ID G1S2U1_NOMLE Unreviewed; 346 AA.
AC G1S2U1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Ras-related GTP-binding protein {ECO:0000256|RuleBase:RU367014};
GN Name=RRAGB {ECO:0000313|Ensembl:ENSNLEP00000019829.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000019829.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000019829.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000019829.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Guanine nucleotide-binding protein that plays a crucial role
CC in the cellular response to amino acid availability through regulation
CC of the mTORC1 signaling cascade. {ECO:0000256|RuleBase:RU367014}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU367014}.
CC Lysosome {ECO:0000256|RuleBase:RU367014}. Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004656}.
CC -!- SIMILARITY: Belongs to the GTR/RAG GTP-binding protein family.
CC {ECO:0000256|ARBA:ARBA00007756, ECO:0000256|RuleBase:RU367014}.
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DR EMBL; ADFV01094297; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01094298; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01094299; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01094300; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01094301; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01094302; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003276376.1; XM_003276328.2.
DR AlphaFoldDB; G1S2U1; -.
DR Ensembl; ENSNLET00000020826.3; ENSNLEP00000019829.2; ENSNLEG00000016350.3.
DR GeneID; 100579446; -.
DR KEGG; nle:100579446; -.
DR CTD; 10325; -.
DR eggNOG; KOG3886; Eukaryota.
DR GeneTree; ENSGT00950000183031; -.
DR HOGENOM; CLU_044099_1_0_1; -.
DR OrthoDB; 33171at2759; -.
DR TreeFam; TF300616; -.
DR Proteomes; UP000001073; Chromosome X.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0071230; P:cellular response to amino acid stimulus; IEA:UniProtKB-UniRule.
DR GO; GO:0032008; P:positive regulation of TOR signaling; IEA:UniProtKB-UniRule.
DR CDD; cd11384; RagA_like; 1.
DR Gene3D; 3.30.450.190; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR006762; Gtr1_RagA.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039397; RagA/B.
DR PANTHER; PTHR11259; RAS-RELATED GTP BINDING RAG/GTR YEAST; 1.
DR PANTHER; PTHR11259:SF4; RAS-RELATED GTP-BINDING PROTEIN B; 1.
DR Pfam; PF04670; Gtr1_RagA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU367014};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU367014};
KW Lysosome {ECO:0000256|RuleBase:RU367014};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU367014};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 346 AA; 40202 MW; C1F693141C63A93F CRC64;
MEESDSEKTM EKENLGPRMD PPLGEPEGSL GWVLPNTAMK KKVLLMGKSG SGKTSMRSII
FANYIARDTR RLGATIDVEH SHVRFLGNLV LNLWDCGGQD TFMENYFTSQ RDNIFRNVEV
LIYVFDVESR ELEKDMHYYQ SCLEAILQNS PDAKIFCLVH KMDLVQEDQR DLIFKEREED
LRRLSRPLEC SCFRTSIWDE TLYKAWSSIV YQLIPNVQQL EMNLRNFAEI IEADEVLLFE
RATFLVISHY QCKEQRDAHR FEKISNIIKQ FKLSCSKLAA SFQSMEVRNS NFAAFIDIFT
SNTYVMVVMS DPSIPSAATL INIRNARKHF EKLERVDGPK QCLLMR
//
