ID G1S1U6_NOMLE Unreviewed; 486 AA.
AC G1S1U6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Protein kinase C and casein kinase substrate in neurons 2 {ECO:0000313|Ensembl:ENSNLEP00000019484.1};
GN Name=PACSIN2 {ECO:0000313|Ensembl:ENSNLEP00000019484.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000019484.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000019484.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000019484.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004413};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cell projection,
CC ruffle membrane {ECO:0000256|ARBA:ARBA00004599}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004599}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004599}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Early endosome
CC {ECO:0000256|ARBA:ARBA00004412}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004608}. Membrane, caveola
CC {ECO:0000256|ARBA:ARBA00004345}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}. Recycling endosome membrane
CC {ECO:0000256|ARBA:ARBA00004565}.
CC -!- SIMILARITY: Belongs to the PACSIN family.
CC {ECO:0000256|ARBA:ARBA00010461}.
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DR EMBL; ADFV01025134; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01025135; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01025136; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01025137; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01025138; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01025139; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003264898.1; XM_003264850.2.
DR RefSeq; XP_004088461.1; XM_004088413.2.
DR AlphaFoldDB; G1S1U6; -.
DR STRING; 61853.ENSNLEP00000019484; -.
DR Ensembl; ENSNLET00000020470.2; ENSNLEP00000019484.1; ENSNLEG00000016046.2.
DR GeneID; 100585150; -.
DR KEGG; nle:100585150; -.
DR CTD; 11252; -.
DR eggNOG; KOG2856; Eukaryota.
DR GeneTree; ENSGT00950000182973; -.
DR HOGENOM; CLU_030752_0_0_1; -.
DR InParanoid; G1S1U6; -.
DR OMA; PDSLGWC; -.
DR OrthoDB; 9421at2759; -.
DR TreeFam; TF313677; -.
DR Proteomes; UP000001073; Chromosome 7b.
DR GO; GO:0005901; C:caveola; IEA:UniProtKB-SubCell.
DR GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
DR GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0070300; F:phosphatidic acid binding; IEA:Ensembl.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR GO; GO:0070836; P:caveola assembly; IEA:Ensembl.
DR GO; GO:0072584; P:caveolin-mediated endocytosis; IEA:Ensembl.
DR GO; GO:0048858; P:cell projection morphogenesis; IEA:Ensembl.
DR GO; GO:0050804; P:modulation of chemical synaptic transmission; IEA:Ensembl.
DR GO; GO:0045806; P:negative regulation of endocytosis; IEA:Ensembl.
DR GO; GO:0097320; P:plasma membrane tubulation; IEA:Ensembl.
DR GO; GO:0036010; P:protein localization to endosome; IEA:Ensembl.
DR CDD; cd07679; F-BAR_PACSIN2; 1.
DR CDD; cd11998; SH3_PACSIN1-2; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR035743; PACSIN1/PACSIN2_SH3.
DR InterPro; IPR037453; PACSIN2_F-BAR.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR23065:SF14; PROTEIN KINASE C AND CASEIN KINASE SUBSTRATE IN NEURONS PROTEIN 2; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PROSITE-
KW ProRule:PRU01077}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 11..282
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 426..486
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 313..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..368
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 386..423
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 486 AA; 55810 MW; 03C1735E3AB21EB5 CRC64;
MSVTYDDSVG VEVSSDSFWE VGNYKRTVKR IDDGHRLCSD LMNCLHERAR IEKAYAQQLT
EWARRWRQLV EKGPQYGTVE KAWMAFMSEA ERVSELHLEV KASLMNDDFE KIKNWQKEAF
HKQMMGGFKE TKEAEDGFRK AQKPWAKKLK EVEAAKKAHH AACKEEKLAI SREANSKADP
SLNPEQLKKL QDKIEKCKQD VLKTKEKYEK SLKELDQGTP QYMENMEQVF EQCQQFEEKR
LRFFREVLLE VQKHLDLSNV TGYKAIYHDL EQSIRAADAV EDLRWFRANH GPGMAMNWPQ
FEEWSADLNR TLSRREKKKA TDGVTLTGIN QTGDQSLPNK PSSTLNVPSN PAQSAQSQSS
YNPFEDEDDT GSTVSEKEDT KAKNVSSYEK TQSYPTDWSD DESNNPFSST DANGDSNPFD
DDATSGTEVR VRALYDYEGQ EHDELSFKAG DELTKMEDED EQGWCKGRLD NGQVGLYPAN
YVEAIQ
//
