ID G1R990_NOMLE Unreviewed; 842 AA.
AC G1R990;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Follistatin like 4 {ECO:0000313|Ensembl:ENSNLEP00000009779.1};
GN Name=FSTL4 {ECO:0000313|Ensembl:ENSNLEP00000009779.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000009779.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000009779.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000009779.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; ADFV01032633; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01032634; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01032635; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01032636; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01032637; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01032638; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01032639; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01032640; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01032641; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01032642; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1R990; -.
DR STRING; 61853.ENSNLEP00000009779; -.
DR Ensembl; ENSNLET00000010250.2; ENSNLEP00000009779.1; ENSNLEG00000008014.2.
DR eggNOG; ENOG502QPNV; Eukaryota.
DR GeneTree; ENSGT00940000158076; -.
DR HOGENOM; CLU_007849_0_0_1; -.
DR InParanoid; G1R990; -.
DR OMA; RYLPVCG; -.
DR TreeFam; TF350473; -.
DR Proteomes; UP000001073; Chromosome 2.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00096; Ig; 1.
DR CDD; cd05736; IgI_2_Follistatin_like; 1.
DR CDD; cd00104; KAZAL_FS; 1.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR10913; FOLLISTATIN-RELATED; 1.
DR PANTHER; PTHR10913:SF9; FOLLISTATIN-RELATED PROTEIN 4; 1.
DR Pfam; PF13927; Ig_3; 2.
DR Pfam; PF07648; Kazal_2; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SMART; SM00280; KAZAL; 1.
DR SUPFAM; SSF75011; 3-carboxy-cis,cis-mucoante lactonizing enzyme; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..842
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003420706"
FT DOMAIN 81..135
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 174..209
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 251..338
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 341..426
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 842 AA; 93098 MW; D0A2FC55F4B12394 CRC64;
MKPGGFWLHL TLLGASLPAV LGWTDPGTSR GPDVGVGESQ AEEPRSFEVT RREGLSSHNE
LLASCGKKFC SRGSRCVLSR KTGEPECQCL EACRPSYVPV CGSDGRFYEN HCKLHRAACL
LGKRITVIHS KDCFLKGDKC TMAGYARLKN VLLALQTRLQ PLQEGDSRQD PASQKHLLVE
SLFRDLDADG NGHLSSSELA QHVLKKQDLD EDLLGCSPGD LLRFDDYNSD SSLTLREFYM
AFQVVQLSLA PEDRVSVTTV TVGLSTVLTC AVRGDLRPPI IWKRNGLTLN FLELEDINDF
GEDDSLYITK VTTVHMGNYT CHASGHEQLF QTHVLQVNVP PVIRVYPESQ AQEPGVAASL
RCHAEGIPMP RITWLKNGVD VSTQMSKQLS LLANGSELHI SSVRYEDTGA YTCIAKNEVG
VDEDISSLFI EDSARKTLAN ILWREEGLSV GNMFYVFSDD GIIVIHPVDC EIQRHLKPTE
KIFMSYEEIC PQREKNATQP CQWVSAVNVR NRYIYVAQPA LSRVLVVDIQ AQKVLQSIGV
DPLPAKLSYD KSHDQVWVLS WGDVHKSQPS LQVITEASAG QGQHLIRTPF AGVDDFFIPP
TNLIINHIRF GFIFNKSDPA VHKVDLETMM PLKTIGLHHH GCVPQAMAHT HLGGYFFIQC
QQDSPISAAR QLLVDSVTDS VLGPNGDVTG TPHTSPDGRF IVSAAADSPW LHVQEITLQG
EIQTLYDLQI NSGISDLAFQ RSFTESNQYN IYAALHTEPD LLFLELSTGK VGMLKNLKEP
PTGPSQPWGD ARRIMRDSGL FGQYLLTPAQ ESLFLINGRQ NTLRCEVSGI KGGTTVVWVG
EV
//
