCIP QSWVCDGDVD CTDGYDENQN CTRRTCSENE FTCGYGLCIP KIFRCDRHND
CGDYSDERGC LYQTCQQNQF TCQNGRCISK TFVCDEDNDC GDGSDELMHL CHTPEPTCPP
HEFKCDNGRC IEMMKLCNHL DDCLDNSDEK GCGINECHDP SISGCDHNCT DTLTSFYCSC
RPGYKLMSDK RTCVDIDECT EMPFVCSQKC ENVIGSYICK CAPGYLREPD GKTCRQNSNI
EPYLIFSNRY YLRNLTIDGY FYSLILEGLG NVVALDFDRV EKRLYWIDTQ RQVIERMFLN
KTNKETVINH RLPAAESLAV DWVSRKLYWL DARLDGLFVS DLNGGHRRML AQHCVDANNT
FCFDNPRGLA LHPQYGYIYW ADWGHRAYIG RVGMDGTNKS VIISTKLEWP NGITIDYTND
LLYWADAHLG YIEYSDLEGH HRHTVYDGAL PHPFAITIFE DTIYWTDWNT RTVEKGNKYD
GSNRQTLVNT THRPFDIHVY HPYRQPIVSN PCGTNNGGCS HLCLIKPGGK GFTCECPDDF
RTLQLSGSTY CMPMCSSTQF LCANNEKCIP IWWKCDGQKD CSDGSDELAL CPQRFCRLGQ
FQCNDGNCTS PQTLCNAHQN CPDGSDEDRL LCENHHCDSN EWQCANKRCI PESWQCDTFN
DCEDNSDEDS SHCASRTCRP GQFRCANGRC IPQAWKCDVD NDCGDHSDEP IEECMSSAHL
CDNFTEFSCK TNYRCIPKWA VCNGVDDCRD NSDEQGCEER TCHPVGDFRC KNHHCIPLRW
QCDGQNDCGD NSDEENCAPR ECTESEFRCV NQQCIPSRWI CDHYNDCGDN SDERDCEMRT
CHPEYFQCTS GHCVPSELKC DGTADCLDAS DEADCPTRFP DGAYCQATMF ECKNHVCIPP
YWKCDGDDDC GDGSDEELHL CLNVPCNSPN RFRCDNNRCI YGHEVCNGVD DCGDGTDETE
EHCRKPTPKP CTEYEYKCGN GHCVPHDNVC DDADDCGDWS DELGCNKGKE RTCAENICEQ
NCTQLNEGGF ICSCTAGFET NVFDRTSCLD INECEQFGTC PQHCRNTKGS YECVCADGFT
SMSDRPGKRC AAEGNSPLLL LPDNVRIRKY NLSSERFSEY LQDEEYIQAV DYDWDPEGIG
LSVVYYTVRA EGSRFGAIKR AYIPNFESGR NNLVQEVDLK LKYVMQPDGI AVDWVGRHIY
WSDVKNKRIE VAKLDGRYRK WLISTDLDQP AAIAVNPKLG LMFWTDWGKE PKIESAWMNG
EDRNILVFED LGWPTGLSID YLNNDRLYWS DFKEDVIETI KCDGTDRRVI AKEAMNPYSL
DIFEDQLYWI SKEKGEVWKQ NKFGQGKKEK TLVVNPWLTQ VRIFHQLRYN KSVPNLCKQI
CSHLCLLRPG GYSCACPQGS TFIEGSTTEC DAAIELPINL PPPCRCMHGG NCYFDETDLP
KCKCPSGYTG KYCEMAFSKG ISPGTTAVAV LLTILLIVVI GALAIAGFFH YRRTGSLLPA
LPKLPSLSSL VKPSENGNGV TFRSGADLNM DIGVSGFGPE TAIDRSMAMD SQFISEIGEI
FLLPLICPQV TVSGNVDNKN YGSPINPSEI VPETNPTSPA ADGTQVTKWN LFKRKAKQTT
NFENPIYAQM ENEQKESVAA TPPPSPSLPA KPKPPSRRDP APTYSATEDT FKDTANLVKE
DSEV
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