ID G1RZ76_NOMLE Unreviewed; 2052 AA.
AC G1RZ76;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Calcium voltage-gated channel subunit alpha1 I {ECO:0000313|Ensembl:ENSNLEP00000018553.2};
GN Name=CACNA1I {ECO:0000313|Ensembl:ENSNLEP00000018553.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000018553.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000018553.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000018553.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01024717; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01024718; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01024719; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01024720; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01024721; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01024722; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01024723; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01024724; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01024725; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01024726; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 61853.ENSNLEP00000018553; -.
DR Ensembl; ENSNLET00000019481.2; ENSNLEP00000018553.2; ENSNLEG00000015272.3.
DR eggNOG; KOG2302; Eukaryota.
DR GeneTree; ENSGT00940000158594; -.
DR HOGENOM; CLU_000540_2_0_1; -.
DR InParanoid; G1RZ76; -.
DR OMA; MMGNIGA; -.
DR TreeFam; TF313555; -.
DR Proteomes; UP000001073; Chromosome 7b.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR GO; GO:0019228; P:neuronal action potential; IEA:Ensembl.
DR GO; GO:0030431; P:sleep; IEA:Ensembl.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 3.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR005445; VDCC_T_a1.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF209; VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR01629; TVDCCALPHA1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 192..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 329..350
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 356..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 748..770
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 790..806
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 826..848
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1135..1153
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1173..1194
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1206..1232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1270..1292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1371..1395
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1451..1468
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1488..1507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1571..1598
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1673..1694
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 154..392
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 626..854
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1133..1405
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1451..1704
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 451..511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 546..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 858..922
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 996..1018
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1721..1748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1830..1852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1898..1917
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1967..2052
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1404..1431
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 463..483
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 553..570
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 574..590
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 998..1018
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1967..1990
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2022..2040
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2052 AA; 227359 MW; 3D7304F6E1816046 CRC64;
MAESASPPSS SAAAPAAEPG VTTEQPGPRS PPSSPPGLEE PLDGADPHVP HPDLAPVAFF
CLRQTTSPRN WCIKMVCNPY PPQPRLIGAL FLSQLNHCVI LGKSCPLWAF IFIAIKWGVI
MSAMPVSQGS CGHRWNKEGM RFKSWMVEYS LDLQNINLSA IRTVRVLRPL KAINRVPSMR
ILVNLLLDTL PMLGNVLLLC FFVFFIFGII GVQLWAGLLR NRCFLEENFT IQGDVALPPY
YQPEEDDEMP FICSLSGDNG IMGCHEIPPL KEQGRECCLS KDDVYDFGAG RQDLNASGLC
VNWNRYYNVC RTGSANPHKG AINFDNIGYA WIVIFQVITL EGWVEIMYYV MDAHSFYNFI
YFILLIIVGS FFMINLCLVV IATQFSETKQ REHRLMLEQR QRYLSSSTVA SYAEPGDCYE
EIFQYVCHIL RKAKRRALGL YQALQSRRQA LGPEAPAPAK PGPHAKEPRH YNGKIKGQGV
EGRHLGSRHC QTLQGPASPG NDHSLGKRQL CPQHSPLDVT AHTLVQPIPA MLASDPASCP
CCQHEAGRRP SGLGSTDSGQ EGSGSGSSTG GEDEADGDEA RSSEDRASSE LGKEEEEEEQ
ADGAVWLCGD VWRETRAKLR GIVDSKYFNR GIMMAILVNT VSMGIEHHEQ PEELTNILEI
CNVVFTSMFA LEMILKLAAF GLFDYLRNPY NIFDSIIVII SIWEIVGQAD GGLSVLRTFR
LLRVLKLVRF MPALRRQLVV LMKTMDNVAT FCMLLMLFIF IFSILGMHIF GCKFSLRTDT
GDTVPDRKNF DSLLWAIVTV FQILTQEDWN VVLYNGMAST SPWASLYFVA LMTFGNYVLF
NLLVAILVEG FQAEGDANRS YTDEDQSSSN MEEFDKLQEG LDSSGDPKLC PIPMTPNGHL
DPSLPLGGHL GPAGAAGPAP RLSLQPDPML VALGSRKSSV MSLGRMSYDQ RSLVSPCGEL
WMGASSKVRQ GPCLLHSWVP SARVAADEGP PRAAPLHAPH THHAHHGPHL AHRHRHHRRT
LSLDNRDSVD LAELVPAVGA HPRAAWRAAG PVPGHEDCNG RMPSIAKDVF TKMGDRGDRG
EDEEEIDYTL CFRVRKMIDV YKPDWCEVRE DWSVYLFSPE NRFRVLCQTI IAHKLFDYVV
LAFIFLNCIT IALERPQIEA GSTERIFLTV SNYIFTAIFV GEMTLKVVSL GLYFGEQAYL
RSSWNVLDGF LVFVSIIDIV VSLASAGGAK ILGVLRVLRL LRTLRPLRVI SRAPGLKLVV
ETLISSLKPI GNIVLICCAF FIIFGILGVQ LFKGKFYHCL GVDTRNITNR SDCMAANYRW
VHHKYNFDNL GQALMSLFVL ASKDGWVNIM YNGLDAVAVD QQPVTNHNPW MLLYFISFLL
IVSFFVLNMF VGVVVENFHK CRQHQEAEEA RRREEKRLRR LEKKRRKAQR LPYYATYCHT
RLLIHSMCTS HYLDIFITFI ICLNVVTMSL EHYNQPTSLE TALKYCNYMF TTVFVLEAVL
KLVAFGLRRF FKDRWNQLDL AIVLLSVMGI TLEEIEINAA LPINPTIIRI MRVLRIARVL
KLLKMATGMR ALLDTVVQAL PQVGNLGLLF MLLFFIYAAL GVELFGKLVC NDENPCEGMS
RHATFENFGM AFLTLFQVST GDNWNGIMKD TLRDCTHDER SCLSSLQFVS PLYFVSFVLT
AQFVLINVVV AVLMKHLDDS NKEAQEDAEM DAELELEMAH GLGPGPRLPA GSPGAPGRGP
GGAGGGGDTE GGLCRRCYSP AQVGVWTFLT TARSLFRASG LWLHAPGPRS AHPNPGVTRG
HPLFLQVQLA ETEAFSLNSD RSSSILLGDD LSLEDPTACP PGPKDSKGEL DPPEPMHVGD
LGECFFPLSS TAVSPDPENF LCEMEEIPFN PVRSWLKHES SQAPPSPFSP DASSPLLPMP
AEFFHPAVSA SQKGPEKGTG TGTLPKIALQ GSWASLRSPR VNCTLLRQVP TPPRPQSTGL
KFSSTSSLAA PGRPRAAALA HGLARSPSWA ADRSKDPPGR APMPMGLGPL APPPQPLPGE
LEPGDAASKR KR
//
