ID G1RC94_NOMLE Unreviewed; 968 AA.
AC G1RC94;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 3.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=Testis anion transporter 1 {ECO:0000256|RuleBase:RU362052};
DE AltName: Full=Solute carrier family 26 member 8 {ECO:0000256|RuleBase:RU362052};
GN Name=SLC26A8 {ECO:0000313|Ensembl:ENSNLEP00000010843.3};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000010843.3, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000010843.3, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000010843.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|ARBA:ARBA00008692, ECO:0000256|RuleBase:RU362052}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ADFV01115237; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01115238; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01115239; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01115240; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01115241; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01115242; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01115243; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01115244; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01115245; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01115246; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1RC94; -.
DR STRING; 61853.ENSNLEP00000010843; -.
DR Ensembl; ENSNLET00000011372.2; ENSNLEP00000010843.3; ENSNLEG00000008819.3.
DR eggNOG; KOG0236; Eukaryota.
DR GeneTree; ENSGT01100000263544; -.
DR HOGENOM; CLU_003182_9_3_1; -.
DR InParanoid; G1RC94; -.
DR OMA; RINKCIK; -.
DR TreeFam; TF313784; -.
DR Proteomes; UP000001073; Chromosome 1a.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0097227; C:sperm annulus; IEA:Ensembl.
DR GO; GO:0005254; F:chloride channel activity; IEA:Ensembl.
DR GO; GO:0019531; F:oxalate transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0160044; F:sulfate:chloride antiporter activity; IEA:Ensembl.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR PANTHER; PTHR11814:SF11; TESTIS ANION TRANSPORTER 1; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|RuleBase:RU362052};
KW Differentiation {ECO:0000256|RuleBase:RU362052};
KW Meiosis {ECO:0000256|RuleBase:RU362052};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Spermatogenesis {ECO:0000256|RuleBase:RU362052};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 91..108
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 147..165
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 195..219
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 231..254
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 266..291
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 312..329
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 357..376
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 449..470
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 490..516
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 543..795
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
FT REGION 819..968
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 829..851
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 857..872
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 873..896
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 930..945
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 968 AA; 108746 MW; B32D0E0BF7824D8C CRC64;
MAQLERNAIS GFSSKSRRNS FAYDVKREVY NEETFQQEHK RKSSSSGNMN INITTFRHHV
QCCCSWHRFL RCMLTIFPFL EWMCMYRLKD WLLGDLLAGI SVGLVQVPQG LTLSLLARQL
IPPLNIAYAA FCSSVIYVIF GSCHQMSIGS FFLVSALLIN VLKVSPFNNG QLVMGSFIKD
EFSAPSYLMG YNKSLSVVAT TTFLTGIIQL IMGVLRLGFI ATYLPESAMS AYLAAVALHI
MLSQLTCIFG IMISFHAGPI SFFYDIINYC VALPKANSTS ILLFLTVVVA LRINKCIRIS
FNQYPIEFPM ELFLIIGFTV IANKISMATE TSQTLIDMIP YSFLFPVTPD FGLLPKIILQ
AFSLSLVSSF LLIFLGKKIG SLHNYSVNSN QDLIAIGLCN VVSSFFRSCV FTGAVARTII
QDKSGGRQQF ASLVGAGVML LLMVKMGHFF YALPNAVLAG IILSNVVPYL ETISNLPSLW
RQDRYDCALW MMTFSSSIFL GLDIGLIISV VSAFFITTVR SHRAKILLLG QIPNTNIYRS
INDYREIITI PGVKIFQCCS SITFVNVYYL KHKLLKEVDM VRVPLKEEEI FSLFNSSDTN
LQGEKICRCF CNCDDLEPLP RILYTERFEN KLDPNASSVN LIHCSHFESM NTSQTASEDQ
VPYTVSSVSQ KNQGQQYEEV EKVWLPDNTS RNSSPGLPDV AESQGRRSLI PYSDVSPLPS
VHTIILDFSM VHYVDSRGLV VLRQICNAFQ NANILILIAG CHSSIVRAFE RNDFFDAGIT
KTQLFLSVHD AVLFALSRKV IGSSKLSIDE SETVIRETYS ETDKNDNSTH KMSSSFLGSQ
KNVSPGFTKI QQPVEEESEL DLELESEQEA GLGLDLDLDR ELEPEIEPKA ETETETEMEP
QPETEPEMEP DPKSRPRAHT FPQQHYWPMC HPSMASTQSQ TQPRTWSVER RRHPMDSYSP
EGNSNEDV
//
