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Database: UniProt
Entry: G1RKX4_NOMLE
LinkDB: G1RKX4_NOMLE
Original site: G1RKX4_NOMLE 
ID   G1RKX4_NOMLE            Unreviewed;      1017 AA.
AC   G1RKX4;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   25-OCT-2017, entry version 45.
DE   SubName: Full=Potassium voltage-gated channel subfamily H member 4 {ECO:0000313|Ensembl:ENSNLEP00000013881};
GN   Name=KCNH4 {ECO:0000313|Ensembl:ENSNLEP00000013881};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates
OS   leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hylobatidae; Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000013881, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000013881}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000013881}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSNLEP00000013881}.
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DR   EMBL; ADFV01118230; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01118231; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01118232; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003279506.1; XM_003279458.1.
DR   STRING; 61853.ENSNLEP00000013881; -.
DR   Ensembl; ENSNLET00000014563; ENSNLEP00000013881; ENSNLEG00000011421.
DR   GeneID; 100597624; -.
DR   KEGG; nle:100597624; -.
DR   CTD; 23415; -.
DR   eggNOG; KOG0498; Eukaryota.
DR   eggNOG; ENOG410XPSE; LUCA.
DR   GeneTree; ENSGT00900000140833; -.
DR   InParanoid; G1RKX4; -.
DR   KO; K04907; -.
DR   OMA; VPKAVWD; -.
DR   OrthoDB; EOG091G0OXR; -.
DR   TreeFam; TF313130; -.
DR   Proteomes; UP000001073; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR003950; K_chnl_volt-dep_ELK.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF13426; PAS_9; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   PRINTS; PR01465; ELKCHANNEL.
DR   SMART; SM00100; cNMP; 1.
DR   SMART; SM00086; PAC; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   SUPFAM; SSF55785; SSF55785; 1.
DR   TIGRFAMs; TIGR00229; sensory_box; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS50113; PAC; 1.
DR   PROSITE; PS50112; PAS; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001073};
KW   Ion channel {ECO:0000256|SAAS:SAAS00904115};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00903208};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00904256};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00903350};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00903851}.
FT   TRANSMEM    228    248       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    268    288       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    323    345       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    357    383       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    425    447       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    454    478       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       14     90       PAS. {ECO:0000259|PROSITE:PS50112}.
FT   DOMAIN       93    145       PAC. {ECO:0000259|PROSITE:PS50113}.
FT   DOMAIN      556    620       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
FT   COILED      873    907       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1017 AA;  111609 MW;  3E293D31FA9904F0 CRC64;
     MPVMKGLLAP QNTFLDTIAT RFDGTHSNFL LANAQGTRGF PIVYCSDGFC ELTGYGRTEV
     MQKTCSCRFL YGPETSEPAL QRLHKALEGH QEHRAEICFY RKDGSAFWCL LDMMPIKNEM
     GEVVLFLFSF KDITQSGSPG FGPQGGRVDS NPENSLGRRG ATWKFRSARR RSRTVLRRLT
     GHFGRRGQGG MKANNNVFEP KPSVPEYKVA SVGGSRCLLL HYSVPKAIWD GLILLATFYV
     AVTVPYNVCF SGDDDTPITS RHTLVSDIAV EMLFILDIIL NFRTTYVSQS GQVISAPRSI
     GLHYLATWFF VDLIAALPFD LLYVFNITVT SLVHLLKTVR LLRLLRLLQK LERYSQCSAV
     VLTLLMSVFA LLAHWMACIW YVIGRREMEA NDPLLWDIGW LHELGKRLEV PYVNGSVGGP
     SRRSAYIAAL YFTLSSLTSV GFGNVCANTD AEKIFSICTM LIGALMHAVV FGNVTAIIQR
     MYSRRSLYHS RMKDLKDFIS VHRLPRPLKQ RMLEYFQTTW AVNSGIDANE LLRDFPDELR
     ADIAMHLNRE ILQLPLFGAA SRGCLRALSL HIKTSFCAPG EYLLRRGDAL QAHYYVCSGS
     LEVLRDNMVL AILGKGDLIG ADIPEPGQEP GLGADPSFVL KTSADVKALT YCGLQQLSSP
     GLAEVLRLYP EYGAAFRAGL PRDLTFNLRQ GSDTSGLSRF SRSPRLSQPR SESLGSSSDK
     TLPSITEAES GTETGGGPRP RRPLLLPNLS PARPRGSLVS LLGEELPPFS ALVSSPSLSP
     SLSPALAGQG HSASPHGPPR CSAAWKPPQL LIPPLGTFGP PDLSPRIVDG IEDSGSTAEA
     PSFRFSRRPE LPRPRSQAPP TGTRPSPELA SEAEEVKEKV CRLNQEISRL NQEVSQLSRE
     LRHIMGLLQA RLGPPGHPAG SAWTPDPPCP QLRPPCLSPC ASRPPPSLQD TTLAEVHCPA
     SVGTMETGTA LLDLRPSILP PYPSEPDPLG PSPVPEASPP TPSLLRHSFQ SRSDTFH
//
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