ID G1S485_NOMLE Unreviewed; 209 AA.
AC G1S485;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Hypoxanthine phosphoribosyltransferase {ECO:0000256|RuleBase:RU364099};
DE EC=2.4.2.8 {ECO:0000256|RuleBase:RU364099};
GN Name=PRTFDC1 {ECO:0000313|Ensembl:ENSNLEP00000020323.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000020323.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000020323.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000020323.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate +
CC hypoxanthine; Xref=Rhea:RHEA:17973, ChEBI:CHEBI:17368,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:58017, ChEBI:CHEBI:58053; EC=2.4.2.8;
CC Evidence={ECO:0000256|RuleBase:RU364099};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|RuleBase:RU364099};
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway; IMP
CC from hypoxanthine: step 1/1. {ECO:0000256|RuleBase:RU364099}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU364099}.
CC -!- SIMILARITY: Belongs to the purine/pyrimidine phosphoribosyltransferase
CC family. {ECO:0000256|ARBA:ARBA00008391, ECO:0000256|RuleBase:RU364099}.
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DR EMBL; ADFV01049898; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01049899; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01049900; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01049901; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01049902; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01049903; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01049904; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1S485; -.
DR STRING; 61853.ENSNLEP00000020323; -.
DR Ensembl; ENSNLET00000021338.3; ENSNLEP00000020323.2; ENSNLEG00000016746.3.
DR eggNOG; KOG3367; Eukaryota.
DR GeneTree; ENSGT00940000162225; -.
DR HOGENOM; CLU_073615_3_0_1; -.
DR InParanoid; G1S485; -.
DR OMA; VIFMEDI; -.
DR TreeFam; TF313367; -.
DR UniPathway; UPA00591; UER00648.
DR Proteomes; UP000001073; Chromosome 18.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0052657; F:guanine phosphoribosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0004422; F:hypoxanthine phosphoribosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0032264; P:IMP salvage; IEA:UniProtKB-UniPathway.
DR GO; GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW.
DR CDD; cd06223; PRTases_typeI; 1.
DR Gene3D; 3.40.50.2020; -; 1.
DR InterPro; IPR005904; Hxn_phspho_trans.
DR InterPro; IPR000836; PRibTrfase_dom.
DR InterPro; IPR029057; PRTase-like.
DR NCBIfam; TIGR01203; HGPRTase; 1.
DR PANTHER; PTHR43340; HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE; 1.
DR PANTHER; PTHR43340:SF5; PHOSPHORIBOSYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00156; Pribosyltran; 1.
DR SUPFAM; SSF53271; PRTase-like; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU364099};
KW Glycosyltransferase {ECO:0000256|RuleBase:RU364099};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|RuleBase:RU364099};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU364099};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU364099};
KW Purine salvage {ECO:0000256|RuleBase:RU364099};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transferase {ECO:0000256|RuleBase:RU364099}.
FT DOMAIN 31..186
FT /note="Phosphoribosyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00156"
SQ SEQUENCE 209 AA; 24091 MW; C4D0DD50A91DF0FE CRC64;
IMDDWPGYDL NLFTYPQHYY GDLEYVLIPH GIIVDRIERL AKDIMKDIGY SDIMVLCVLK
GGYKFCADLV EHLKNISRNS DRFVSMKVDF IRLKSYRNDQ SMGEMQIIGG DDLSTLAGKN
VLIVEDVVGT GRTMKALLSN IEKYKPNMIK VASLLVKRTP RSDGFRPDYA GFEIPNLFVV
GYALDYNEYF RDLNHICVIN EHGKEKYRI
//
