ID G1RZ60_NOMLE Unreviewed; 183 AA.
AC G1RZ60;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 08-NOV-2023, entry version 57.
DE SubName: Full=TNF superfamily member 4 {ECO:0000313|Ensembl:ENSNLEP00000018537.1};
DE SubName: Full=Tumor necrosis factor ligand 2B {ECO:0000313|EMBL:CTQ86119.1};
GN Name=TNFSF4 {ECO:0000313|Ensembl:ENSNLEP00000018537.1};
GN Synonyms=TNLG2B {ECO:0000313|EMBL:CTQ86119.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000018537.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000018537.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CTQ86119.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26646413; DOI=10.1007/s00251-015-0887-5;
RA Premzl M.;
RT "Comparative genomic analysis of eutherian tumor necrosis factor ligand
RT genes.";
RL Immunogenetics 68:125-132(2016).
RN [3] {ECO:0000313|EMBL:CTQ86119.1}
RP NUCLEOTIDE SEQUENCE.
RX DOI=10.1016/j.genrep.2019.100414;
RA Premzl M.;
RT "Eutherian third-party data gene collections.";
RL Gene Rep 16:100414-100414(2019).
RN [4] {ECO:0000313|Ensembl:ENSNLEP00000018537.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670}.
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DR EMBL; ADFV01184662; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; LN874354; CTQ86119.1; -; mRNA.
DR RefSeq; XP_003258940.1; XM_003258892.2.
DR STRING; 61853.ENSNLEP00000018537; -.
DR Ensembl; ENSNLET00000019465.2; ENSNLEP00000018537.1; ENSNLEG00000015276.2.
DR GeneID; 100599087; -.
DR KEGG; nle:100599087; -.
DR CTD; 7292; -.
DR eggNOG; ENOG502ST4X; Eukaryota.
DR GeneTree; ENSGT00390000015127; -.
DR HOGENOM; CLU_091735_0_0_1; -.
DR OMA; TTHNTSC; -.
DR OrthoDB; 4334524at2759; -.
DR TreeFam; TF336384; -.
DR Proteomes; UP000001073; Chromosome 12.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
DR GO; GO:0071380; P:cellular response to prostaglandin E stimulus; IEA:Ensembl.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0032753; P:positive regulation of interleukin-4 production; IEA:Ensembl.
DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:0032729; P:positive regulation of type II interferon production; IEA:Ensembl.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR021184; TNF_CS.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR042338; TNFSF4.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR17534; OX40 LIGAND; 1.
DR PANTHER; PTHR17534:SF4; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 4; 1.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS00251; TNF_1; 1.
PE 2: Evidence at transcript level;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 24..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 60..183
FT /note="TNF family profile"
FT /evidence="ECO:0000259|SMART:SM00207"
SQ SEQUENCE 183 AA; 21008 MW; 86FDAEC388122237 CRC64;
MERVQPLEDN VGNAARPRFE RNKLLLVASV IQGLGLLLCF TYICLHFSAL QVSHRYPQIQ
SIKVQFTEYK KEKGFILTSQ KEDEIMKVQN NSVIINCDGF YLISLKGYFS QEVNISLHYQ
KDEEPLFQLK KVRSVNSLMV ASLTYKDKVY LNVTTDNTSL DDFHVNGGEL ILIHQNPGEF
CVL
//