ID G1R2M7_NOMLE Unreviewed; 288 AA.
AC G1R2M7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 24-JAN-2024, entry version 76.
DE SubName: Full=Protein activator of interferon induced protein kinase EIF2AK2 {ECO:0000313|Ensembl:ENSNLEP00000007449.2};
GN Name=PRKRA {ECO:0000313|Ensembl:ENSNLEP00000007449.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000007449.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000007449.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000007449.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC {ECO:0000256|ARBA:ARBA00004556}.
CC -!- SIMILARITY: Belongs to the PRKRA family.
CC {ECO:0000256|ARBA:ARBA00005856}.
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DR EMBL; ADFV01058884; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003253828.1; XM_003253780.3.
DR AlphaFoldDB; G1R2M7; -.
DR SMR; G1R2M7; -.
DR STRING; 61853.ENSNLEP00000007449; -.
DR Ensembl; ENSNLET00000007815.2; ENSNLEP00000007449.2; ENSNLEG00000006120.2.
DR eggNOG; KOG3732; Eukaryota.
DR GeneTree; ENSGT00940000157618; -.
DR HOGENOM; CLU_048292_0_0_1; -.
DR InParanoid; G1R2M7; -.
DR OMA; HRKEFTI; -.
DR TreeFam; TF315953; -.
DR Proteomes; UP000001073; Chromosome 22a.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0034599; P:cellular response to oxidative stress; IEA:Ensembl.
DR GO; GO:0042474; P:middle ear morphogenesis; IEA:Ensembl.
DR GO; GO:0042473; P:outer ear morphogenesis; IEA:Ensembl.
DR GO; GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProtKB-KW.
DR GO; GO:0048705; P:skeletal system morphogenesis; IEA:Ensembl.
DR CDD; cd19889; DSRM_PRKRA_rpt1; 1.
DR CDD; cd19891; DSRM_PRKRA_rpt2; 1.
DR CDD; cd19892; DSRM_PRKRA_rpt3; 1.
DR Gene3D; 3.30.160.20; -; 3.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR044465; PRKRA_DSRM_1.
DR InterPro; IPR044466; PRKRA_DSRM_2.
DR InterPro; IPR044467; PRKRA_DSRM_3.
DR PANTHER; PTHR46205:SF2; INTERFERON-INDUCIBLE DOUBLE-STRANDED RNA-DEPENDENT PROTEIN KINASE ACTIVATOR A; 1.
DR PANTHER; PTHR46205; LOQUACIOUS, ISOFORM B; 1.
DR Pfam; PF00035; dsrm; 2.
DR SMART; SM00358; DSRM; 3.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 3.
DR PROSITE; PS50137; DS_RBD; 3.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00266}.
FT DOMAIN 9..76
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 101..169
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 215..283
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
SQ SEQUENCE 288 AA; 31635 MW; E663866BAB6DF0BC CRC64;
MITAKPGKTP IQVLHEYGMK TKNIPVYECE RSDVQIHVPT FTFRVTVGDI TCTGEGTSKK
LAKHRAAEAA INILKANASI CFAVPDPLMP DPSKQPKNQL NPIGSLQELA IHHGWRLPEY
TLSQEGGPAH KREYTTICRL ESFMETGKGA SKKQAKRNAA EKFLAKFSNI SPENHISLTN
VVGHSLGCTW HSLRNSPGEK INLLKRSLLS IPNTDYIQLL SEIAKEQGFN ITYLDIDELS
ANGQYQCLAE LSTSPITVCH GSGISCGNAQ SDAAHNALQY LKIIAERK
//