ID G1R0A5_NOMLE Unreviewed; 1705 AA.
AC G1R0A5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 24-JAN-2024, entry version 69.
DE SubName: Full=Sodium voltage-gated channel alpha subunit 11 {ECO:0000313|Ensembl:ENSNLEP00000006626.2};
GN Name=SCN11A {ECO:0000313|Ensembl:ENSNLEP00000006626.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000006626.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000006626.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000006626.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR EMBL; ADFV01172347; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01172348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01172349; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01172350; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 61853.ENSNLEP00000006626; -.
DR Ensembl; ENSNLET00000006958.2; ENSNLEP00000006626.2; ENSNLEG00000026898.2.
DR eggNOG; KOG2301; Eukaryota.
DR GeneTree; ENSGT00940000161553; -.
DR HOGENOM; CLU_000540_5_0_1; -.
DR InParanoid; G1R0A5; -.
DR OMA; VEIDMFP; -.
DR Proteomes; UP000001073; Chromosome 4.
DR GO; GO:0044295; C:axonal growth cone; IEA:Ensembl.
DR GO; GO:0044299; C:C-fiber; IEA:Ensembl.
DR GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:InterPro.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR GO; GO:0099610; P:action potential initiation; IEA:Ensembl.
DR GO; GO:0002526; P:acute inflammatory response; IEA:Ensembl.
DR GO; GO:0060840; P:artery development; IEA:Ensembl.
DR GO; GO:0007409; P:axonogenesis; IEA:Ensembl.
DR GO; GO:0061367; P:behavioral response to acetic acid induced pain; IEA:Ensembl.
DR GO; GO:0061368; P:behavioral response to formalin induced pain; IEA:Ensembl.
DR GO; GO:1990408; P:calcitonin gene-related peptide receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0070588; P:calcium ion transmembrane transport; IEA:Ensembl.
DR GO; GO:0048870; P:cell motility; IEA:Ensembl.
DR GO; GO:0070417; P:cellular response to cold; IEA:Ensembl.
DR GO; GO:0002544; P:chronic inflammatory response; IEA:Ensembl.
DR GO; GO:0007623; P:circadian rhythm; IEA:Ensembl.
DR GO; GO:0050966; P:detection of mechanical stimulus involved in sensory perception of pain; IEA:Ensembl.
DR GO; GO:0050965; P:detection of temperature stimulus involved in sensory perception of pain; IEA:Ensembl.
DR GO; GO:0043303; P:mast cell degranulation; IEA:Ensembl.
DR GO; GO:0086010; P:membrane depolarization during action potential; IEA:Ensembl.
DR GO; GO:0060073; P:micturition; IEA:Ensembl.
DR GO; GO:0019228; P:neuronal action potential; IEA:Ensembl.
DR GO; GO:0010737; P:protein kinase A signaling; IEA:Ensembl.
DR GO; GO:0060004; P:reflex; IEA:Ensembl.
DR GO; GO:0010996; P:response to auditory stimulus; IEA:Ensembl.
DR GO; GO:0009408; P:response to heat; IEA:Ensembl.
DR GO; GO:0009644; P:response to high light intensity; IEA:Ensembl.
DR GO; GO:0071731; P:response to nitric oxide; IEA:Ensembl.
DR GO; GO:0034695; P:response to prostaglandin E; IEA:Ensembl.
DR GO; GO:0009636; P:response to toxic substance; IEA:Ensembl.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR GO; GO:0160025; P:sensory perception of itch; IEA:Ensembl.
DR GO; GO:0060538; P:skeletal muscle organ development; IEA:Ensembl.
DR GO; GO:1990770; P:small intestine smooth muscle contraction; IEA:Ensembl.
DR GO; GO:0040040; P:thermosensory behavior; IEA:Ensembl.
DR GO; GO:0001966; P:thigmotaxis; IEA:Ensembl.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF210; SODIUM CHANNEL PROTEIN TYPE 11 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 130..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 161..180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 200..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 253..276
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 377..399
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 578..596
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 608..629
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 700..724
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 787..812
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1058..1076
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1119..1141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1167..1193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1286..1309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1359..1382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1402..1420
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1432..1450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1487..1515
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 128..409
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 577..820
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 828..1052
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 1056..1318
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1367..1558
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 472..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 407..434
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1705 AA; 194998 MW; EC02F4E790E7A1D4 CRC64;
MDDRCYPVIF PDERNFRPFT SDSLAAIEKR IAIQKEKKKS KDQTGEVPQP QPQLDLKASR
KLPKLYGDIP RELIGKPLED LDPFYRNHKT FMVLNKKRTI YRFSAKRALF IFGPFNSIRS
LAIRVSVHSL FSMFIIGTVI INCVFMATGP AKNSNSNNTD IAECVFTGIY IFEALIKILA
RGFILDEFSF LRDPWNWLDS IVIGIAIVSY IPGITIQVSS LRTFRVFRAL KAISVVSRLK
VIVGALLRSV KKLVNVIILT FFCLSIFALV GQQLFMGSLD LKCISRDCKI ISNLEAYDHC
LEKKENSTEF KMCGTWMGNS ACSIQYECRH TKMNPDYNYT NFDNFGWSFL AMFRLMTQDS
WEKLYQQTLR TTGLYSVFFF IVVIFLGSFY LINLTLAVVT MAYEEQNKNV AAEIEAKEKM
FQEAQQLLKE EKEALVAMGI DRSSLTSLET SYFTPKKRKL FGNKKRKSFF LRESGKDQPP
GSDSDEDSQK KPQLLEQTKR LSQNLSLDHF DEHGDPLQRQ RALSAVSILT ITMKEQEKSQ
EPCLPCGENL ASKYLVWNCC PQWLCIKKVL RTVMTDPFTE LAITICIIIN TVFLAMEHHK
MEESFEKMLN IGNSVFTGIF MAEMCLKIIA LDPYHYFRRG WNIFDSIVAL LSFADVISSK
FEKGSWPFLR SFRVLRVFKL AKSWPTLNTL IKIIGNSVGA LGSLTVVLVI VIFIFSVVGM
QLFGHSFNSR KSKKLCGLTG PTVSCLRHWH MGDFWHSFLV VFRILCGEWI ENMWECMQEA
NGSSSSLCVI VFILITVIGK LVVLNLFIAL LLNSFSNEER NGNLEGEARK TKVQLALDRF
RRGFCFVRHI LEHFCHKWCR KQNLPQQKEV TGGCAAQSKD IIHLVMEMKR SSETQEELGI
LTSVPKTLGV RHDWTWLAPL AEEEDDVEFS GEDNAQRITQ PEAEQQAYEL HQENKKPTSQ
RVQSVEIDMF SEDEPHLTIQ DPRKKSDVTS ILSECSTIDL QDGFGWLPEM VPKKEPERCL
PKGFGCCFPC CSLDKRKPPW VIWWNLRKTC YQIVKHSWFE SFIIFVILLS SGALIFEDVH
LEKQPKIQEL INCTDIIFTY IFIGEMVLKW VAFGFGKYFT SAWCCLDFII VIISVTTLIN
LKELKSFRTL RALRPLRALS QFEGMKVVVN ALIGAIPAIL NVLLVCLIFW LIFCILGVHF
FSGKFGKCIN GTDSVINYTI ITNKSQCESG NFSWINQKVN FDNVGNAYLA LLQVATFKGW
MDIIYAAVDS REKEQQPEFE SNSFGYIYFV VFIIFGSFFT LNLFIGVIID NFNQQQKKLG
GQDIFMTEEQ KKYYNAMKKL GSKKPQKPIP RPLNKCQGLV FDVVTSQIFD IVIISLIILN
MISMMAESNN QPEAMKSILD HLNLVFVVIF TLECLIKIFA LRQYYFTNGW NLFDCVVVLL
SIVSTMISTL EKQEYIPFPP TLFRIVRLAR IGRILRLVRA ARGIRTLLFA LMMSLPSLFN
IGLLLFLIMF IYAILGMNWF SKVNPESGID DIFNFKTFAS SMLCLFQIST SAGWDSLLSL
SDFADALPEP LRVAKPNKYQ FLVMDLPMVS GDRLHCMDIL FAFTARVLGG SDGLDSMKTM
MEEKFMEANP LKKLYEPIVT TTKRKEEERG AAIIQKAFRK YMMKVTKGDQ GDQNDLENRP
HSPLQTLCNG DLSSFGVAKG KVHCD
//