ID G1RGB2_NOMLE Unreviewed; 236 AA.
AC G1RGB2;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Syntaxin 8 {ECO:0000313|Ensembl:ENSNLEP00000012262.1};
GN Name=STX8 {ECO:0000313|Ensembl:ENSNLEP00000012262.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000012262.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000012262.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000012262.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the syntaxin family.
CC {ECO:0000256|ARBA:ARBA00009063}.
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DR EMBL; ADFV01082894; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01082895; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01082896; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01082897; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01082898; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01082899; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01082900; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01082901; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01082902; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01082903; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003274715.1; XM_003274667.3.
DR AlphaFoldDB; G1RGB2; -.
DR STRING; 61853.ENSNLEP00000012262; -.
DR Ensembl; ENSNLET00000012860.2; ENSNLEP00000012262.1; ENSNLEG00000010055.2.
DR GeneID; 100593958; -.
DR KEGG; nle:100593958; -.
DR CTD; 9482; -.
DR eggNOG; KOG3202; Eukaryota.
DR GeneTree; ENSGT00390000007779; -.
DR HOGENOM; CLU_099972_1_0_1; -.
DR InParanoid; G1RGB2; -.
DR OMA; CYIAQEI; -.
DR OrthoDB; 3085987at2759; -.
DR TreeFam; TF323262; -.
DR Proteomes; UP000001073; Chromosome 19.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR GO; GO:0005770; C:late endosome; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0045335; C:phagocytic vesicle; IEA:Ensembl.
DR GO; GO:0055037; C:recycling endosome; IEA:Ensembl.
DR GO; GO:0005802; C:trans-Golgi network; IEA:Ensembl.
DR GO; GO:0019869; F:chloride channel inhibitor activity; IEA:Ensembl.
DR GO; GO:0019905; F:syntaxin binding; IEA:Ensembl.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:0071346; P:cellular response to type II interferon; IEA:Ensembl.
DR GO; GO:0045022; P:early endosome to late endosome transport; IEA:Ensembl.
DR GO; GO:1903076; P:regulation of protein localization to plasma membrane; IEA:Ensembl.
DR CDD; cd15852; SNARE_Syntaxin8; 1.
DR Gene3D; 1.20.5.110; -; 1.
DR InterPro; IPR045242; Syntaxin.
DR InterPro; IPR041875; Syntaxin-8_SNARE.
DR InterPro; IPR000727; T_SNARE_dom.
DR PANTHER; PTHR19957; SYNTAXIN; 1.
DR PANTHER; PTHR19957:SF285; SYNTAXIN-8; 1.
DR Pfam; PF05739; SNARE; 1.
DR SMART; SM00397; t_SNARE; 1.
DR SUPFAM; SSF58038; SNARE fusion complex; 1.
DR PROSITE; PS50192; T_SNARE; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 212..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 145..207
FT /note="T-SNARE coiled-coil homology"
FT /evidence="ECO:0000259|PROSITE:PS50192"
FT COILED 176..203
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 236 AA; 26894 MW; 9C64A0DA774CF38F CRC64;
MAPDPWFSTY DSTCQIAQEI AEKIQQRNQY ERKGEKAPKL TVTIRALLQN LKEKIALLKD
LLLRAVSTHQ ITQLEGDRRQ NLLDDLVTRE RLLLASFKNE GAEPDLIRSS LMSEEAKRGA
PNPWLFEEPE ETRGLGFDEI RQQQQKIIQE QDAGLDALSS IISRQKQMGQ EIGNELDEQN
EIIDDLANLV ENTDEKLRTE TRRVNMVDRK SASCGMIMVI LLLLVAIVVV AVWPTN
//
