ID G1RNY5_NOMLE Unreviewed; 4039 AA.
AC G1RNY5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Dynein axonemal heavy chain 3 {ECO:0000313|Ensembl:ENSNLEP00000014949.2};
GN Name=DNAH3 {ECO:0000313|Ensembl:ENSNLEP00000014949.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000014949.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000014949.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000014949.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; ADFV01197397; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01197398; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01197399; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01197400; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01197401; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01197402; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01197403; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01197404; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 61853.ENSNLEP00000014949; -.
DR Ensembl; ENSNLET00000015695.2; ENSNLEP00000014949.2; ENSNLEG00000012272.2.
DR eggNOG; KOG3595; Eukaryota.
DR GeneTree; ENSGT00940000154959; -.
DR HOGENOM; CLU_000038_0_0_1; -.
DR InParanoid; G1RNY5; -.
DR OMA; FFQSCAK; -.
DR TreeFam; TF316836; -.
DR Proteomes; UP000001073; Chromosome 2.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46961:SF8; DYNEIN AXONEMAL HEAVY CHAIN 3; 1.
DR PANTHER; PTHR46961; DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 1344..1483
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1989..2136
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 118..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 738..775
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2828..2893
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 118..135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4039 AA; 462232 MW; 6F71241BC9C40265 CRC64;
MGATRRLELT LAAPPHLGPI AKSDSIHHMS HSQGQPELPP LPASANEEPS GLYQTVMSHS
FYPPLMQHTS WTLAAPFKEQ HHHRGPSDSI ANNYSLMAQD LKLKDLLKVY QPATINVPRD
RTSQGLPSSA NKSSSEPMRK KTKFSSRNKE DSIGFKTSIF SPMKKEVKTS LTFPGSRPMS
PEQQLDVMLQ QEMEMESKEK KPSESDLERY YYYLTNGIRK DMIAPEEGEV MVRISKLISN
TLLTSPFLEP LMVVLVQEKE NDYYSSLMKS IVDYILMDPM ERKRLFIESI PRLFPQRVIR
APVPCHSVYR SAKKWNEEHL HTVNPMMLRL KELWFAEFRD LRFVRTAEIL AGKLPLQPQE
FGDVIQKHCL EAHQTLLNKW IPTCAQLFTS RKEHWIHFAP KSNYDSCRNI EEYFASVASF
MSLQLRELVI KSLEDLVSLF MIHKDGNDFK EPYQEMKFFI PQLIMIKLEV SEPIIVFNPS
FDGCWELIRD SFLEIIKNSN GIPKCIRGGF AFGQTFKVFQ KNQVGPRKYL NVYKKYDDLL
DNTAEENITA FLKENHDIDD FVTKINAIKK RRNEIASMHI TVPLAMFCLD AMALNYDLCE
RAQNLKDHLI QFQVDVNRDT NTSICNQYSH IADKVSEVPA NTKELVFLIE FLKKSSDVTV
FKLRRQLRDA SERLEFLMDY ADLPYQIEDI FENSRNLLLH KRDQAEMDLI KRCSEFESRL
EGYHRELEGF RKREVMTTEE MKHNVEKLNE LSKNLNQALA EFELINKEEE LLEKEKSTYP
LLQAMLTNKV PYEQLWSTAY EFSTKSEEWM NGPLFLLNAE QIAEEIGNMW RTTYKLIKTL
SDVPAPRRLA ENVKIKIDKF KQYIPILSIS CNPGMKDRHW QQISEIVGHE IKPTETTCLS
NMLEFGFGKF VEKLEPIGAA ASKEYSLEKN LDRMKLDWVN VTFSFIKYRD TDTSILCAID
DIQMLLDDHV IKTQTMCGSP FIKSIEAECQ KWEEKLIRIQ DNLDAWLKCQ ATWLYLEPIF
SSEDIIAQMP EEGRKFGIVD SYWKSLMSQA VKDNRVLVAA DQPRMAEKLQ EANFLLEDIQ
KGLNDYLEKK RLFFPRFFFL SNDELLEILS ETKDPLRVQP HLKKCFEGIA KLEFTDNLEI
VGMISSEKET VPFIQKIYPA NAKGMVEKWL QQVEQMMLAS MREVIGLGIE AYVKVPRNHW
VLQWPGQVVI CVSSIFWTQE VSQALGENTL PDFLKKSNDQ IAQIVQLVRG KLSSGARLTL
GALTVIDVHA RDVVAKLSED RVSDLNDFQW ISQLRYYWVA KDVQVQIIST EALYGYEYLG
NSPRLVITPL TDRCYRTLMG ALKLNLGGAP EGPAGTGKTE TTKDLAKALA KQCVVFNCSD
GLDYKAMGKF FKGLAQAGAW ACFDEFNRIE VEVLSVVAQQ ILSIQQAIIR KLKTFIFEGT
ELSLNPTCAV FITMNPGYAG RAELPDNLKA LFRTVAMMVP DYALIGEISL YSMGFLDSRS
LAQKIVATYR LCSEQLSSQH HYDYGMRAVK SVLTAAGNLK LKYPEENESV LLLRALLDVN
LAKFLAQDVP LFQGIISDLF PGVVLPKPDY EVFLKVLNDN IKKMKLQPVP WFIGKIIQIY
EMMLVRHGYM IVGDPMGGKT SAYKVLAAAL GDLHAANQME EFAVEYKIIN PKAITMGQLY
GCFDQVSHEW TDGVLANAFR EQASSLSDDR KWIIFDGPVD AVWIENMNTV LDDNKKLCLM
SGEIIQMNSK MSLIFEPADL EQASPATVSR CGMIYMEPHQ LGWKPLKDSY MDTLPSSLTK
EHKELVNDMF MWLVQPCLEF GRLHCKFVVQ TSPVHLAFSM MRLYSSLLDE IRAVEEEEME
LGEGLSSQQI FLWLQGLFLF SLVWTVAGTI NADSRKKFDV FFRNLIMGMD DNYPRPKSVK
LTKNNIFPER GSIYDFYFIK QASGRWETWT QYITKEEEKI PAGAKVSELI IPTMETARQS
FFLKTYLDHE IPTLFVGPTG TGKSAITNNF LLHLPKNTYL PNCISFSART SANQTQDIIM
SKLDRRRKGL FGPPIGKKAV VFVDDLNMPA KEVYGAQPAI ELLRQWIDHG YWFDKKDTTR
LDIVDMLLVT AMGPPGGGRN DITGRFTRHL NIVSISAFED DILTKIFSSI VDWHFGKGFD
VMFLRYGKML VQATKTIYRD AVENFLPTPS KSHYVFNLRD FSRVIQGVLL CPHTHLQDVE
KCIRLWIHEV YRVFYDRLID KEDRQVFFNM VKETTSNCFK QTIEKVLIHL SPTGKIVDDN
IRSLFFGDYF KPDSDQKIYD EITDLKQLTV VMEHYLEEFN NISKAPMSLV MFRFAIEHIS
RICRVLKQDK GHLLLVGIGG SGRQSATKLS TFMNAYELYQ IEITKNYTGN DWREDLKKIM
LQVGVATKST VFLFADNQIK DESFVEDINM LLNTGDVPNI FPADEKADIV EKMQTAARTQ
GEKVEVTPLS MYNFFIERVI NKISFSLAMS PIGDAFRNRL RMFPSLINCC TIDWFQSWPT
DALELVANKF LEDVELDDNI RIEVVSMCKY FQESVKKLSF DYYNKLRRHN YVTPTSYLEL
ILTFKTLLNS KRQEVAMMRN RYLTGLQKLD FAASQVAVMQ RELTALQPQL ILTSEETAKM
MVKIEVETRE ADAKKLLVQA DEKEANAAAA IAQGIKNECE GDLAEAMPAL EAALAALDTL
NPADISLVKS MQNPPGPVKL VMESICVMKG MKPERKPDPG GSGKMIEDYW GVSKKILGDL
KFLESLKTYD KDNIPPLTMK RIRERFINHP EFQPAVIKNV SSACEGLCKW VRAMEVYDRV
AKVVAPKRER LREAEGKLDA QMQKLNQKRA ELKLVVDRLQ ALNDDFEEMN TKKKDLEENI
EICSQKLVRA EKLISGLGGE KDRWTEAAQQ LGIRYTNLTG DVLLSSGTVA YLGAFTVDYR
VQCQNQWLAE CKDKVIPGSS DFSLSHTLGD PIKIRAWQIA GLPVDSFSID NGIIVSNSRR
WALMIDPQGQ ANKWIKNMEK ANKLAVIKFS DSNYMRMLEN ALQLGTPVLI ENIGEELDAS
IEPILLKATF KQQGVEYMRL GENIIEYSRD FKLYITTRLR NPHYLPEVAV KVCLLNFMIT
PLGLQDQLLG IVAAKEKPEL EEKKNQLIVE SAENKKHLKE IEDKILEVLS MSKGNILEDE
TAIKVLSSSK VLSEEISEKQ KVASMTETQI DETRMGYKPV AVHSATIFFC ISDLANIEPM
YQYSLTWFIN LYMHSLAHST KSEELNLRIK YIIDHFTLSI YNNVCRSLFE KDKLLFSLLL
TIGIMKQKKE ITEEVWYFLL TGGIALDNPY PNPAPQWLSE KAWAEIVRAS ALPKLHGLME
HLEQNLHEWK LIYDSAWPHE EQLPGSWKFS QGLEKMVILR CLRPDKMVPA VREFIAEHMG
KLYIEATTFD LQGSYNDSSC CVPLIFVLSP SADPMAGLLK FADDRGMGGT RTQTISLGQG
QGPIAAKMIN NAIKDGTWVV LQNCHLATSW MPTLEKICEE VIVPESTNAR FRLWLTSYPS
EKFPVSILQN GIKMTNEPPK GLRANLLRSY LNDPVSDPVF FQSCAKAVMW QKMLFGLCFF
HAIVQERRNF GPLGWNIPYE FNESDLRISM WQIQMFLNDY KVVPFDALTY LTGECNYGGR
VTDDKDRRLL LSLLSMFYCK EIEEDYYSLA PGDTYYIPPH GSYQSYIDYL RNLPVTAHPE
VFGLHENADI TKDNQETNQL FEGVLLTLPR QSGGSGKSPQ EVVEELAQDI LSKLPKDFDL
EEVMKLYPMV YEESMNTVLR QELIRFNRLT KVVRRSLIDL GRAIRGQVLM SSELEEVFNS
MLVGKVPAMW AAKSYPSLKP LGGYVADLLA RLTFFQEWID KGPPAVFWIS GFYFTQSFLT
GVSQNYARKY TIPIDHIGFE FEVTPQETVM ENNPKDGAYI KGLFLEGARW DRKTMQIGES
LPKILYDPLP IIWLKPGESA MFLHQDIYVC PVYKTSARRG TLSTTGHSTN YVLSIELPTD
MPQKHWINRG VASLCQLDN
//
