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Database: UniProt
Entry: G1S8X0_NOMLE
LinkDB: G1S8X0_NOMLE
Original site: G1S8X0_NOMLE 
ID   G1S8X0_NOMLE            Unreviewed;      1679 AA.
AC   G1S8X0;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   28-MAR-2018, entry version 43.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1S {ECO:0000313|Ensembl:ENSNLEP00000021959};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates
OS   leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hylobatidae; Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000021959};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000021959}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000021959}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in
CC       opposite effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; ADFV01023221; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01023222; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01023223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01023224; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01023225; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01023226; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01023227; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 61853.ENSNLEP00000021959; -.
DR   Ensembl; ENSNLET00000023071; ENSNLEP00000021959; ENSNLEG00000018075.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; G1S8X0; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000001073; Chromosome 9.
DR   GO; GO:0031674; C:I band; IEA:Ensembl.
DR   GO; GO:0030315; C:T-tubule; IEA:Ensembl.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:Ensembl.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0006936; P:muscle contraction; IEA:Ensembl.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005450; VDCC_L_a1ssu.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF190; PTHR10037:SF190; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 5.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   PRINTS; PR01634; LVDCCALPHA1S.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001073};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     35     56       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     68     89       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    140    162       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    222    243       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    255    277       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    377    394       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    414    432       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    506    525       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    578    605       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    739    761       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    781    799       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    973    999       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1053   1071       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1083   1101       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1191   1209       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1282   1306       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1440   1473       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
SQ   SEQUENCE   1679 AA;  191058 MW;  B9A8079D4F4888AA CRC64;
     ILLTIFANCV ALAVYLPMPE DDNNSLNLSL EKLEYFFLIV FSIEAAMKII AYGFLFHQDA
     YLRSGWNVLD FTIVFLGVFT VILEQVNVIQ SHTAPMSSKG AGLDVKALRA FRVLRPLRLV
     SGVPSLQVVL NSIFKAMLPL FHIALLVLFM VIIYAIIGLE LFKGKMHKTC YFTGTDIVAT
     VENEEPSPCA RTGSGRRCTI NGSECRGGWP GPNHGITHFD NFGFSMLTVY QCITMEGWTD
     VLYWVNDAIG NEWPWIYFVT LILLGSFFIL NLVLGVLSGE FTKEREKAKS RGTFQKLREK
     QQLDEDLRGY MSWITQGEVM DVEDFREGKL SLDEGGSDTE SLYEIAGLNK IIQFIRHWRQ
     WNRIFRWKCH DIVKSKVFYW LVILIVALNT LSIASEHHNQ PLWLTRLQDI ANRVLLSLFT
     VEMLIKMYGL GLRQYFMSIF NRFDCFVVCS GILEILLVES GAMTPLGISV LRCIRLLRIF
     KITKYWTSLS NLVASLLNSI RSIASLLLLL FLFIVIFALL GMQLFGGRYD FEDTEVRRSN
     FDNFPQALIS VFQVLTGEDW TSMMYNGIMA YGGPSYPGML VCIYFIILFV CGNYILLNVF
     LAIAVDNLAE AESLTSAQKA KAEERKRRKM SKGLPEKSEE EKSTMAKKLE QKPKGEGIPT
     TAKLKIDEFE SNVNEVKDPY PSADFPGDDE EDEPEIPLSP RPRPLAELQL KEKAVPIPEA
     SSFFIFSPTN KIRVLCHRIV NATWFTNFIL LFILLSSAAL AAEDPIRADS MRNQILKHFD
     IGFTSVFTVE IMTTYGAFLH KGSFCRNYFN MLDLLVVAVS LISMGLESSA ISVVKILRVL
     RVLRPLRAIN RAKGLKVREE PTFLSCFHDN MPPSLPPSSW LQGKFFRCTD LSKMTEEECR
     GYYYVYKDGD PTQIELRHRE WVHSDFHFDN VLSAMMSLFT VSTFEGWPQL LYKAIDSNEE
     DMGPIYNNRV EMAIFFIIYI ILIAFFMMNI FVGFVIVTFQ EQGETEYKNC ELNKNQRQCV
     QYALKARPLR CYIPKNPYQY QVWYIVTSSY FEYLMFALIM LNTICLGMQH YNQSEQMNHI
     SDILNVAFTI IFTLEMILKL MAFKARGYFG DPWNVFDFLI VIGSIIDVIL SEIDVSIRLT
     SGAAAPQDPD ESARISSAFF RLFRVMRLIK LLSRAEGVRT LLWTFIKSFQ ALPYVALLIV
     MLFFIYAVIG MQMFGKIALV DGTQINRNNN FQTFPQAVLL LFRCATGEAW QEILLACSYG
     KLCDPESDYA PGEEYTCGTN FAYYYFISFY MLCAFLVINL FVAVIMDNFD YLTRDWSILG
     PHHLDEFKAI WAEYDPEAKG RIKHLDVVTL LRRIQPPLGF GKFCPHRVAC KRLVGMNMPL
     NSDGTVTFNA TLFALVRTAL KIKTEGNFEQ ANEELRAIIK KIWKRTSMKL LDQVIPPIGD
     DEVTVGKFYA TFLIQEHFRK FMKRQEEYYG YRPKKDVVQI QVSPIQVHLA AEEELERAMV
     EAAMEEGIFR RTGGLFGQVD NFLERTNSLP PVMANQRPLQ FAEIEMEEME SPIIQGASAN
     PNAWASPQML AVGHSHHSPL SSSGDPMCGR DGEAGFQRLG GCSWALEDEQ NAERVEGATE
     QRSGVRNALD SFLLESQGWL GHSGGSVSPR VTATTLGWPC TGSEGKGCLG PERQGCQES
//
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