ID G1RUC7_NOMLE Unreviewed; 1002 AA.
AC G1RUC7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=Sodium/potassium-transporting ATPase subunit alpha {ECO:0000256|RuleBase:RU362084};
GN Name=ATP12A {ECO:0000313|Ensembl:ENSNLEP00000016852.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000016852.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000016852.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000016852.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362084};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362084}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IIC subfamily. {ECO:0000256|RuleBase:RU362084}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ADFV01075038; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01075039; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01075040; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01075041; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01075042; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01075043; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01075044; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1RUC7; -.
DR STRING; 61853.ENSNLEP00000016852; -.
DR Ensembl; ENSNLET00000017704.3; ENSNLEP00000016852.2; ENSNLEG00000013878.3.
DR eggNOG; KOG0203; Eukaryota.
DR GeneTree; ENSGT00940000159259; -.
DR HOGENOM; CLU_002360_4_1_1; -.
DR InParanoid; G1RUC7; -.
DR OMA; FQDWSTK; -.
DR TreeFam; TF312838; -.
DR Proteomes; UP000001073; Chromosome 5.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008900; F:P-type potassium:proton transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0005391; F:P-type sodium:potassium-exchanging transporter activity; IEA:Ensembl.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR006068; ATPase_P-typ_cation-transptr_C.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR005775; P-type_ATPase_IIC.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01106; ATPase-IIC_X-K; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 2.
DR PANTHER; PTHR43294:SF1; POTASSIUM-TRANSPORTING ATPASE ALPHA CHAIN 2; 1.
DR PANTHER; PTHR43294; SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA; 1.
DR Pfam; PF13246; Cation_ATPase; 1.
DR Pfam; PF00689; Cation_ATPase_C; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00702; Hydrolase; 1.
DR PRINTS; PR00119; CATATPASE.
DR PRINTS; PR00121; NAKATPASE.
DR SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362084};
KW Ion transport {ECO:0000256|RuleBase:RU362084};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362084};
KW Metal-binding {ECO:0000256|RuleBase:RU362084};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU362084};
KW Potassium {ECO:0000256|ARBA:ARBA00022958, ECO:0000256|RuleBase:RU362084};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538,
KW ECO:0000256|RuleBase:RU362084};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362084};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362084}; Transport {ECO:0000256|RuleBase:RU362084}.
FT TRANSMEM 92..110
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362084"
FT TRANSMEM 122..141
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362084"
FT TRANSMEM 272..296
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362084"
FT TRANSMEM 302..325
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362084"
FT TRANSMEM 754..774
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362084"
FT TRANSMEM 780..802
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362084"
FT TRANSMEM 823..848
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362084"
FT TRANSMEM 894..913
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362084"
FT TRANSMEM 933..952
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362084"
FT TRANSMEM 964..980
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362084"
FT DOMAIN 777..987
FT /note="Cation-transporting P-type ATPase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00689"
SQ SEQUENCE 1002 AA; 111597 MW; 53A6728BAEF7A8D7 CRC64;
YSVELSGTKD IVKTDKGDGK EKYRGLKNNC LELKKKNHKE EIQKELHLDD HKLSNRELEE
KYGTDITTGL SSTRAQTPEI IKFLKQMGGK GFSILLWVGA FLCWIAYGIQ YSSDKSASLN
NVYLGCVLGL VVILTGIFAY YQEAKSTNIM STFNKMIPQQ ALVIRDSEKK TIPSEQLVVG
DIVEVKGGDQ IPADIRVLSS QGCRVDNSSL TGESEPQPRS SEFTHENPLE TKNICFYSTT
CLEGTVTGMV INTGDRTIIG HIASLALRNR ALCSYVAGVA VSIGILFFII AVSLKYRVLD
SIIFLIGIIV ANVPEGLLAT VTVTLSLTAK RMAKKNCLVK NLEAVETLGS TSIICSDKTG
TLTQNRMTVA HLWFDNQIFV ADTSEDHSNQ VFDQSSRTWS SLSRYTLCNR ASQPGQKCPI
MKKSVIGDAS ETALLKFSEI ILGDVMEIRK RNRKVAEIPF NSTNKFQLSI HETDDPHDKR
FLMVMKGAPE RILEKCSTIM INGEEHPLDK STAKTFHTAY MELGGLGERV LGFCHLYLPA
DKFPETYSFD IDAMNFPTSN LCFVGLLSMI DPPRSTVPDA VTKCRSAGIK VIMVTGDHPI
TAKAIAKSVG IISANSETVE DIAHRLNIAV EQVNKWDAKA AVVTGMELKD MSSEQLDEIL
ANYQEIVFAR TSPQQKLIIV EGCQRQDAVV AVTGDGVNDS PALKKADIGI AMGIAGSDAA
KNAADMVLLD DNFASIVTGV EEGRLIFDNL KKTIAYTLTK NIAELCPFLI YIIVGLPLPI
GTITLLFIDL GTDIIPSIAL AYEKAESDIM NRKPRHKKKD RLVNQPLAVY SYLHIGLMQA
LGAFLVYFTA YAQEGFLPRT LINLRVEWET DYVNDLEDSY GQEWTRYQRE YLEWMGYTAF
FVGILVQQIA DLIIRKTRRN SIFQQGLFRN KVIWVGIASQ IIIGLILSYG LGSVTALSFT
MLRAQYWFVA VPHAILIWVY DEVRKLFIRL YPGSWWDKNM YY
//
