ID   G1S402_NOMLE            Unreviewed;       846 AA.
AC   G1S402;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   27-MAR-2024, entry version 55.
DE   SubName: Full=MET transcriptional regulator MACC1 {ECO:0000313|Ensembl:ENSNLEP00000020240.2};
GN   Name=MACC1 {ECO:0000313|Ensembl:ENSNLEP00000020240.2};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000020240.2, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000020240.2, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000020240.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; ADFV01001508; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; G1S402; -.
DR   Ensembl; ENSNLET00000021250.3; ENSNLEP00000020240.2; ENSNLEG00000016683.3.
DR   eggNOG; ENOG502QZDM; Eukaryota.
DR   GeneTree; ENSGT00390000013151; -.
DR   HOGENOM; CLU_013080_1_0_1; -.
DR   TreeFam; TF105572; -.
DR   Proteomes; UP000001073; Chromosome 11.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   CDD; cd01670; Death; 1.
DR   Gene3D; 2.60.220.30; -; 1.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR000906; ZU5_dom.
DR   PANTHER; PTHR15603:SF1; METASTASIS-ASSOCIATED IN COLON CANCER PROTEIN 1; 1.
DR   PANTHER; PTHR15603; SH3 DOMAIN-CONTAINING PROTEIN; 1.
DR   PROSITE; PS50002; SH3; 1.
DR   PROSITE; PS51145; ZU5; 1.
PE   4: Predicted;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          212..349
FT                   /note="ZU5"
FT                   /evidence="ECO:0000259|PROSITE:PS51145"
FT   DOMAIN          550..620
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
SQ   SEQUENCE   846 AA;  96158 MW;  B771B10B477B54F7 CRC64;
     MLITERKHFS LGRIAQSRSE ANLIDMEAGK LSKSCNITEC QDPDLLHNWP DAFTLHGNNA
     SKVKNPFWSQ LSASNPFLDD ITQLRNNRKR NNISILKEDP FLFFREIENG NSFDSSGDEL
     DVHQLLRQSS SRKSGRSKSV SELLDILDDT AHAHQSIHNS DQILPHDLEW LKNDREAYKM
     AWLSQRQLAR SCLDLNTISQ SPGWAQTQLA EVTITCKVNH QGGSVQLPES DITVHVPQGH
     VAVGEFQEVS LRAFLDPPHM LNHDLSCTVS PLLEIMLGNL NTMEALLLEM KIGAEVRKDP
     FSQVMTEMVC LHSLGKEGPF KVLSNCYIYK DTIQVKLIEL SQVMYLVVAA QAKALQSPAA
     TIWDYIHKTT SVGIYGPKYI HPSFTVILTV CGHSYMPGQL TISDIKKGGR KNISPVVFQL
     WGKQSFLLDK PQDLSISVFS CDPDFEVKTE GERKEIKQKQ LEAGEVVHQQ FLFSLVEHRE
     MHLFEFCVQV EPLNGELVAQ FSITTPDPNP NLKRLSNLPG YLQKKEEIKS APLSPKILVK
     YPTFQDKTLN FTNYGVTLKA VLRQSKIDYF LEYFKGDTIA LLGEGKVKAI GQSKVKEWYV
     GLLRGKIGLV HCKNVKVISK QQVMFMSDSV FTTRNLLEQI VLPLKKLTYI YSVVLTLVSE
     KVYDWKVLAD VLGYSHLSLE DFDQIQADKE SEKVSYVIKK LKEDCHTERN TRKFLYELTV
     ALLKMDCQAL VARLIQEAAI LTSAVKLGKG WRELAEKLVR LTKQQMEAYE IPHRGNTGDV
     AVEMMWKPAY DFLYTWSAHY GNNYRDVLQD LQSALDRMKN PVTKHWRELT GVLILVNSLE
     VLRVTK
//