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Database: UniProt
Entry: G1RII7_NOMLE
LinkDB: G1RII7_NOMLE
Original site: G1RII7_NOMLE 
ID   G1RII7_NOMLE            Unreviewed;      4344 AA.
AC   G1RII7;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   30-AUG-2017, entry version 41.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSNLEP00000013043};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSNLEP00000013043};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates
OS   leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hylobatidae; Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000013043};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000013043}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000013043}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSNLEP00000013043}.
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DR   EMBL; ADFV01073579; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01073580; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01073581; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01073582; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01073583; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01073584; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01073585; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01073586; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01073587; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01073588; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 61853.ENSNLEP00000013043; -.
DR   Ensembl; ENSNLET00000013682; ENSNLEP00000013043; ENSNLEG00000010690.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; G1RII7; -.
DR   OMA; HDECLTI; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000001073; Unplaced.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 9.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001073};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3658   3682       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3885   3905       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3953   3972       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4084   4102       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4145   4166       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4225   4248       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       61    272       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      488    684       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      730    942       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3394   3429       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4344 AA;  493112 MW;  C4AA2AA83E88192D CRC64;
     AALIRGNRNN CAQFSNNLDW LISKLDRLES SSGILEVLHC ILTESPEALN LIAEGHIKSI
     ISLLDKHGRN HKVLDILCSL CLCNGIAVRA NQNLICDNLL PRRNLLLQTR LINDVTSIRP
     NIFLGVAEGS AQYKKWYFEL IIDQVDPFLT AEPTHLRVGW ASSSGYAPYP GGGEGWGGNG
     VGDDLYSYGF DGLHLWSGRI PRAVASINQH LLRSDDVVSC CLDLGVPSIS FRINGQPVQG
     MFENFNTDGL FFPVMSFSAG VKVRFLMGGR HGEFKFLPPS GYAPCYEALL PKEKMRLEPV
     KEYKRDADGV RDLLGTTQFL SQASFIPCPI DTSQVVLPPH LEKIRDRLAE NIHELWGMNK
     IELGWTFGKI RDDNKRQHPC LVEFSKLPET EKNYNLQMST ETLKTLLALG CHIAHVNPAA
     EEDLKKVKLP KNYMMSNGYK PAPLDLSDVK LLPPQEILVD KLAENAHNVW AKDRIKQGWT
     YGIQQDLKNK RNPRLVPYAL LDERTKKSNR DSLREAVRTF VGYGYNIEPS DQELADSAVE
     KVSIDKIRFF RVERSYAVRS GKWYFEFEVV TGGDMRVGWA RPGCRPDVEL GADDQAFVFE
     GNRGQRWHQG SGYFGRTWQP GDVVGCMINL DDASMIFTLN GELLITNKGS ELAFADYEIE
     NGFVPICCLG LSQIGRMNLG TDASTFKFYT MCGLQEGFEP FAVNMNRDVA MWFSKRLPTF
     VNVPKDHPHI EVMRIDGTMD SPPCLKVTHK TFGTQNSNAD MIYCRLSMPV ECHSSFSHSP
     CLDSEAFQKR KQMQEILSHT TTQCYYAIRI FAGQDPSCVW VGWVTPDYHL YSEKFDLNKN
     CTVTVTLGDE RGRVHESVKR SNCYMVWGGD IVASSQRSNR SNVDLEIGCL VDLAMGMLSF
     SANGKELGTC YQVEPNTKVF PAVFLQPTST SLFQFELGKL KNAMPLSAAI FKSEEKNPVP
     QCPPRLDVQT IQPVLWSRMP NSFLKVETER VSERHGWVVQ CLEPLQMMAL HIPEENRCVD
     ILELCEQEDL MRFHYHTLRL YSAVCALGNS RVAYALCSHV DLSQLFYAID NKYLPGLLRS
     GFYDLLISIH LANAKERKLM MKNEYIIPIT STTRNIRLFP DESKRHGLPG VGLRTCLKPG
     FRFSTPCFVV TGEDHQKQSP EIPLESLRTK ALSMLTEAVQ CSGAHIRDPV GGSVEFQFVP
     VLKLIGTLLV MGVFDDDDVR QILLLIDPSV FGEHSAGTEE GAEKEDVSQV EEKAVEAGEK
     AGKEAPVKGL LQTRLPESVK LQMCELLSYL CDCELQHRVE AIVAFGDIYV SKLQANQKFR
     YNELMQALNM SAALTARKTK EFRSPPQEQI NMLLNFQLGE NCPCPEEIRE ELYDFHEDLL
     LHCGVPLEEE EEEEEDTSWT GKLCALVYKI KGPPKPEKEQ PTEEEERCPT TLKQLISQTM
     ICWAQEDQIQ DSELVRMMFN LLRRQYDSIG ELLQALRKTY TISHTSVSDT INLLAALGQI
     RSLLSVRMGK EEELLMINGL GDIMNNKVFY QHPNLMRVLG MHETVMEVMV NVLGTEKSQI
     AFPKMVASCC RFLCYFCRIS RQNQKAMFEH LSYLLENSSV GLASPSMRGS TPLDVAASSV
     MDNNELALSL EEPDLEKVVT YLAGCGLQSC PMLLAKGYPD VSWNPIEGER YLSFLRFAVF
     VNSESVEENA SVVVKLLIRR PECFGPALRG EGGNGLLAAM QGAIKISENP ALDLPSQGYK
     REVSTEDDEE EEEIVHMGNA IMSFYSALID LLGRCAPEMH LIQTGKGEAI RIRSILRSLV
     PTEDLVGIIS IPLKLPSLNK DGSVSEPDMA ANFCPDHKAP MVLFLDRVYG IKDQTFLLHL
     LEVGFLPDLR ASASLDTVSL STAEAALALN RYICSAVLPL LTRCAPLFAG TEHCTSLIDS
     TLQTIYRLSK GRSLTKAQRD TIEECLLAIC NHLRPSMLQQ LLRRLVFDVP QLNEYCKMPL
     KLLTNHYEQC WKYYCLPSGW GSYGLAVEEE LHLTEKLFWG IFDSLSHKKY DPDLFRMALP
     CLSAIAGALP PDYLDTRITA TLEKQISVDA DGNFDPKPIN TMNFSLPEKL EYIVTKYAEH
     SHDKWACDKS QSGWKYGISL DENVKTHPLI RPFKTLTEKE KEIYRWPARE SLKTMLAVGW
     TVERTKEGEA LVQQRENEKL RSVSQANQGN SYSPAPLDLS NVVLSRELQG MVEVVAENYH
     NIWAKKKKLE LESKGGGSHP LLVPYDTLTA KEKFKDREKA QDLFKFLQVN GVIVSRGMKD
     MELDASSMEK RFAYKFLKKI LKYVDSAQEF IAHLEAIVSS GKTEKSPHDQ EIKFFAKVLL
     PLVDQYFTNH RLYFLSSPLK PLSSSGYASH KEKEMVASLF CKLAALVRHR ISLFGSDSTT
     MVSCLHILAQ TLDTRTVMKS GSELVKAGLR AFFENAAEDL EKTSENLKLG KFTHSRTQIK
     GVSQNINYTT VALLPILTSI FEHVTQHQFG MDLLLGDVQI SCYHILCSLY SLGTGKNIYV
     ERQRPALGEC LASLAAAIPV AFLEPTLNRY NLLSVFNTKT PRERSILGMP DTVEDMCPDI
     PQLEGLMKEI NDLAESGARY TEMPHVIEVI LPMLCNYLSY WWERGPENLP PSTGPCCTKV
     TSEHLSLILG NILKIINNNL GIDEASWMKR IAVYAQPIIS KARPDLLRSH FIPTLEKLKK
     KAVKTVQEEE QLKADGKGDT QEAELLILDE FAVLCRDLYA FYPMLIRYVD NNRSNWLKSP
     DADSDQLFRM VAEVFILWCK SHNFKREEQN FVIQNEINNL AFLTGDSKSK MSKVSPKSGG
     QDQERKKTKR RGDLYSIQTS LIVAALKKML PIGLNMCTPG DQELISLAKS RYGHRDTDEE
     VREHLRNNLH LQEKSDDPAV KWQLNLYKDV LKSEEPFNPE KTVERVQRIS AAVFHLEQVE
     QPLRSKKAVW HKLLSKQRKR AVVACFRMAP LYNLPRHRSI NLFLHGYQRF WIETEEYSFE
     EKLVQDLAKS PKVEEEEEEE TEKQPDPLHQ IILYFSRNAL TERSKLEDDP LYTSYSSMMA
     KSCQSGEDEE EDEDKEKTFE EKEMEKQKTL YQQARLHERG AAEMVLQMIS ASKGEMSPMV
     VETLKLGIAI LNGGNAGVQQ KMLDYLKEKK DAGFFQSLSG LMQSCSVLDL NAFERQNKAE
     GLGMVTEEGT LIVRERGEKV LQNDEFTRDL FRFLQLLCEG HNSDFQNFLR TQMGNTTTVN
     VIISTVDYLL RLQESISDFY WYYSGKDIID ESGQHNFSKA LAVTKQVFNS LTEYIQGPCI
     GNQQSLAHSR LWDAVVGFLH VFANMQMKLS QDSSQIELLK ELLDLLQDMV VMLLSLLEGN
     VVNGTIGKQM VDTLVESSTN VEMILKFFDM FLKLKDLTSS DTFKEYDPDG KGIISKKEFQ
     KAMEGQKQYT QSEIDFLLSC AEADENDMFN YVDFVDRFHE PAKDIGFNVA VLLTNLSEHM
     PNDSRLKCLL DPAESVLNYF EPYLGRIEIM GGAKKIERVY FEISESSRTQ WEKPQVKESK
     RQFIFDVVNE GGEQEKMELF VNFCEDTIFE MQLASQISES DSADRPEEEE EDEDSSYVLE
     IAGEEEEDGS LEPASAFAMA CASVKRNVAD FLKKATLKNL RKQYRNVKKM TAKELVKVFF
     SFFWMLFVGL FQLLFTILGG VFQILWSTVF GGGLVEGAKN IRVTKILGDM PDPTQFGIHD
     DTMEAERAEV MEPGITTELV HFIKGEKGDT EIMSDLFGLH PKKEGSLKHG PEVGLGDLSE
     IIGKDEPPTL ESTVQKKRKA QAAEMKAANE AEGKESEKAD MEDGEKEDKD KEEEQAEYLW
     TEVTKKKKRR CGQKVEKPEA FTANFFKGLE IYQTKLLHYL ARNFYNLRFL ALFVAFAINF
     ILLFYKVTEE PLEEETEDVA NLWNSFNDEE EEEAMVFFVL QESTGYMAPT LRALAIIHTI
     ISLVCVVGYY CLKVPLVVFK REKEIARKLE FDGLYITEQP SEDDIKGQWD RLVINTPSFP
     NNYWDKFVKR KVINKYGDLY GAERIAELLG LDKNALDFSP VEETKAEAAS LVSWLSSIDM
     KYHIWKLGVV FTDNSFLYLA WYTTMSVLGH YNNFFFAAHL LDIAMGFKTL RTILSSVTHN
     GKQLVLTVGL LAVVVYLYTV VAFNFFRKFY NKSEDDDEPD MKCDDMMTCY LFHMYVGVRA
     GGGIGDEIED PAGDPYEMYR IVFDITFFFF VIVILLAIIQ GLIIDAFGEL RDQQEQVRED
     METKCFICGI GNDYFDTTPH GFETHTLQEH NLANYLFFLM YLINKDETEH TGQESYVWKM
     YQERCWDFFP AGDCFRKQYE DQLG
//
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