ID G1RSY4_NOMLE Unreviewed; 1834 AA.
AC G1RSY4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Plexin B3 {ECO:0000313|Ensembl:ENSNLEP00000016358.2};
GN Name=PLXNB3 {ECO:0000313|Ensembl:ENSNLEP00000016358.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000016358.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000016358.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000016358.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR EMBL; ADFV01117758; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01117759; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01117760; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSNLET00000017197.2; ENSNLEP00000016358.2; ENSNLEG00000013475.3.
DR eggNOG; KOG3610; Eukaryota.
DR GeneTree; ENSGT01020000230394; -.
DR HOGENOM; CLU_001436_1_1_1; -.
DR Proteomes; UP000001073; Chromosome X.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR CDD; cd01180; IPT_plexin_repeat1; 1.
DR CDD; cd01179; IPT_plexin_repeat2; 1.
DR CDD; cd11277; Sema_plexin_B3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR041362; TIG2_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF33; PLEXIN-B3; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 3.
DR Pfam; PF18020; TIG_2; 1.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 3.
DR SMART; SM00423; PSI; 3.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..43
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 44..1834
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014184137"
FT DOMAIN 32..472
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT REGION 1548..1596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1548..1566
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1834 AA; 197221 MW; 20531947AEF3DBA4 CRC64;
MCHATQETPL LHHFMVSPRD GSLASFGLCL LLLLLSPPPK TKTGTHRFSA PNTTFNHLAL
APDRGTLYVG AVNRLFQLSP ELQVEGVAVT GPVIDSPDCV PFRDPAEYPQ AQLTDNANQL
LLVSSRAQEL VACGQVRQGV CETRRLGDVA EVLYQAEDPG DGQFVAANTP GVATVGLVVP
LPGRDLLLVA RGLAGKLSAG VPPLAIRQLA GSQPFSSEGL GRLVVGDFSD YNNSYVGAFA
DARSAYFVFR RRGARAQAEY RSYVARVCLG DTNLYSYVEV PLACQGQGLI QAAFLAPGTL
LGAFAAGPRG TQAALCAFPM AELGASMEKA RRLCYTAGGR GPSGAEEATV EYGVTSRCVT
LPLDSPESYP CGDEHTPSPI AGRQPLEVQP LLKLGQPVSA VAALQADGHM IAFLGDTQGQ
LHKVFLHGPQ GQVYHSQQVA PPGSAISPDL LLDSSGSHLY VLTAHQVDRI PVAACPQFPD
CASCLQAQDP LCGWCVLQGR CTRKGECGRA GQPNQWLWSY EEDSHCLHIQ SLLPGHHPRQ
EQGQVTLSIP RLPILDADEY FHCAFGDYES LAHVEGPHVA CVTPPQDQVP LNPPGTDHVT
VPLALMFEDV AVAATNFSFY DCSAVQALEA AAPCRACVGS IWRCHWCPQS SHCVYGEHCP
EGERTIYSAQ EVDVQVRGPG ACPQVEGLAG PHLVPVGWES HLALRVRNLQ HFRGLPASFH
CWLELPGELR GLPATLEETA GDSGLIHCQA HQFYPSMSQR ELPVPIYVTQ GKAQRLDNAR
ALYVILYNCA TGHPDCSHCQ AANRSLGCLW CADGQPACRY GPLCPLGAVE LLCPAPSIDA
VEPLTGPPEG GLALTILGSN LGRAFADVQY AVSVASRPCN PEPSLYRTSA RIVCVTSPAP
NGTTGPVRVA IKSQPPGISS QHFTYQDPVL LSLSPRWGPQ AGGTQLTIRG QHLQTGGNTS
AFVGGQPCPI LEPVCPEAIV CRTRPQAVPG EAAVLVVFGH AQRTLLASPF RYTANPRLVA
AEGGRLIRVR GTGLDAVQRP LLSVWLEADA EVQASRDPEP RSSCGAPAAD PQACIQLGGG
LLQCSTVCSV NSSSLLLCRS PAVPDTARPQ RVFFTLDNVQ VDFASASGGQ GFLYQPNPRL
APLSREGPAR PYRLKPGHVL DVEGEGLNLG ISKEEVRVHI GLGECLVKTL TRTHLYCEPP
AHAPQPANGS GLPQFVVQMG NVQLALGPVQ YEAEPPLSAF PVEAQAGVGM GAAVLIATVL
LLTLMYRHKS KQALRDYQKV LLQLESLETG VGDQCRKEFT DLMTEMTDLS SDLEASGIPF
LDYRTYAERA FFPGHGGCPL QPKPEGPGED GRCATVCQGL TQLSNLLNSK LFLLTLIHTL
EAQPSFSQRD RCHVASLLSL ALHGKLEYLT DIMRTLLGDL AAHHVHRNPK LMLRRTETMV
EKLLTNWLSI CLYAFLRVRG TVPLNTLQHY KVRAVVGWAE QGGAGAGQGE AGQGGSSVGT
WLGVSTASTP HLCQVPDGAT VGLVPQLHSG STISQRSALT WGHWSSGWAT SSPTPPRSSA
HLSFLSSSPH PAPPCRGSGL GIPGQGQAPV PSDIPTLEDG EEGGVCLWHL VKATEEPEGA
KVRCSSLRER EPARAKAIPE IYLTRLLSMK GTLQKFVDDT FQAILSVNRP IPIAVKYLFD
LLDELAEKHG IEDPGTLHIW KTNSLLLRFW VNALKNPQLI FDVRVSDNVD AILAVIAQTF
IDSCTTSEHK VGRDSPVNKL LYAREIPRYK QMVERYYADI RQSSPASYQE MNSALAELSG
NYTSAPHCLE ALQELYNHIH RYYDQIISAL ERPV
//
