ID G1S2C0_NOMLE Unreviewed; 510 AA.
AC G1S2C0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Eukaryotic translation initiation factor 2 alpha kinase 2 {ECO:0000313|Ensembl:ENSNLEP00000019658.2};
GN Name=EIF2AK2 {ECO:0000313|Ensembl:ENSNLEP00000019658.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000019658.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000019658.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000019658.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01011820; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01011821; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01011822; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01011823; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01011824; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01011825; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1S2C0; -.
DR Ensembl; ENSNLET00000020650.2; ENSNLEP00000019658.2; ENSNLEG00000016201.3.
DR eggNOG; KOG1033; Eukaryota.
DR GeneTree; ENSGT00940000160736; -.
DR HOGENOM; CLU_023682_1_0_1; -.
DR TreeFam; TF317576; -.
DR Proteomes; UP000001073; Chromosome 19.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003725; F:double-stranded RNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd19903; DSRM_EIF2AK2_rpt1; 1.
DR CDD; cd19904; DSRM_EIF2AK2_rpt2; 1.
DR Gene3D; 3.30.160.20; -; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR044452; EIF2AK2_DSRM_1.
DR InterPro; IPR044453; EIF2AK2_DSRM_2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR11042; EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED; 1.
DR PANTHER; PTHR11042:SF163; INTERFERON-INDUCED, DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE; 1.
DR Pfam; PF00035; dsrm; 2.
DR Pfam; PF00069; Pkinase; 1.
DR PIRSF; PIRSF000615; TyrPK_CSF1-R; 2.
DR SMART; SM00358; DSRM; 2.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50137; DS_RBD; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW Magnesium {ECO:0000256|PIRSR:PIRSR000615-3};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000615-3};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266}.
FT DOMAIN 9..77
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 100..167
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 171..497
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 203..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 481..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 373
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-1"
FT BINDING 378
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-3"
FT BINDING 391
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-3"
SQ SEQUENCE 510 AA; 57261 MW; 949162D70A60BEFA CRC64;
MAGDLSAGFF MEELNTYRQK QGVVLRYQEL PNSGPPHDRR FTFRVIIDER EFPEAEGRSK
KEAKNAAAKL AVEILNKEKK GVSPLVLTTT SSSEGLSIGN YMGLINRFAQ KKRLTVNYEQ
CVSGVHGPKG FHYKCKMGQK EYSIGTGSTK QEAKQLAAKL AYVQILSEDT SVKSDSMSSG
SFAATCDSQS SSLVTSTLAS ASSSEGDFSA DTSEINSNSD SLNNSSLLMN GLRNNQRKAK
RSLAPTFDPP DMKGTKYTVD KRKVEREVKA LAKLDHVNIV KYNGCWDGFD YDPETSSYDP
ESDDYDPENS KNSSRSKTKC LFIQMEFCDK GTLEQWIDNR RGKKLDKVLA LEFFEQITKG
VDYIHSKKLI HRDLKPSNIF LVDTKQIKIG DFGLVTSLKN DGKRSRSTGT LRYMSPEQIS
LQDYGKEVDL YALGLILAEL LHVCDTAYET AKFFTDLRDG IISDVFDKKE KTLLQKLLSK
KPEDRPNTSE ILSTLTVWKK SPEKNERHTR
//
