ID G1RSR9_NOMLE Unreviewed; 203 AA.
AC G1RSR9;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 3.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Insulin-like domain-containing protein {ECO:0000259|SMART:SM00078};
GN Name=INS {ECO:0000313|Ensembl:ENSNLEP00000016293.3};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000016293.3, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000016293.3, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000016293.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01129730; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01129731; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01129732; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01129733; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1RSR9; -.
DR STRING; 61853.ENSNLEP00000016293; -.
DR Ensembl; ENSNLET00000017127.2; ENSNLEP00000016293.3; ENSNLEG00000013456.3.
DR eggNOG; ENOG502T8I0; Eukaryota.
DR GeneTree; ENSGT00390000015440; -.
DR HOGENOM; CLU_112503_0_0_1; -.
DR InParanoid; G1RSR9; -.
DR OrthoDB; 4213741at2759; -.
DR Proteomes; UP000001073; Chromosome 4.
DR GO; GO:0005615; C:extracellular space; ISS:AgBase.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:0005159; F:insulin-like growth factor receptor binding; ISS:AgBase.
DR GO; GO:1903576; P:response to L-arginine; ISS:AgBase.
DR CDD; cd04367; IlGF_insulin_like; 1.
DR Gene3D; 1.10.100.10; Insulin-like; 1.
DR InterPro; IPR004825; Insulin.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR036438; Insulin-like_sf.
DR PANTHER; PTHR11454:SF32; INSULIN, ISOFORM 2; 1.
DR PANTHER; PTHR11454; INSULIN/INSULIN GROWTH FACTOR; 1.
DR Pfam; PF00049; Insulin; 1.
DR PRINTS; PR00277; INSULIN.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..203
FT /note="Insulin-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014171564"
FT DOMAIN 28..123
FT /note="Insulin-like"
FT /evidence="ECO:0000259|SMART:SM00078"
FT REGION 59..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 148..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..78
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..173
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 203 AA; 21793 MW; DC8D644733FEC56E CRC64;
MALWMRLLPL LALLALWGPD PAPAFVNQHL CGSHLVEALY LVCGERGFFY TPKTRREAED
PQASALSPSS STSTWPEGLD ATARAPPALV ATANFGQVGG SSSRQFRQRA LGTSDSPVLF
IHCPGAAGTA RGLEYRGRRV TTELVWEEVD SSPQPQGSES LPAQPPAQPA PQPEPQQARA
AGEPSPEVSC CGLWPRRPQR SQN
//
