ID G1RLC3_NOMLE Unreviewed; 709 AA.
AC G1RLC3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Kirre like nephrin family adhesion molecule 2 {ECO:0000313|Ensembl:ENSNLEP00000014031.2};
GN Name=KIRREL2 {ECO:0000313|Ensembl:ENSNLEP00000014031.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000014031.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000014031.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000014031.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC {ECO:0000256|ARBA:ARBA00008637}.
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DR EMBL; ADFV01122174; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1RLC3; -.
DR Ensembl; ENSNLET00000014720.2; ENSNLEP00000014031.2; ENSNLEG00000011490.2.
DR eggNOG; KOG3510; Eukaryota.
DR GeneTree; ENSGT00940000160603; -.
DR HOGENOM; CLU_013520_1_1_1; -.
DR TreeFam; TF327139; -.
DR Proteomes; UP000001073; Chromosome 10.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR11640:SF51; KIN OF IRRE-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR11640; NEPHRIN; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 1.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..709
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014111788"
FT TRANSMEM 512..535
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 25..119
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 124..223
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 228..308
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 313..395
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 399..502
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 546..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..561
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..597
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 709 AA; 75184 MW; 2EEAB6A170CB0003 CRC64;
MGRGMRVPAL LVLLFCFRGS AGPSPHFLQQ PEDLVVLLGE EARLPCALGA YWGLVQWTKS
GLALGGQRDL PGWSRYWISG NAANGQHDLH IRPVELEDEA SYECQATQAG LRSRPAQLHV
LVAPEAPQVL GGPSVSLVAG VPANLTCRSR GDARPTPELL WFRDGVRLDG TTFHQTLLKE
GTPGSVENTL TLTPFSHDDG ATLVCRARSQ ALPAGRDTAI TLSLQYPPEV TLSASPHTVQ
EGEKVIFLCQ ATAQPPVTGY RWAKGGSPVL GARGPRLEVV ADASFLTEPV SCEVSNAVGS
ANRSTALDVL FGPILQAKPE PVSVDVGEDA SFSCAWRGNP LPRVTWTRRG GAQVLGSGAT
LRLPSVRPED AGDYVCRAEP GLSGLGGGAA EARLTVNAPP VVTALHSAPA FLRGPARLQC
LVFASPAPDA VVWSWDEGFL EVGSQGRFLV ETFPAPESRG GQNPGLISVL HISGTQESDF
SRSFNCSARN RLGEGGARAS LGRRDLLPTV RIVAGVAAAT TTLLMVITGV ALCCWRHSKA
SASFSEQKNL MRIPGSSDGS SSRGPEEEET GSREERGPVV HTDHSDLVLE EEGTLDTRDP
TNGYYKVRGV SVSLSLGEAP GGGLFLPPPS PLGPPGTPTF YDFNPHLGMV PPCRLYRAGA
GYLTTPHPRA FTSYIKPTSF GPPDLAPGTP HFPYAAFHTP SHPRLQTHV
//
