ID G1REY0_NOMLE Unreviewed; 1102 AA.
AC G1REY0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=NLR family CARD domain containing 3 {ECO:0000313|Ensembl:ENSNLEP00000011780.2};
GN Name=NLRC3 {ECO:0000313|Ensembl:ENSNLEP00000011780.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000011780.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000011780.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000011780.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01048449; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01048450; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01048451; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01048452; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01048453; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01048454; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01048455; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01048456; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01048457; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01048458; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1REY0; -.
DR STRING; 61853.ENSNLEP00000011780; -.
DR Ensembl; ENSNLET00000012360.2; ENSNLEP00000011780.2; ENSNLEG00000009681.2.
DR eggNOG; KOG4308; Eukaryota.
DR GeneTree; ENSGT00940000159861; -.
DR HOGENOM; CLU_002274_3_0_1; -.
DR InParanoid; G1REY0; -.
DR OMA; DFTQVET; -.
DR TreeFam; TF329403; -.
DR Proteomes; UP000001073; Chromosome 18.
DR GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0007249; P:canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0043124; P:negative regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:1900226; P:negative regulation of NLRP3 inflammasome complex assembly; IEA:Ensembl.
DR GO; GO:1901223; P:negative regulation of non-canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0032720; P:negative regulation of tumor necrosis factor production; IEA:Ensembl.
DR GO; GO:0042110; P:T cell activation; IEA:Ensembl.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF285; NLR FAMILY CARD DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF13516; LRR_6; 10.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM00368; LRR_RI; 13.
DR SUPFAM; SSF52047; RNI-like; 2.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 184..316
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 79..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1102 AA; 118577 MW; 40946472682E262F CRC64;
MDAPRPPSLG VPGAASRPER LLDGGHGRQQ VQALSSQLLD VIPDSMRKQE VRTGREAGQG
HGTGSPAEQV KALMDLLAGK GSQGSPAPQA PERTPDAPLG PCSNDSRIQR HRKALLSKVG
GGPELGRPWH RLASLLLVEG LTDLQLREHD FTQVEPTRGG GRPARTVALD RLFLPLSRVS
VPPRVSITVG VAGMGKTTLV RHFVRLWAHG QVGKDFSLVL PLTFRDLNTH EKLCADRLIC
SVFPHVREPS LAVAVPARAL LILDGLDECR TPLDFSNTVA CTDPKKEIPV DHLITNIIRG
NLFPEVSIWI TSRPSASGQI PGGLVDRMTE IRGFNEEEIK VCLEQMFPED QALLDWMLSQ
VQADRALYLM CTVPAFCRLT GAALGHLWRS RTGPQNAELW PPRTLCELYS WYFRMALSGE
GQEKGKASPR IEQVAHGGRK MVGTLGRLAF HGLLKKKYVF YEQDMKAFGV DLALLQGAPC
SCFLQREETL ASSVAYCFTH LSLQEFVAAA YYYGASRRSI FDLFTESSVS WPRLGFLTHF
RSAAQRAMQA EDGRLDVFLR FLSGLLSPRV NALLAGSLLA QGEHQAYRTQ VAELLQGCLR
PDAAVCAQAI NILHCLHELQ HTELARGVEE AMESGALARL TGPAHRAALA YLLQVSDTCA
QEANLSLSLS QGVLQSLLPQ LLYCRKLMLD TNQFQDPVME LLGSVLSGKD CRIQKISLAE
NQISNKGAKA LARSLLVNRS LTSLDLRSNS IGPQGAKALA DALKINRTLT SLSLQGNTVR
DDGARSVAEA LASTRTLSML HLQKNSIGPM GAQQMADALK QNRSLKELML SSNSIGDGGA
KALAEALKVN QGLESLDLQS NSISDAGVAA LMGALCTNQT LLILATLSKQ AQAIAHALCA
NSTLNLTANL LHDQGARAIA VAVRENRTLT SLHLQWNFIQ AGAAQALGQA LQLNRSLTSL
DLQENAIGDD GACAVARALK VNTALTALYL QVASIGAPGA QVLGEALAVN RTLEILDLRG
NAIGVAGAKA LANALKVNSS LRRLNLQENS LGMDGAICIA TALSGNHRLQ HINLQGNHVG
DSGARMISEA IKTNAPTCTV EM
//
