ID G1QZG3_NOMLE Unreviewed; 1161 AA.
AC G1QZG3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 3.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Transcription termination factor 2 {ECO:0000313|Ensembl:ENSNLEP00000006334.3};
GN Name=TTF2 {ECO:0000313|Ensembl:ENSNLEP00000006334.3};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000006334.3, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000006334.3, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000006334.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01041680; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01041681; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01041682; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01041683; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003268094.1; XM_003268046.3.
DR RefSeq; XP_012356038.1; XM_012500584.1.
DR AlphaFoldDB; G1QZG3; -.
DR STRING; 61853.ENSNLEP00000006334; -.
DR Ensembl; ENSNLET00000006658.3; ENSNLEP00000006334.3; ENSNLEG00000005209.3.
DR GeneID; 100600950; -.
DR KEGG; nle:100600950; -.
DR CTD; 8458; -.
DR eggNOG; KOG4439; Eukaryota.
DR GeneTree; ENSGT00940000162718; -.
DR HOGENOM; CLU_000315_2_2_1; -.
DR InParanoid; G1QZG3; -.
DR OMA; IVSQWTN; -.
DR OrthoDB; 200191at2759; -.
DR TreeFam; TF316297; -.
DR Proteomes; UP000001073; Chromosome 12.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd18072; DEXHc_TTF2; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR InterPro; IPR010666; Znf_GRF.
DR PANTHER; PTHR45626:SF54; TRANSCRIPTION TERMINATION FACTOR 2; 1.
DR PANTHER; PTHR45626; TRANSCRIPTION TERMINATION FACTOR 2-RELATED; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR Pfam; PF06839; zf-GRF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51999; ZF_GRF; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU01343}.
FT DOMAIN 6..46
FT /note="GRF-type"
FT /evidence="ECO:0000259|PROSITE:PS51999"
FT DOMAIN 582..785
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 994..1156
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 146..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 460..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 869..889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..219
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..277
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..396
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..485
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1161 AA; 129179 MW; 8E5EC2A5416BC25B CRC64;
MEVVRCSEHG TLCFLKTGVR DGPNKGKSFY VCRADTCSFV RATDIPVSHC LLHEDFVVEL
QGLLLPQDKK EYRLFFRCIR SKAEGKRWCG SIPWQDPDSK EHSVPNKSQH ASETFHHFSN
RLRNPFKVLD KNQEPVLWKQ LIKGEGEEKT ADKKQREKGD QLFDQKKEQK PESMEKDLSS
GLVPKKKQSV VQEKKQEERA EIQCEAETGG THKRDFSEIK SQQCQGNELT RPSASSQKTS
SGKSQNVQRG SEPLREKDTQ LLPQNVHSHN SVSKPQKGGP LNKEYTNWEA KETKAKDGPS
TQATQKSLPR GHFQERPETH RVPAPGGPAA QAAPAAPGLS LGEGRESATS SDDEEEDDVV
FVSSKPGSPL LFDSTLDSQT KENQFPDQSV QRKVSPASGV SKKVEPSDPA AQRVYLTTQL
KQKKSTLASV NIQALPDKGQ KLIKQIQELE EALSGLALSP EQGTNEKSNS QVPQQSHFTK
TTTGPPHLVP PQPLPGHGTQ PVGSLELKSA CQVTAGGSSQ CYRGHTNQDH VHAVWKITSE
AIDQLHRSLE SCPGETAVAE DPAGLKVPLL LHQKQALAWL LWRESQKPQG GILADDMGLG
KTLTMIALIL TQKNQEKKKE KEKSTALTWL SKDDSSDFTS HGTLIICPAS LIHHWKNEVE
KRVNSNKLRV YLYHGPNRDS RARVLSTYDI VITTYSLVAK EIPTNKQEAE IPGANLSVEG
TSTPLLRIAW ARIILDEAHN VKNPRVQTSI AVCKLQACAR WAVTGTPIQN NLLDMYSLLK
FLRCSPFDEF NLWRSQVDNG SKKGGERLSI LTKSLLLRRT KDQLDSTGRP LVILPQRKFQ
LHHLKLSEDE ETVYNVSFAR SRSALQSYLK RHESRGNQSG RSPNNPFSRV ALEFGSEEPR
HSEAADSPRS STVHILSQLL RLRQCCCHLS LLKSALDPME LKGEGLILSL EEQLSALTLS
ELRDSEPSST VSLNGTFFKM ELFEDTREST KISSLLAELE AIQRNSASQK SVIVSQWTNM
LKVVALHLKK HGLTYATIDG SVNPKQRMDL VEAFNHSRGP QVMLISLLAG GVGLNLTGGN
HLFLLDMHWN PSLEDQACDR IYRVGQQKDV VIHRFVCEGT VEEKILQLQE KKKDLAKQVL
SGSGESVTKL TLADLRVLFG I
//
