ID G1RLZ7_NOMLE Unreviewed; 578 AA.
AC G1RLZ7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=RNA methyltransferase {ECO:0000256|RuleBase:RU367087};
DE EC=2.1.1.- {ECO:0000256|RuleBase:RU367087};
GN Name=MEPCE {ECO:0000313|Ensembl:ENSNLEP00000014261.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000014261.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000014261.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000014261.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC {ECO:0000256|RuleBase:RU367087}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ADFV01105317; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01105318; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01105319; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1RLZ7; -.
DR STRING; 61853.ENSNLEP00000014261; -.
DR Ensembl; ENSNLET00000014966.2; ENSNLEP00000014261.2; ENSNLEG00000011734.2.
DR eggNOG; KOG2899; Eukaryota.
DR GeneTree; ENSGT00940000153993; -.
DR HOGENOM; CLU_004729_3_3_1; -.
DR InParanoid; G1RLZ7; -.
DR OMA; KGQNRDA; -.
DR TreeFam; TF324061; -.
DR Proteomes; UP000001073; Chromosome 17.
DR GO; GO:0120259; C:7SK snRNP; IEA:Ensembl.
DR GO; GO:0097322; F:7SK snRNA binding; IEA:Ensembl.
DR GO; GO:1990276; F:RNA 5'-methyltransferase activity; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:1900087; P:positive regulation of G1/S transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:1904871; P:positive regulation of protein localization to Cajal body; IEA:Ensembl.
DR GO; GO:1905382; P:positive regulation of snRNA transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0001510; P:RNA methylation; IEA:Ensembl.
DR GO; GO:0040031; P:snRNA modification; IEA:Ensembl.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR039772; Bin3-like.
DR InterPro; IPR024160; BIN3_SAM-bd_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR12315:SF0; 7SK SNRNA METHYLPHOSPHATE CAPPING ENZYME; 1.
DR PANTHER; PTHR12315; BICOID-INTERACTING PROTEIN RELATED; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51515; BIN3_SAM; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|RuleBase:RU367087};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW S-adenosyl-L-methionine {ECO:0000256|PROSITE-ProRule:PRU00848,
KW ECO:0000256|RuleBase:RU367087};
KW Transferase {ECO:0000256|RuleBase:RU367087}.
FT DOMAIN 398..578
FT /note="Bin3-type SAM"
FT /evidence="ECO:0000259|PROSITE:PS51515"
FT REGION 1..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..95
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..237
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..372
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 578 AA; 61152 MW; 36F9B8D07F235E50 CRC64;
MIEMAAEKEP FLVPAPPPPL KDESGGGGGP TVPPHQEAAS GELRGGTERG PGPCAPSAGS
PATGVGRESP GAAATSPGGP QAQQHRGSGP QAQSHGEARL SDPPGRAAPP DVGEERRGGG
GTELGPPAPP RPRNGYQPHR PPGGGGGKRR NSCNVGGGGG GFKHPAFKRR RRVNSDCDST
PKSSPLPAKG RDPVEILIPK DITDPLSLNT CTDEGHVVLA SPLKTGRKRH RHRGQHHQQQ
QAAGGSESHP VPPTAPLTPS LHGEGASQQP RHRGQNRDAP QPYELNTAIN CRDEVVSPLP
SALQGPSGSL SAPPAASVMS APPSSSSRHR KRRRTSSKSE AGARGGGQGP KEKGRGSWGG
RHHHHHPLPA AGFKKQQRKF QYGNYCKYYG YRNPSCEDGR LRVLKPEWFR GRDVLDLGCN
VGHLTLSIAC KWGPSRMVGL DIDSRLIHSA RQNIRHYLSE ELRLPPQTLE GDPGAEGEEG
TTTVRKRSCF PASLTASRGP IAAPQVPLDG ADTSVFPNNV VFVTVRGSRE PLLGVSSLIT
WKGGVSTLGY ELVATPHNTS KGFQRPVYLF HKARSPSH
//
