ID G1R714_NOMLE Unreviewed; 366 AA.
AC G1R714;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 3.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Transmembrane protein 25 {ECO:0000313|Ensembl:ENSNLEP00000008986.3};
GN Name=TMEM25 {ECO:0000313|Ensembl:ENSNLEP00000008986.3};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000008986.3, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000008986.3, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000008986.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01057011; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01057012; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01057013; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012351330.1; XM_012495876.1.
DR AlphaFoldDB; G1R714; -.
DR STRING; 61853.ENSNLEP00000008986; -.
DR Ensembl; ENSNLET00000009410.3; ENSNLEP00000008986.3; ENSNLEG00000007367.3.
DR GeneID; 100586180; -.
DR CTD; 84866; -.
DR eggNOG; KOG4555; Eukaryota.
DR GeneTree; ENSGT01080000257333; -.
DR HOGENOM; CLU_048525_1_0_1; -.
DR InParanoid; G1R714; -.
DR OMA; CVCLGRW; -.
DR TreeFam; TF333068; -.
DR Proteomes; UP000001073; Chromosome 15.
DR GO; GO:0005770; C:late endosome; IEA:Ensembl.
DR GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0090394; P:negative regulation of excitatory postsynaptic potential; IEA:Ensembl.
DR GO; GO:0031647; P:regulation of protein stability; IEA:Ensembl.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR042864; TMEM25.
DR PANTHER; PTHR47224; TRANSMEMBRANE PROTEIN 25; 1.
DR PANTHER; PTHR47224:SF1; TRANSMEMBRANE PROTEIN 25; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..366
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014129975"
FT TRANSMEM 235..261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 30..123
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 298..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 366 AA; 39356 MW; 269C6D8462B69189 CRC64;
MALPQSPAAL RHTLLLLPAL LSSGWGELEP QIDGQTWAER ALRENERHAF TCRVAGGPGT
PRLAWYLDGQ LQEASTSRLL SVGGEAFSGG TSTFTVTAHR AQHELNCSLQ DPSSGRSANA
SVILNVQFKP EIAQVGAKYQ EAQGPGLLVV LFALVRANPP ANVTWIDQDG PVTVNTSDFL
VLDAQNYPWL TNHTVQLQLR SLAHNLSVVA TNDVGVTSAS LPAPGLLATR VEVPLLGIVV
AAGLALGTLV GFSTLVACLV CRKEKKTKGP SRRPSLISSD SNNLKLNNVR LPRENMSLPS
NLQLNDLTPD SRAVKPADRQ MAQNNSRPEL LDPEPGGLLT SRGFIRLPML GYIYRVSSVS
SDEIWL
//
