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Database: UniProt
Entry: G1S6A6_NOMLE
LinkDB: G1S6A6_NOMLE
Original site: G1S6A6_NOMLE 
ID   G1S6A6_NOMLE            Unreviewed;       475 AA.
AC   G1S6A6;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   24-JAN-2024, entry version 72.
DE   RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE            EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN   Name=TRIM21 {ECO:0000313|Ensembl:ENSNLEP00000021044.1};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000021044.1, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000021044.1, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000021044.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   -!- SIMILARITY: Belongs to the TRIM/RBCC family.
CC       {ECO:0000256|ARBA:ARBA00008518}.
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DR   EMBL; ADFV01111865; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003254849.1; XM_003254801.1.
DR   RefSeq; XP_012359625.1; XM_012504171.1.
DR   AlphaFoldDB; G1S6A6; -.
DR   STRING; 61853.ENSNLEP00000021044; -.
DR   Ensembl; ENSNLET00000022101.3; ENSNLEP00000021044.1; ENSNLEG00000017330.3.
DR   GeneID; 100601201; -.
DR   KEGG; nle:100601201; -.
DR   eggNOG; KOG2177; Eukaryota.
DR   GeneTree; ENSGT00940000161515; -.
DR   HOGENOM; CLU_013137_0_3_1; -.
DR   InParanoid; G1S6A6; -.
DR   OMA; NSGKFYW; -.
DR   OrthoDB; 3453019at2759; -.
DR   TreeFam; TF338674; -.
DR   Proteomes; UP000001073; Chromosome 15.
DR   GO; GO:0010494; C:cytoplasmic stress granule; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0003713; F:transcription coactivator activity; IEA:Ensembl.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045824; P:negative regulation of innate immune response; IEA:Ensembl.
DR   GO; GO:0090086; P:negative regulation of protein deubiquitination; IEA:Ensembl.
DR   GO; GO:0032897; P:negative regulation of viral transcription; IEA:Ensembl.
DR   GO; GO:0010508; P:positive regulation of autophagy; IEA:Ensembl.
DR   GO; GO:0045787; P:positive regulation of cell cycle; IEA:Ensembl.
DR   GO; GO:0046598; P:positive regulation of viral entry into host cell; IEA:Ensembl.
DR   GO; GO:0010498; P:proteasomal protein catabolic process; IEA:Ensembl.
DR   GO; GO:0051865; P:protein autoubiquitination; IEA:Ensembl.
DR   GO; GO:0031648; P:protein destabilization; IEA:Ensembl.
DR   GO; GO:0044314; P:protein K27-linked ubiquitination; IEA:Ensembl.
DR   GO; GO:0070936; P:protein K48-linked ubiquitination; IEA:Ensembl.
DR   GO; GO:0085020; P:protein K6-linked ubiquitination; IEA:Ensembl.
DR   GO; GO:0070534; P:protein K63-linked ubiquitination; IEA:Ensembl.
DR   GO; GO:0006513; P:protein monoubiquitination; IEA:Ensembl.
DR   GO; GO:0070269; P:pyroptosis; IEA:Ensembl.
DR   GO; GO:0034341; P:response to type II interferon; IEA:Ensembl.
DR   GO; GO:0035617; P:stress granule disassembly; IEA:Ensembl.
DR   GO; GO:0044790; P:suppression of viral release by host; IEA:Ensembl.
DR   CDD; cd19772; Bbox2_TRIM21_C-IV; 1.
DR   CDD; cd16596; RING-HC_TRIM21_C-IV; 1.
DR   CDD; cd12900; SPRY_PRY_TRIM21; 1.
DR   Gene3D; 2.60.120.920; -; 1.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR003879; Butyrophylin_SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR006574; PRY.
DR   InterPro; IPR035831; PRY/SPRY_TRIM21.
DR   InterPro; IPR003877; SPRY_dom.
DR   InterPro; IPR000315; Znf_B-box.
DR   InterPro; IPR020457; Znf_B-box_chordata.
DR   InterPro; IPR018957; Znf_C3HC4_RING-type.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   PANTHER; PTHR24103; E3 UBIQUITIN-PROTEIN LIGASE TRIM; 1.
DR   PANTHER; PTHR24103:SF46; E3 UBIQUITIN-PROTEIN LIGASE TRIM21; 1.
DR   Pfam; PF13765; PRY; 1.
DR   Pfam; PF00622; SPRY; 1.
DR   Pfam; PF00643; zf-B_box; 1.
DR   Pfam; PF00097; zf-C3HC4; 1.
DR   PRINTS; PR01406; BBOXZNFINGER.
DR   PRINTS; PR01407; BUTYPHLNCDUF.
DR   SMART; SM00336; BBOX; 1.
DR   SMART; SM00589; PRY; 1.
DR   SMART; SM00184; RING; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS50119; ZF_BBOX; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00024}.
FT   DOMAIN          16..55
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   DOMAIN          87..128
FT                   /note="B box-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50119"
FT   DOMAIN          268..467
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000259|PROSITE:PS50188"
FT   COILED          132..217
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   475 AA;  54174 MW;  0709440F72643661 CRC64;
     MASAARLTMM WEEVTCPVCL DPFVEPVSIE CGHSFCQECI SQVGKGVGSV CPVCRQRFLL
     KNLRPNRQLA NMVNNLREIS QEAREGTQGE QCAVHGERLQ LFCEKDGKAL CWVCAQSRKH
     RDHTMVPLEE AAQEYQEKLQ VALGELRRKQ ELAEKLEVEI AMKRADWKKT VETQKSRIHA
     EFVQQKNFLV EEEQRQLQEL EKDEREQLRI LGQKEAKLAQ QGQALQELIS ELDRRCHGSA
     LELLQEVIIV LERSESWNLK DLDIASPELR SVCHVPGLKK MLRTCAVHIT LDPDTANPWL
     ILSEDRRQVR LGDTQQSIPG NEERFDSYPM VLGAQHFHSG KHYWEVDVTG KEAWDLGVCR
     DSVRRKGHFL LSSKSGFWTI WLWNKQKYEA GTYPQTPLHL QVPPCQVGIF LDYEAGMVSF
     YNITDHGSLI YSFSECAFTG PLRPFFSPGF NDGGRNTAPL TLCPLNIGSQ GSTDY
//
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