ID G1RD25_NOMLE Unreviewed; 1470 AA.
AC G1RD25;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=NLR family pyrin domain containing 1 {ECO:0000313|Ensembl:ENSNLEP00000011124.2};
GN Name=NLRP1 {ECO:0000313|Ensembl:ENSNLEP00000011124.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000011124.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000011124.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000011124.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Inflammasome
CC {ECO:0000256|ARBA:ARBA00004110}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ADFV01082431; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01082432; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01082433; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01082434; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01082435; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01082436; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 61853.ENSNLEP00000011124; -.
DR Ensembl; ENSNLET00000011675.3; ENSNLEP00000011124.2; ENSNLEG00000009130.3.
DR eggNOG; ENOG502S4A4; Eukaryota.
DR GeneTree; ENSGT00940000162176; -.
DR HOGENOM; CLU_002274_2_4_1; -.
DR InParanoid; G1RD25; -.
DR OMA; SWMVCTC; -.
DR TreeFam; TF340267; -.
DR Proteomes; UP000001073; Chromosome 19.
DR GO; GO:0072558; C:NLRP1 inflammasome complex; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:Ensembl.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:Ensembl.
DR GO; GO:0140608; F:cysteine-type endopeptidase activator activity; IEA:Ensembl.
DR GO; GO:0003690; F:double-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
DR GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR GO; GO:0140693; F:molecular condensate scaffold activity; IEA:Ensembl.
DR GO; GO:0038187; F:pattern recognition receptor activity; IEA:Ensembl.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR GO; GO:0043621; F:protein self-association; IEA:Ensembl.
DR GO; GO:0035591; F:signaling adaptor activity; IEA:Ensembl.
DR GO; GO:0140374; P:antiviral innate immune response; IEA:Ensembl.
DR GO; GO:0071493; P:cellular response to UV-B; IEA:Ensembl.
DR GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
DR GO; GO:1904784; P:NLRP1 inflammasome complex assembly; IEA:Ensembl.
DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0032731; P:positive regulation of interleukin-1 beta production; IEA:Ensembl.
DR GO; GO:0051260; P:protein homooligomerization; IEA:Ensembl.
DR GO; GO:0070269; P:pyroptosis; IEA:Ensembl.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0097264; P:self proteolysis; IEA:Ensembl.
DR GO; GO:0031098; P:stress-activated protein kinase signaling cascade; IEA:Ensembl.
DR CDD; cd08330; CARD_ASC_NALP1; 1.
DR CDD; cd08320; Pyrin_NALPs; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR033516; CARD8/ASC/NALP1_CARD.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR025307; FIIND_dom.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46985; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR46985:SF3; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF13553; FIIND; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00368; LRR_RI; 5.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS51830; FIIND; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammasome {ECO:0000256|ARBA:ARBA00023233};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Necrosis {ECO:0000256|ARBA:ARBA00022590};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 1..92
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 328..637
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT DOMAIN 1074..1361
FT /note="FIIND"
FT /evidence="ECO:0000259|PROSITE:PS51830"
FT DOMAIN 1377..1460
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT REGION 90..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 160..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 992..1022
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..230
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 997..1019
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1470 AA; 164756 MW; 8C14CFE78644A8D5 CRC64;
MAGGAWGRLA CYLEFLKKEE LKEFQLLLAN KAHSRSSSGE TPTQPEKTSG MEVASYLVAQ
YGEQRAWDLA LHTWEQMGLR SLCAQAQEGA GHSPSFPYSP SEPHLGSPSQ PTSTAVLMPW
ICELPAGCTQ GSERRVLRQL PDTSGRRWRE ISSSLLYQAL PSSPDHESPS QESPSAPTST
AVLGSWGSPP QPSPAPREQE APGTQWPLDE TSGNYYTEIR EREIEKSEKG RPPWAAAVGT
PPEVHASLQP HRHPWEPSGR ESLCSTWPWK NEDLNQKFTQ LLLLQRPHPR SQEPLVKESW
PPDVEEDRGH LIEIGDLFGP GLDTQEPRIV ILQGAAGIGK STLARQVREA WGRGQLYGDR
FQHVFYFSCR ELAQSKVVSL AELIAKDCTA AQAPIRQILS RPERLLFILD GVDEPGWVLQ
EPSSELCLHW SQPRPVDALL GSLLGKTILP EASFLITART TALQNLIPSL EQARWVEVLG
FSESSRKEYF YKYFTGERQA ITAFRLVKSN KELWALCLVP WVSWLACTCL MQQIKRKEKL
TLTSKTTTTL CLRYLSQALQ AQPLGPQLRD LCSLAAEGVW QKKTLFSPDD LRKHGLDGAI
ISTLLKMGIL QEHPIPLSYS FIHLCFQEFF AAMSYALEDK KGRGKHSNCI IHLEKLLEAY
GTHGLFGAPT TRFLLGLLSD EGEREMKNIF HCRLSQGRKL MRWVPSLQPL LQPHSLEFLH
CLYETQNKTF LTQVMAHFQE LGMCVETDME LLVCTFCIKF SPHVKKLQLI EGRQHRPAWS
PTRVVLFRWA PVTDAYWQIL FSVLKVTRNL KELDLSGNSL SHSAVKSLCK TLRCPRCLLE
TLRLAGCGLT AQDCKDIASG LRANQTLTEL DLSFNVLRDA GAKRLCQTLR WPSCKLQRLQ
LVSCGLTSGC CQDLASMLST SSSLMGLDLQ QNNLGDAGVR LLREGLRHPA CQLTSLGLDQ
MTLSDEMRQQ LRALEQEKPQ LLIFSRRKPS VMIPNEGMDT RETSNSTSSL TQQRLGSGSM
KGQEAGLEAL EGGSPDRQAE GSSPKVVLVE PLRTPSPASQ GDLLTKALGT DDDFWGPTGP
VATEIVDKER SLYRVHFPVA GSYRWPNTGL CFVVREAVTI EIEFCVWDQF LGEINPQQSW
MVAGPLLDIK AEPGAVEAVH LPHFVVLQGG RVDTSLFQVA HFKEEGMLLE KPARVELHHI
VLENPSFSPL GVLLKMIHNA LHFLPVTSMV LLYHRLHPEE ITFHLYLIPS DCSIRKAIDD
EEMKFQFVRI HKPPPLTPLY MGCRYTVSGS GSGSGMLEIL PKELELCYRS PGEDQLFSEF
YVGHLGSGIR LQLKDKKDET LVWEALVKPG DLMPATTVVP PACIGLPSPL DAPRLLHFVD
QYREQLIARV TSVEVVLDKL HGQVLSQEQY ERVLAEDTRP SQMRKLFSLS QSWDRRCKDG
LYQALKETHP YLIMELWEKG SKKGLLPLSS
//
