ID G1RBV8_NOMLE Unreviewed; 647 AA.
AC G1RBV8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 3.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Pumilio RNA binding family member 3 {ECO:0000313|Ensembl:ENSNLEP00000010707.3};
GN Name=PUM3 {ECO:0000313|Ensembl:ENSNLEP00000010707.3};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000010707.3, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000010707.3, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000010707.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ADFV01078780; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01078781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003273918.1; XM_003273870.2.
DR AlphaFoldDB; G1RBV8; -.
DR STRING; 61853.ENSNLEP00000010707; -.
DR Ensembl; ENSNLET00000011225.2; ENSNLEP00000010707.3; ENSNLEG00000008712.2.
DR GeneID; 100583872; -.
DR KEGG; nle:100583872; -.
DR CTD; 9933; -.
DR eggNOG; KOG2050; Eukaryota.
DR GeneTree; ENSGT00390000015757; -.
DR HOGENOM; CLU_013994_0_1_1; -.
DR InParanoid; G1RBV8; -.
DR OMA; YGPEFSI; -.
DR OrthoDB; 5488678at2759; -.
DR TreeFam; TF312954; -.
DR Proteomes; UP000001073; Chromosome 1a.
DR GO; GO:0005694; C:chromosome; IEA:Ensembl.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR012959; CPL_dom.
DR InterPro; IPR033133; PUM-HD.
DR InterPro; IPR040059; PUM3.
DR InterPro; IPR001313; Pumilio_RNA-bd_rpt.
DR PANTHER; PTHR13389:SF0; PUMILIO HOMOLOG 3; 1.
DR PANTHER; PTHR13389; UNCHARACTERIZED; 1.
DR Pfam; PF08144; CPL; 1.
DR SMART; SM00025; Pumilio; 6.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS50302; PUM; 2.
DR PROSITE; PS50303; PUM_HD; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 136..509
FT /note="PUM-HD"
FT /evidence="ECO:0000259|PROSITE:PS50303"
FT REPEAT 200..235
FT /note="Pumilio"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00317"
FT REPEAT 423..459
FT /note="Pumilio"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00317"
FT REGION 1..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..123
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 647 AA; 73453 MW; 7D479CE2F38515C4 CRC64;
MEVKGKKQFT GKSTKTAQEK NRFHKNSDSG SSKAFPRKVA KEGGPKITSR NFEKSITKPG
KKGVKQFKNK QQGDKSPKNK FQQANKFNKK RKFQPDGKSD ESAAKKPKWD DFKKKKKELK
QSRQLSDKTN YDIVVRAKQI WEILRRKDCD KEKRLKLMSD LQKLIQGKIK TIAFAHDSTR
VIQCYIQYGN EEQRKQAFEE LRDDLVELSK AKYSRNIVKK FLMYGSKPQI AEIIRSFKGH
VRKMLRHAEA SAIVEYAYND KAILEQRNML TEELYGNTFQ LYKSADHPTL DKVLEVQPEK
LELIMDEMKQ ILTPMAQKEA VIKHSLVHKV FLDFFTYAPS KLRSEMIEAI REAVVYLAHT
HDGARVAMHC LWHGTPKDRK VIVKTMKTYI EKVANGQYSH LVLLAAFDCI DDTKLVKQII
ISEIISSLPS IVNDKYGRKV LLYLLSPRDP AHTVREIIEV LQKGDGNAHS KKDTEVRRRE
LLESISPALL SYLQEHAQEV VLDKSACVLV SDILGSATGD VQPAMNVIAS LAATELHPGG
KDGELHIAEH PAGHLVLKWL IEQDKKMKEN GREGCFAKTL VEHVGMKNLK SWASVNRGAI
ILSSLLQSCD LEVANKVKAA LKSLIPTLEK TKSTSKGIET LLEKLST
//
