ID G1RG51_NOMLE Unreviewed; 1297 AA.
AC G1RG51;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=SET domain bifurcated histone lysine methyltransferase 1 {ECO:0000313|Ensembl:ENSNLEP00000012201.2};
GN Name=SETDB1 {ECO:0000313|Ensembl:ENSNLEP00000012201.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000012201.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000012201.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000012201.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; ADFV01183126; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01183127; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01183128; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01183129; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01183130; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01183131; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01183132; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 61853.ENSNLEP00000012201; -.
DR Ensembl; ENSNLET00000012798.3; ENSNLEP00000012201.2; ENSNLEG00000009996.3.
DR eggNOG; KOG1141; Eukaryota.
DR GeneTree; ENSGT00940000157471; -.
DR HOGENOM; CLU_003279_1_0_1; -.
DR InParanoid; G1RG51; -.
DR OMA; IRAVTNC; -.
DR TreeFam; TF106411; -.
DR Proteomes; UP000001073; Chromosome 12.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0140938; F:histone H3 methyltransferase activity; IEA:UniProt.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:UniProt.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd01395; HMT_MBD; 1.
DR CDD; cd20382; Tudor_SETDB1_rpt1; 1.
DR CDD; cd21181; Tudor_SETDB1_rpt2; 1.
DR Gene3D; 2.30.30.140; -; 3.
DR Gene3D; 2.170.270.10; SET domain; 2.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR040880; DUF5604.
DR InterPro; IPR025796; Hist-Lys_N-MeTrfase_SETDB1.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR007728; Pre-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR047232; SETDB1/2-like_MBD.
DR InterPro; IPR002999; Tudor.
DR InterPro; IPR041292; Tudor_4.
DR InterPro; IPR041291; TUDOR_5.
DR PANTHER; PTHR46024; HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS; 1.
DR PANTHER; PTHR46024:SF2; HISTONE-LYSINE N-METHYLTRANSFERASE SETDB1; 1.
DR Pfam; PF18300; DUF5604; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF05033; Pre-SET; 1.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF18358; Tudor_4; 1.
DR Pfam; PF18359; Tudor_5; 1.
DR SMART; SM00391; MBD; 1.
DR SMART; SM00468; PreSET; 1.
DR SMART; SM00317; SET; 1.
DR SMART; SM00333; TUDOR; 2.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50867; PRE_SET; 1.
DR PROSITE; PS51573; SAM_MT43_SUVAR39_1; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 693..793
FT /note="Pre-SET"
FT /evidence="ECO:0000259|PROSITE:PS50867"
FT DOMAIN 796..1272
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 1281..1297
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 108..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 408..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 861..1153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..123
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..473
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..540
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 886..903
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 908..940
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 944..960
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 965..1000
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1027..1046
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1071..1133
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1297 AA; 144179 MW; 6012617E7912D029 CRC64;
MSSLPGCIGL DAATATVESE EMAELQQAVV EELGISMEEL RHFIDEELEK MDCVQQRKKQ
LAELETWVIQ KESEVAHVDQ LFDDASRAVT NCESLVKDFY SKLGLQYRDS SSEDESSRPT
EIIEIPDEDD DVLSIDSGDA GSRTPKDQKL REAMAALRKS AQDVQKFMDA VNKKSSSQDL
HKGTLSQMSG ELSKDGDLIV SMRILGKKRT KTWHKGTLIA IQTVGPGKKY KVKFDNKGKS
LLSGNHIAYD YHPPADKLYV GSRVVAKYKD GNQVWLYAGI VAETPNVKNK LRFLIFFDDG
YASYVTQSEL YPICRPLKKT WEDIEDISCR DFIEEYVTAY PNRPMVLLKS GQLIKTEWEG
TWWKSRVEEV DGTISLRSFL SIPQDDKRCE WIYRGSTRLE PMFSMKTSSA SALEKKQGQL
RTRPNMGAVR SKGPVVQYTQ DLTGTGTQFK PVELPQPTAP PAPPFPPAPP LSPQAGDSES
LESQLAQSRK QVAKKSTSFR PGSVGSGHSS PTSPALSENV SGGKPGINQM YRSPLGSTAS
APAPSALPAP PAPPAFHGML ERAPAEPSYR APMEKLFYLP HVCSYTCLSR VRPMRNEQYR
GKNPRWPLLY DFRRMTARRR VNRKMGFHVI YKTPCGLCLR TMQEIERYLF ETGCDFLFLE
MFCLDPYVLV DRKFQPYKPF YYILDITYGK EDVPLSCVNE IDTTPPPQVA YSKERIPGKG
VFINTGFCFF WSKCACHQLT IQATACTPGG QINPNSGYQY KRLEECLPTG VYECNKRCKC
DPNMCTNRLV QHGLQVRLQL FKTQNKGWGI RCLDDIAKGS FVCIYAGKIL TDDFADKEGL
EMGDEYFANL DHIESVENFK EGYESDAPCS SDSSGVDLKD QEDGNSGTED PEESNDDSSD
DNFCKDEDFS TSSVWRSYAT RRQTRGQKEN GLSETTSKDS HPPDLGPPHI PVPPSIPVGG
CNPPSSEETP KNKVASWLSC NSVSEGGFAD SDSHSSFKTN EGGEGRAGGS RMEAEKAPTS
GLGIKDEGDI KQSKKEDPED RNKLSVVTES SRNYGYNPSP VKPEGLRRPP SKTSMHQSRR
LMASAQSNPD DVLTLSSSTE SEGESGTSRK PTAGQTSATA VDSDDIQTIS SGSEGDDFED
KKNMTGPMKR QVAVKSTRGF ALKSTHGIAI KSTNMASVDK GESAPVRKNT RQFYDGEESC
YIIDAKLEGN LGRYLNHSCS PNLFVQNVFV DTHDLRFPWV AFFASKAPLP FMIELHLHIQ
IRAGTELTWD YNYEVGSVEG KELLCCCGAI ECRGRLL
//
