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Database: UniProt
Entry: G1R0A5_NOMLE
LinkDB: G1R0A5_NOMLE
Original site: G1R0A5_NOMLE 
ID   G1R0A5_NOMLE            Unreviewed;      1705 AA.
AC   G1R0A5;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   24-JAN-2024, entry version 69.
DE   SubName: Full=Sodium voltage-gated channel alpha subunit 11 {ECO:0000313|Ensembl:ENSNLEP00000006626.2};
GN   Name=SCN11A {ECO:0000313|Ensembl:ENSNLEP00000006626.2};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000006626.2, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000006626.2, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000006626.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
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DR   EMBL; ADFV01172347; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01172348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01172349; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01172350; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 61853.ENSNLEP00000006626; -.
DR   Ensembl; ENSNLET00000006958.2; ENSNLEP00000006626.2; ENSNLEG00000026898.2.
DR   eggNOG; KOG2301; Eukaryota.
DR   GeneTree; ENSGT00940000161553; -.
DR   HOGENOM; CLU_000540_5_0_1; -.
DR   InParanoid; G1R0A5; -.
DR   OMA; VEIDMFP; -.
DR   Proteomes; UP000001073; Chromosome 4.
DR   GO; GO:0044295; C:axonal growth cone; IEA:Ensembl.
DR   GO; GO:0044299; C:C-fiber; IEA:Ensembl.
DR   GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR   GO; GO:0099610; P:action potential initiation; IEA:Ensembl.
DR   GO; GO:0002526; P:acute inflammatory response; IEA:Ensembl.
DR   GO; GO:0060840; P:artery development; IEA:Ensembl.
DR   GO; GO:0007409; P:axonogenesis; IEA:Ensembl.
DR   GO; GO:0061367; P:behavioral response to acetic acid induced pain; IEA:Ensembl.
DR   GO; GO:0061368; P:behavioral response to formalin induced pain; IEA:Ensembl.
DR   GO; GO:1990408; P:calcitonin gene-related peptide receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0070588; P:calcium ion transmembrane transport; IEA:Ensembl.
DR   GO; GO:0048870; P:cell motility; IEA:Ensembl.
DR   GO; GO:0070417; P:cellular response to cold; IEA:Ensembl.
DR   GO; GO:0002544; P:chronic inflammatory response; IEA:Ensembl.
DR   GO; GO:0007623; P:circadian rhythm; IEA:Ensembl.
DR   GO; GO:0050966; P:detection of mechanical stimulus involved in sensory perception of pain; IEA:Ensembl.
DR   GO; GO:0050965; P:detection of temperature stimulus involved in sensory perception of pain; IEA:Ensembl.
DR   GO; GO:0043303; P:mast cell degranulation; IEA:Ensembl.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IEA:Ensembl.
DR   GO; GO:0060073; P:micturition; IEA:Ensembl.
DR   GO; GO:0019228; P:neuronal action potential; IEA:Ensembl.
DR   GO; GO:0010737; P:protein kinase A signaling; IEA:Ensembl.
DR   GO; GO:0060004; P:reflex; IEA:Ensembl.
DR   GO; GO:0010996; P:response to auditory stimulus; IEA:Ensembl.
DR   GO; GO:0009408; P:response to heat; IEA:Ensembl.
DR   GO; GO:0009644; P:response to high light intensity; IEA:Ensembl.
DR   GO; GO:0071731; P:response to nitric oxide; IEA:Ensembl.
DR   GO; GO:0034695; P:response to prostaglandin E; IEA:Ensembl.
DR   GO; GO:0009636; P:response to toxic substance; IEA:Ensembl.
DR   GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR   GO; GO:0160025; P:sensory perception of itch; IEA:Ensembl.
DR   GO; GO:0060538; P:skeletal muscle organ development; IEA:Ensembl.
DR   GO; GO:1990770; P:small intestine smooth muscle contraction; IEA:Ensembl.
DR   GO; GO:0040040; P:thermosensory behavior; IEA:Ensembl.
DR   GO; GO:0001966; P:thigmotaxis; IEA:Ensembl.
DR   CDD; cd13433; Na_channel_gate; 1.
DR   Gene3D; 1.10.287.70; -; 4.
DR   Gene3D; 1.20.5.1190; iswi atpase; 1.
DR   Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR044564; Na_chnl_inactivation_gate.
DR   InterPro; IPR010526; Na_trans_assoc_dom.
DR   InterPro; IPR043203; VGCC_Ca_Na.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF210; SODIUM CHANNEL PROTEIN TYPE 11 SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW   Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT   TRANSMEM        130..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        161..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        200..218
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        253..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        377..399
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        578..596
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        608..629
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        700..724
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        787..812
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1058..1076
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1119..1141
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1167..1193
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1286..1309
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1359..1382
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1402..1420
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1432..1450
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1487..1515
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          128..409
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   DOMAIN          577..820
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   DOMAIN          828..1052
FT                   /note="Sodium ion transport-associated"
FT                   /evidence="ECO:0000259|Pfam:PF06512"
FT   DOMAIN          1056..1318
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   DOMAIN          1367..1558
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   REGION          472..492
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          407..434
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1705 AA;  194998 MW;  EC02F4E790E7A1D4 CRC64;
     MDDRCYPVIF PDERNFRPFT SDSLAAIEKR IAIQKEKKKS KDQTGEVPQP QPQLDLKASR
     KLPKLYGDIP RELIGKPLED LDPFYRNHKT FMVLNKKRTI YRFSAKRALF IFGPFNSIRS
     LAIRVSVHSL FSMFIIGTVI INCVFMATGP AKNSNSNNTD IAECVFTGIY IFEALIKILA
     RGFILDEFSF LRDPWNWLDS IVIGIAIVSY IPGITIQVSS LRTFRVFRAL KAISVVSRLK
     VIVGALLRSV KKLVNVIILT FFCLSIFALV GQQLFMGSLD LKCISRDCKI ISNLEAYDHC
     LEKKENSTEF KMCGTWMGNS ACSIQYECRH TKMNPDYNYT NFDNFGWSFL AMFRLMTQDS
     WEKLYQQTLR TTGLYSVFFF IVVIFLGSFY LINLTLAVVT MAYEEQNKNV AAEIEAKEKM
     FQEAQQLLKE EKEALVAMGI DRSSLTSLET SYFTPKKRKL FGNKKRKSFF LRESGKDQPP
     GSDSDEDSQK KPQLLEQTKR LSQNLSLDHF DEHGDPLQRQ RALSAVSILT ITMKEQEKSQ
     EPCLPCGENL ASKYLVWNCC PQWLCIKKVL RTVMTDPFTE LAITICIIIN TVFLAMEHHK
     MEESFEKMLN IGNSVFTGIF MAEMCLKIIA LDPYHYFRRG WNIFDSIVAL LSFADVISSK
     FEKGSWPFLR SFRVLRVFKL AKSWPTLNTL IKIIGNSVGA LGSLTVVLVI VIFIFSVVGM
     QLFGHSFNSR KSKKLCGLTG PTVSCLRHWH MGDFWHSFLV VFRILCGEWI ENMWECMQEA
     NGSSSSLCVI VFILITVIGK LVVLNLFIAL LLNSFSNEER NGNLEGEARK TKVQLALDRF
     RRGFCFVRHI LEHFCHKWCR KQNLPQQKEV TGGCAAQSKD IIHLVMEMKR SSETQEELGI
     LTSVPKTLGV RHDWTWLAPL AEEEDDVEFS GEDNAQRITQ PEAEQQAYEL HQENKKPTSQ
     RVQSVEIDMF SEDEPHLTIQ DPRKKSDVTS ILSECSTIDL QDGFGWLPEM VPKKEPERCL
     PKGFGCCFPC CSLDKRKPPW VIWWNLRKTC YQIVKHSWFE SFIIFVILLS SGALIFEDVH
     LEKQPKIQEL INCTDIIFTY IFIGEMVLKW VAFGFGKYFT SAWCCLDFII VIISVTTLIN
     LKELKSFRTL RALRPLRALS QFEGMKVVVN ALIGAIPAIL NVLLVCLIFW LIFCILGVHF
     FSGKFGKCIN GTDSVINYTI ITNKSQCESG NFSWINQKVN FDNVGNAYLA LLQVATFKGW
     MDIIYAAVDS REKEQQPEFE SNSFGYIYFV VFIIFGSFFT LNLFIGVIID NFNQQQKKLG
     GQDIFMTEEQ KKYYNAMKKL GSKKPQKPIP RPLNKCQGLV FDVVTSQIFD IVIISLIILN
     MISMMAESNN QPEAMKSILD HLNLVFVVIF TLECLIKIFA LRQYYFTNGW NLFDCVVVLL
     SIVSTMISTL EKQEYIPFPP TLFRIVRLAR IGRILRLVRA ARGIRTLLFA LMMSLPSLFN
     IGLLLFLIMF IYAILGMNWF SKVNPESGID DIFNFKTFAS SMLCLFQIST SAGWDSLLSL
     SDFADALPEP LRVAKPNKYQ FLVMDLPMVS GDRLHCMDIL FAFTARVLGG SDGLDSMKTM
     MEEKFMEANP LKKLYEPIVT TTKRKEEERG AAIIQKAFRK YMMKVTKGDQ GDQNDLENRP
     HSPLQTLCNG DLSSFGVAKG KVHCD
//
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