ID   G1R6F2_NOMLE            Unreviewed;       928 AA.
AC   G1R6F2;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   27-MAR-2024, entry version 58.
DE   SubName: Full=Inter-alpha-trypsin inhibitor heavy chain 4 {ECO:0000313|Ensembl:ENSNLEP00000008774.2};
GN   Name=ITIH4 {ECO:0000313|Ensembl:ENSNLEP00000008774.2};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000008774.2, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000008774.2, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000008774.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the ITIH family.
CC       {ECO:0000256|ARBA:ARBA00010158}.
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DR   EMBL; ADFV01173480; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; G1R6F2; -.
DR   STRING; 61853.ENSNLEP00000008774; -.
DR   Ensembl; ENSNLET00000009192.3; ENSNLEP00000008774.2; ENSNLEG00000007192.3.
DR   eggNOG; ENOG502QPS2; Eukaryota.
DR   GeneTree; ENSGT00940000161039; -.
DR   HOGENOM; CLU_008101_0_0_1; -.
DR   InParanoid; G1R6F2; -.
DR   OMA; EFIYWIN; -.
DR   TreeFam; TF328982; -.
DR   Proteomes; UP000001073; Chromosome 4.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0006953; P:acute-phase response; IEA:Ensembl.
DR   GO; GO:0030212; P:hyaluronan metabolic process; IEA:InterPro.
DR   GO; GO:0034097; P:response to cytokine; IEA:Ensembl.
DR   CDD; cd01461; vWA_interalpha_trypsin_inhibitor; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR010600; ITI_HC_C.
DR   InterPro; IPR013694; VIT.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10338; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER; 1.
DR   PANTHER; PTHR10338:SF119; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H4; 1.
DR   Pfam; PF06668; ITI_HC_C; 1.
DR   Pfam; PF08487; VIT; 1.
DR   Pfam; PF00092; VWA; 1.
DR   SMART; SM00609; VIT; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS51468; VIT; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           29..928
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014113204"
FT   DOMAIN          19..148
FT                   /note="VIT"
FT                   /evidence="ECO:0000259|PROSITE:PS51468"
FT   DOMAIN          276..459
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          597..620
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        602..616
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   928 AA;  102719 MW;  A492AC0212DF0E26 CRC64;
     MKPSRPVCTC SKVLVLLSLL AIHQTTTAQK NGVDIYSLTV DSRVSSRFAH TVVTSRVVNR
     ANTVQEATFQ MELPKKAFIT NFSMIIDGMT YPGIIKEKAE AQAQYSAAVA KGKSAGLVKA
     TGRNMEQFQV SVSVAPNAKI TFELVYEELL KRRLGVYELL LKVRPQQLGP TSCLQMDIHI
     FEPQGISFLE TESTFMTNQL VDALTTWQNK TKAHIRFKPT LSQQQKSPEQ QETVLDGNLI
     IRYDVDRAIS GGSIQIENGY FVHYFAPEGL TAMPKNVVFV IDKSGSMSGR KIQQTREALI
     KILDDLSPRD QFNLIVFSTE AIQWRPSLVP ASAENVNKAR SFAAGIQALG GTNINDAMLM
     AVQLLDSSNQ EERLPDGSVS LIILLTDGDP TVGETNPRSI QKNVREAVSG RYSLFCLGFG
     FDVSYAFLEK LALDNGGLAR RIHEDSDSAL QLQDFYQEVA NPLLTAVTFE YPSNAVEEVT
     QNNFRLLFKG SEMVVAGKLQ DQGPDVLTAT VSGKLPTQNI TFQTESSVAE QEADFQSPKY
     IFHNFMERLW AYLTIQQLLE QTVSASDADQ QALRTQALNL SLAYSFVTPL TSMVVTKPED
     QEQSQVAEKP VEGESRNRNV HSGSTFFKYY LQGAKIPKPG LDHTEASFSP RRGWSRQAGA
     AVSRMNFRPG VLSPRQVGLP GPPDAPDHAA LHPFRRLAIS PALAPPATSN PDPAVSRVMN
     TKIKAPIQAP SAILPLPGQS VERLCVDPRH RQGPVNLLSD PEQGVEVTGQ YEREKTGFSW
     IEVTFKNPPV RVHASPEHVV VTRNRRSSAY KWKETLFSVM PGLKMTMDKT GLLLLSDPDR
     VTIGLLFWDG RGEGLRLLLR DTDRFSSHVG GTLGQFYQEV LWGSPAASDD GRRMLRVQGS
     DHSATRERRL DYQEGPPGVE ISCWSVEL
//