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Database: UniProt
Entry: G1RII7_NOMLE
LinkDB: G1RII7_NOMLE
Original site: G1RII7_NOMLE 
ID   G1RII7_NOMLE            Unreviewed;      4794 AA.
AC   G1RII7;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   28-MAR-2018, entry version 47.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSNLEP00000013043};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSNLEP00000013043};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates
OS   leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hylobatidae; Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000013043};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000013043}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000013043}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; ADFV01073594; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01073595; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01073596; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01073597; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01073598; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01073599; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01073600; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01073601; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01073602; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01073603; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 61853.ENSNLEP00000013043; -.
DR   Ensembl; ENSNLET00000013682; ENSNLEP00000013043; ENSNLEG00000010690.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; G1RII7; -.
DR   OMA; HDECLTI; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000001073; Chromosome 6.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 3.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 9.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001073};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4111   4135       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4341   4361       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4409   4428       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4534   4552       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4595   4616       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4675   4698       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       95    150       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      157    202       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      210    264       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      270    328       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      338    395       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      542    753       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      957   1153       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1199   1411       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3847   3882       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      454    474       {ECO:0000256|SAM:Coils}.
FT   COILED     3160   3180       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4794 AA;  543965 MW;  F579E115D6DEE746 CRC64;
     MARCSEGGRL QLEDEVVLQC IATIHKEQRK FCLAAEGLGN RLCFLEPTSE AKYIPPDLCV
     CNFVLEQSLS VRALQEMLAN TGENGGEGAA QGGGHRTLLY GHAVLLRHSF SGMYLTCLTT
     SRSQTDKLAF DVGLREHATG EACWWTIHPA SKQRSEGEKV RIGDDLILVS VFSERYLHLS
     VSNGNIQVDA SFMQTLWNVH PTCSGSSIEE GYLLGGHVVR LFHGHDECLT IPSTDQNDSQ
     HRRIFYEAGG AGTRARSLWR VEPLRISWSG SNIRWGQAFR LRHLTTGHYL ALTEDQGLIL
     QDRAKSDTKS TAFSFRASKE LKEKLDSSHK RDIEGMGVPE IKYGDSVCFV QHIASGLWVT
     YKAQDAKTSR LGPLKRKVIL HQEGHMDDGL TLQRCQREES QAARIIRNTT ALFSQFVSGN
     NRTAAPITLP IEEVLQTLQD LIAYFQPPEE EMRHEDKQNK LRSLKNRQNL FKEECLQTLV
     FSALIRGNRN NCAQFSNNLD WLISKLDRLE SSSGILEVLH CILTESPEAL NLIAEGHIKS
     IISLLDKHGR NHKVLDILCS LCLCNGIAVR ANQNLICDNL LPRRNLLLQT RLINDVTSIR
     PNIFLGVAEG SAQYKKWYFE LIIDQVDPFL TAEPTHLRVG WASSSGYAPY PGGGEGWGGN
     GVGDDLYSYG FDGLHLWSGR IPRAVASINQ HLLRSDDVVS CCLDLGVPSI SFRINGQPVQ
     GMFENFNTDG LFFPVMSFSA GVKVRFLMGG RHGEFKFLPP SGYAPCYEAL LPKEKMRLEP
     VKEYKRDADG VRDLLGTTQF LSQASFIPCP IDTSQVVLPP HLEKIRDRLA ENIHELWGMN
     KIELGWTFGK IRDDNKRQHP CLVEFSKLPE TEKNYNLQMS TETLKVGPVT VAFFAQHSYH
     VYMMSNGYKP APLDLSDVKL LPPQEILVDK LAENAHNVWA KDRIKQGWTY GIQQDLKNKR
     NPRLVPYALL DERTKKSNRD SLREAVRTFV GYGYNIEPSD QELADSAVEK VSIDKIRFFR
     VERSYAVRSG KWYFEFEVVT GGDMRVGWAR PGCRPDVELG ADDQAFVFEG NRGQRWHQGS
     GYFGRTWQPG DVVGCMINLD DASMIFTLNG ELLITNKGSE LAFADYEIEN GFVPICCLGL
     SQIGRMNLGT DASTFKFYTM CGLQEGFEPF AVNMNRDVAM WFSKRLPTFV NVPKDHPHIE
     VMRIDGTMDS PPCLKVTHKT FGTQNSNADM IYCRLSMPVE CHSSFSHSPC LDSEAFQKRK
     QMQEILSHTT TQCYYAIRIF AGQDPSCVWV GWVTPDYHLY SEKFDLNKNC TVTVTLGDER
     GRVHESVKRS NCYMVWGGDI VASSQRSNRS NVDLEIGCLV DLAMGMLSFS ANGKELGTCY
     QVEPNTKVFP AVFLQPTSTS LFQFELGKLK NAMPLSAAIF KSEEKNPCPP RLDVQTIQPV
     LWSRMPNSFL KVETERVSER HGWVVQCLEP LQMMALHIPE ENRCVDILEL CEQEDLMRFH
     YHTLRLYSAV CALGNSRVAY ALCSHVDLSQ LFYAIDNKYL PGLLRSGFYD LLISIHLANA
     KERKLMMKNE YIIPITSTTR NIRLFPDESK RHGLPGVGLR TCLKPGFRFS TPCFVVTGED
     HQKQSPEIPL ESLRTKALSM LTEAVQCSGA HIRDPVGGSV EFQFVPVLKL IGTLLVMGVF
     DDDDVRQILL LIDPSVFGEH SAGTEEGAEK EDVSQVEEKA VEAGEKAGKE APVKGLLQTR
     LPESVKLQMC ELLSYLCDCE LQHRVEAIVA FGDIYVSKLQ ANQKFRYNEL MQALNMSAAL
     TARKTKEFRS PPQEQINMLL NFQLGENCPC PEEIREELYD FHEDLLLHCG VPLEEEEEEE
     EDTSWTGKLC ALVYKIKGPP KPEKEQPTEE EERCPTTLKQ LISQTMICWA QEDQIQDSEL
     VRMMFNLLRR QYDSIGELLQ ALRKTYTISH TSVSDTINLL AALGQIRSLL SVRMGKEEEL
     LMINGLGDIM NNKVFYQHPN LMRVLGMHET VMEVMVNVLG TEKSQIAFPK MVASCCRFLC
     YFCRISRQNQ KAMFEHLSYL LENSSVGLAS PSMRGSTPLD VAASSVMDNN ELALSLEEPD
     LEKVVTYLAG CGLQSCPMLL AKGYPDVSWN PIEGERYLSF LRFAVFVNSE SVEENASVVV
     KLLIRRPECF GPALRGEGGN GLLAAMQGAI KISENPALDL PSQGYKREVT EDDEEEEEIV
     HMGNAIMSFY SALIDLLGRC APEMHLIQTG KGEAIRIRSI LRSLVPTEDL VGIISIPLKL
     PSLNKDGSVS EPDMAANFCP DHKAPMVLFL DRVYGIKDQT FLLHLLEVGF LPDLRASASL
     DTVSLSTAEA ALALNRYICS AVLPLLTRCA PLFAGTEHCT SLIDSTLQTI YRLSKGRSLT
     KAQRDTIEEC LLAICNHLRP SMLQQLLRRL VFDVPQLNEY CKMPLKLLTN HYEQCWKYYC
     LPSGWGSYGL AVEEELHLTE KLFWGIFDSL SHKKYDPDLF RMALPCLSAI AGALPPDYLD
     TRITATLEKQ ISVDADGNFD PKPINTMNFS LPEKLEYIVT KYAEHSHDKW ACDKSQSGWK
     YGISLDENVK THPLIRPFKT LTEKEKEIYR WPARESLKTM LAVGWTVERT KEGEALVQQR
     ENEKLRSVSQ ANQGNSYSPA PLDLSNVVLS RELQGMVEVV AENYHNIWAK KKKLELESKG
     GGSHPLLVPY DTLTAKEKFK DREKAQDLFK FLQVNGVIVS RGMKDMELDA SSMEKRFAYK
     FLKKILKYVD SAQEFIAHLE AIVSSGKTEK SPHDQEIKFF AKVLLPLVDQ YFTNHRLYFL
     SSPLKPLSSS GYASHKEKEM VASLFCKLAA LVRHRISLFG SDSTTMVSCL HILAQTLDTR
     TVMKSGSELV KAGLRAFFEN AAEDLEKTSE NLKLGKFTHS RTQIKGVSQN INYTTVALLP
     ILTSIFEHVT QHQFGMDLLL GDVQISCYHI LCSLYSLGTG KNIYVERQRP ALGECLASLA
     AAIPVAFLEP TLNRYNLLSV FNTKTPRERS ILGMPDTVED MCPDIPQLEG LMKEINDLAE
     SGARYTEMPH VIEVILPMLC NYLSYWWERG PENLPPSTGP CCTKVTSEHL SLILGNILKI
     INNNLGIDEA SWMKRIAVYA QPIISKARPD LLRSHFIPTL EKLKKKAVKT VQEEEQLKAD
     GKGDTQEAEL LILDEFAVLC RDLYAFYPML IRYVDNNRSN WLKSPDADSD QLFRMVAEVF
     ILWCKSHNFK REEQNFVIQN EINNLAFLTG DSKSKMSKSG GQDQERKKTK RRGDLYSIQT
     SLIVAALKKM LPIGLNMCTP GDQELISLAK SRYGHRDTDE EVREHLRNNL HLQEKSDDPA
     VKWQLNLYKD VLKSEEPFNP EKTVERVQRI SAAVFHLEQV EQPLRSKKAV WHKLLSKQRK
     RAVVACFRMA PLYNLPRHRS INLFLHGYQR FWIETEEYSF EEKLVQDLAK SPKVEEEEEE
     ETEKQPDPLH QIILYFSRNA LTERSKLEDD PLYTSYSSMM AKSCQSGEDE EEDEDKEKTF
     EEKEMEKQKT LYQQARLHER GAAEMVLQMI SASKGEMSPM VVETLKLGIA ILNGGNAGVQ
     QKMLDYLKEK KDAGFFQSLS GLMQSCSVLD LNAFERQNKA EGLGMVTEEG TLIVRERGKF
     QFLNDEFTRD LFRFLQLLCE GHNSDFQNFL RTQMGNTTTV NVIISTVDYL LRLQESISDF
     YWYYSGKDII DESGQHNFSK ALAVTKQVFN SLTEYIQGPC IGNQQSLAHS RLWDAVVGFL
     HVFANMQMKL SQSSKNSYLT SDMIAWVYLY IWNVVNGTIG KQMVDTLVES STNVEMILKF
     FDMFLKLKDL TSSDTFKEYD PDGKGIISKK EFQKAMEGQK QYTQSEIDFL LSCAEADEND
     MFNYVDFVDR FHEPAKDIGF NVAVLLTNLS EHMPNDSRLK CLLDPAESVL NYFEPYLGRI
     EIMGGAKKIE RVYFEISESS RTQWEKPQVK ESKRQFIFDV VNEGGEQEKM ELFVNFCEDT
     IFEMQLASQI SESDSADRPE EEEEDEDSSY VLEIAGEEEE DGSLEPASAF AMACASVKRN
     VADFLKKATL KNLRKQYRNV KKMTAKELVK VFFSFFWMLF VGLFQLLFTI LGGVFQILWS
     TVFGGGLVEG AKNIRVTKIL GDMPDPTQFG IHDDTMEAER AEVMEPGITT ELVHFIKGEK
     GDTEIMSDLF GLHPKKEGSL KHGPEVGLGD LSEIIGKDEP PTLESTVQKK RKAQAAEMKA
     ANEAEGKESE KADINYSNCY EKEDKDKEEE QAEYLWTEVT KKKKRRCGQK VEKPEAFTAN
     FFKGLEIYQT KLLHYLARNF YNLRFLALFV AFAINFILLF YKVTEEPLEE ETEDVANLWN
     SFNDEEEEEA MVFFVLQEST GYMAPTLRAL AIIHTIISLV CVVGYYCLKV PLVVFKREKE
     IARKLEFDGL YITEQPSEDD IKGQWDRLVI NTPSPCHPLF QVINKYGDLY GAERIAELLG
     LDKNALDFSP VEETKAEAAS LVSWLSSIDM KYHIWKLGVV FTDNSFLYLA WYTTMSVLGH
     YNNFFFAAHL LDIAMGFKTL RTILSSVTHN GKQLVLTVGL LAVVVYLYTV VAFNFFRKFY
     NKSEDDDEPD MKCDDMMTCY LFHMYVGVRA GGGIGDEIED PAGDPYEMYR IVFDITFFFF
     VIVILLAIIQ GLIIDAFGEL RDQQEQVRED METKCFICGI GNDYFDTTPH GFETHTLQEH
     NLANYLFFLM YLINKDETEH TGQESYVWKM YQERCWDFFP AGDCFRKQYE DQLG
//
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