ID G1S5G0_NOMLE Unreviewed; 1676 AA.
AC G1S5G0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Complement C5 {ECO:0000313|Ensembl:ENSNLEP00000020748.1};
GN Name=C5 {ECO:0000313|Ensembl:ENSNLEP00000020748.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000020748.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000020748.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000020748.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; ADFV01020086; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01020087; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01020088; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01020089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01020090; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01020091; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01020092; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01020093; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01020094; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003264119.1; XM_003264071.2.
DR STRING; 61853.ENSNLEP00000020748; -.
DR Ensembl; ENSNLET00000021785.3; ENSNLEP00000020748.1; ENSNLEG00000017065.3.
DR GeneID; 100606437; -.
DR KEGG; nle:100606437; -.
DR CTD; 727; -.
DR eggNOG; KOG1366; Eukaryota.
DR GeneTree; ENSGT00940000155670; -.
DR HOGENOM; CLU_001634_4_2_1; -.
DR InParanoid; G1S5G0; -.
DR OMA; YKRIIAC; -.
DR OrthoDB; 4033541at2759; -.
DR TreeFam; TF313285; -.
DR Proteomes; UP000001073; Chromosome 8.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0005579; C:membrane attack complex; IEA:Ensembl.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0006957; P:complement activation, alternative pathway; IEA:UniProtKB-KW.
DR GO; GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0010760; P:negative regulation of macrophage chemotaxis; IEA:Ensembl.
DR GO; GO:0032722; P:positive regulation of chemokine production; IEA:Ensembl.
DR GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR CDD; cd00017; ANATO; 1.
DR CDD; cd02896; complement_C3_C4_C5; 1.
DR CDD; cd03582; NTR_complement_C5; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 3.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 6.20.50.160; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 1.20.91.20; Anaphylotoxins (complement system); 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR000020; Anaphylatoxin/fibulin.
DR InterPro; IPR018081; Anaphylatoxin_comp_syst.
DR InterPro; IPR001840; Anaphylatoxn_comp_syst_dom.
DR InterPro; IPR041425; C3/4/5_MG1.
DR InterPro; IPR048843; C5_CUB.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR040839; MG4.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR11412:SF83; COMPLEMENT C5; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01821; ANATO; 1.
DR Pfam; PF21309; C5_CUB; 1.
DR Pfam; PF17790; MG1; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF17789; MG4; 1.
DR Pfam; PF01759; NTR; 1.
DR Pfam; PF07678; TED_complement; 1.
DR PRINTS; PR00004; ANAPHYLATOXN.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM00104; ANATO; 1.
DR SMART; SM00643; C345C; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF47686; Anaphylotoxins (complement system); 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS01177; ANAPHYLATOXIN_1; 1.
DR PROSITE; PS01178; ANAPHYLATOXIN_2; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Complement alternate pathway {ECO:0000256|ARBA:ARBA00023162};
KW Complement pathway {ECO:0000256|ARBA:ARBA00022875};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1676
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003420811"
FT DOMAIN 698..732
FT /note="Anaphylatoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS01178"
FT DOMAIN 1532..1676
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
SQ SEQUENCE 1676 AA; 188045 MW; 489E51F7572BAE9D CRC64;
MGLLGILCFL IFLGKTWGQE QTYVISAPKI FRVGASENIV IQVYGYTEAF DATISIKSYP
DKKFSYSSGH VHLSSENKFQ NSAVLTIQPK QLPGGQNPVS HVYLEVVSKH FSKSKKMPIT
YDNGFLFIHT DKPVYTPDQS VKVRVYSLND DLKPAKRETV LTFIDPEGSE VDMVEEIDHI
GIISFPDFKI PSNPRYGMWT IKAKYKEDFS TTGTAYFEVK EYVLPHFSVS IEPECNFISY
KNFKNFEISI KARYFYNKVV TEADVYITFG IREDLKDDQK EMMQTAMQTT MLINGIAQVT
FDSETAVKEL SYYSLEDLNN KYLYIAVTVI ESTGGFSEEA EIPGIKYVLS PYKLNLVATP
LFLKPGIPYS IKVQVKDSLD QLVGGVPVTL NAQTIDVNQE PSDLDPSKSV TRVDDGVASF
VLNLPSGVTV LEFNVKTDAP DLPEENQARE GYRAIAYSSL SQSYLYIDWT DNHKALLVGE
HLNIIVTPKS PYIDKITHYN YLVLSKGKII HFGTREKFSD ASYQSINIPV TQNMVPSSRL
LVYYIVTGEQ TAELVSDSVW LNIEEKCGNQ LQVHLSPDAD VYSPGQTVSL NMASGMDSWV
ALAAVDSAVY GVQRRAKKPL ERVFQFLEKS DLGCGAGGGL NNANVFYLAG LTFLTNANAD
DSQENDEPCK EILRPRRMLQ KKIEEIAAKY KHSVVKKCCY DGASVNNDET CEQRAARITV
GPRCIKAFTE CCVVASQHRA NSSYKDIQLG RLHMKTLLPV SKPEIRSYFP ESWLWEVHLV
PRRKQLQFAL PDSLTTWEIQ GVGISNSGIC VADTVKANVF KDVFLEMNIP YSVVRGEQVQ
LKGTVYNYRT SGMQFCVKMS AVEGICTSES PAIDHQGTKS SKCVRQKVEG SSSHLVTLTV
LPLEIGLHNI NFSLETSFGK EILVKTLRVV PEGVKRESYS GVTLDPRGIY GTISRRKEFP
YRIPLDLVPK TEIKRILSVK GLLVGEILSA VLSQEGINIL THLPKGSAEA ELMSVVPVFY
VFHYLETGNH WNIFHSDPLI EKQKLKKKLK EGMLSIMSYR NADYSYSVWK GGSASTWLTA
FALRVLGQVN KYVEQNQNSI CNSLLWLVEN YQLDNGSFQE NSQYQPIKLQ GTLPVEAREN
SLYLTAFTVI GIRKAFDICP LVKIDTALIK ADNFLLENTL PAQSTFTLAI SAYALSLGDK
THPQFRSIVS ALKRAALVKG NPPIYRFWKD SLQHKDSSVP NTGTARMVET TAYALLTSLN
LKDINYVNPI IKWLSEEQRY GGGFYSTQDT INAIEGLTEY SLLVKQLRLN MDIDVAYKHK
GALHNYKMTD KNFLGRPIEV LLNDDLIVST GFGSGLATVH VTTVVHKTST SEEVCSFYLK
IDTQDIEASH YRGYGNADYK RIVACASYKP SREESSSGSS HAVMDISLPT GISANEEDLK
ALVEGVDQLF TDYQIKDGHV ILQLNSIPSS DFLCVRFRIF ELFEVGFLSP ATFTVYEYHR
PDKQCTMFYS TSNIKIQKVC EGAACKCVEA DCGQMQKELD LTISAETRKQ TACKPEIAYA
YKVSITSITV ENVFVKYKAT LLDIYKTGEA VAEKDSEITF IKKVTCTNAE LVKGRQYLIM
GKEALQIKYN FSFRYIYPLD SLTWIEYWPR DTTCSSCQAF LANLDEFAED IFLNGC
//
