ID   G1S7R4_NOMLE            Unreviewed;       551 AA.
AC   G1S7R4;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 3.
DT   27-MAR-2024, entry version 67.
DE   SubName: Full=Keratin 75 {ECO:0000313|Ensembl:ENSNLEP00000021553.3};
GN   Name=KRT75 {ECO:0000313|Ensembl:ENSNLEP00000021553.3};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000021553.3, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000021553.3, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000021553.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000256|RuleBase:RU000685}.
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DR   EMBL; ADFV01002827; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; G1S7R4; -.
DR   STRING; 61853.ENSNLEP00000021553; -.
DR   Ensembl; ENSNLET00000022644.2; ENSNLEP00000021553.3; ENSNLEG00000017753.2.
DR   eggNOG; ENOG502RTYA; Eukaryota.
DR   GeneTree; ENSGT00940000155862; -.
DR   HOGENOM; CLU_012560_6_1_1; -.
DR   InParanoid; G1S7R4; -.
DR   OMA; SIKKQCS; -.
DR   TreeFam; TF317854; -.
DR   Proteomes; UP000001073; Chromosome 11.
DR   GO; GO:0001533; C:cornified envelope; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:UniProt.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.20.5.500; Single helix bin; 1.
DR   Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR032444; Keratin_2_head.
DR   InterPro; IPR003054; Keratin_II.
DR   PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR45616:SF13; KERATIN, TYPE II CYTOSKELETAL 75; 1.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF16208; Keratin_2_head; 1.
DR   PRINTS; PR01276; TYPE2KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 3.
DR   SUPFAM; SSF46579; Prefoldin; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW   ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT   DOMAIN          149..462
FT                   /note="IF rod"
FT                   /evidence="ECO:0000259|PROSITE:PS51842"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          530..551
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          153..259
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          360..440
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   551 AA;  59517 MW;  91EA8607AD2C9028 CRC64;
     MSRQSSITFQ SGSRRGFSTT SATTPAAGRS RFSSVSVARS AVGSGGLGRI SSAGASFGSR
     SLYNLGGAKR VSISGCGSSF RSGFGGRASQ GFGVNSGFGY GGGVGGGFSG PSFPVCPAGG
     IQEVTVNQSL LTPLNLQIDP TIQRVRAEER EQIKTLNNKF AAFIDKVRFL EQQNKVLETK
     WALLQEQGSR TVRQNLEPLF DSYISEFRRQ LESVTTERGR LEAELRNMQD VVEDFKIRYE
     DEINKRTAAE NEFVALKKDV DAAYMNKVEL EAKVKSLPEE INFLHSVFDA ELSQLQTQVS
     DTSVVLSMDN NRNLDLDSII AEVKAQYEDI ANRSRAEAES WYQTKYEELQ VTAGRHGDDL
     RNTKQEISEM NRMIQRLRAE IDSVKKQCSS LQTAIADAEQ RGELALKDAR AKLVDLEEAL
     QKAKQDMARL LREYQELMNI KLALDVEIAT YRKLLEGEEC RLSGEGVSPV NISVVTSTLS
     SGYGSGSSIG GGSLGLGGGS GYSFTTSGGH SLGAGLGGSG FSATGNRGLG GSGSSVKFVS
     TTSSSRKSYK H
//