ID G1SDC0_RABIT Unreviewed; 1309 AA.
AC G1SDC0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Par-3 family cell polarity regulator {ECO:0000313|Ensembl:ENSOCUP00000000400.4};
GN Name=PARD3 {ECO:0000313|Ensembl:ENSOCUP00000000400.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000000400.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000000400.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000000400.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000000400.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Endomembrane system
CC {ECO:0000256|ARBA:ARBA00004308}.
CC -!- SIMILARITY: Belongs to the PAR3 family.
CC {ECO:0000256|ARBA:ARBA00005358}.
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DR PaxDb; 9986-ENSOCUP00000000400; -.
DR Ensembl; ENSOCUT00000000457.4; ENSOCUP00000000400.4; ENSOCUG00000000455.4.
DR eggNOG; KOG3528; Eukaryota.
DR GeneTree; ENSGT00950000183214; -.
DR HOGENOM; CLU_006629_0_0_1; -.
DR TreeFam; TF323729; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000000455; Expressed in ovary and 16 other cell types or tissues.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 3.
DR Gene3D; 2.30.42.10; -; 3.
DR InterPro; IPR021922; Par3/HAL_N.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR16484:SF10; PARTITIONING DEFECTIVE 3 HOMOLOG; 1.
DR PANTHER; PTHR16484; PARTITIONING DEFECTIVE 3 RELATED; 1.
DR Pfam; PF12053; Par3_HAL_N_term; 1.
DR Pfam; PF00595; PDZ; 3.
DR SMART; SM00228; PDZ; 3.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR PROSITE; PS50106; PDZ; 3.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022427};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 264..340
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 431..516
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 560..635
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 74..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 150..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 230..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 370..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 827..855
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 899..1043
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1098..1231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1248..1309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..413
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 830..844
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 926..945
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 946..1043
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1115..1144
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1145..1169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1181..1212
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1251..1266
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1309 AA; 144622 MW; 39B6CC9C078BFDA9 CRC64;
MALGSSWKEG VAERGQKRGC CWPGRVPLGQ AGNQDPSYWI QVHRLEHGDG GILDLDDVLC
DVVDDKDRLV AVFDEQDPHH GGDGTSASST GTQSPELFGG ELGPSGASAF QPYQAPSEIE
VTPSVLRTNM PLHVRRSSDP ALVGLSTSLS DNHFSSEEPS RKNPTRWSTT AGFLKQSPSG
GPNTCDRKKD ENYRSLPRDT SSWSQFQRDN ARSSLSASHP LVDKWLEKQE QEEDGVEEDS
SRVEPLGHAD TGSENIPSFS LDDMVKLVQV SNDGGPLGIH VVPFSARGGR TLGLLVKRLE
KGGKAEHEGL FHENDCIVRI NDGDLRNRRF EQAQHMFRHA MRTPVIWFHV VPAAKKEQYE
LLSQSESRQA CASRLSPDSP GAADGRAGGG GLGLPGPARA PRPSEPADAH PRLPPSAPHA
YSAKKVGRRL HIQLKKGSEG LGFSITSRDV TIGGSAPIYV KNILPRGAAI QDGRLKAGDR
LVEVNGVDIA GKSQEEVVSL LRSTKMEGTV SLLVFRQEDA FHPRELNAEP RQTQIPKETK
AEDEDIVLTP DGTREFLTFE VPLNDSGSAG LGVSVKGNRS KENHADLGIF VKSIINGGAA
SKDGRLRVND QLIAVNGESL LGRTNQDAMD ALRRSMSTEG NKRGMIQLIV ARRVSKGGQL
KSPGSPAGPE LPIETVLEDS ERRISHSLYS GIEELEESPA RSAALGRIVG KFQLSPTVNM
SHDDSVIIED DRLPVLPPQL SDQSSSSSHD DMGFVTTEVA TWAKAAISDS ADCSLSPDVD
PVLAFQREGF GRQSMSEKRT KQFSDASQLD FVKTRKSKSM DLGIADETKL NTVDDQTSGS
PSRDVGPSLG LKKSSSLESL QTAVAEATLN GDIPFHRPRP RIIRGRGCNE SFRAAIDKSY
DKPVADDDDE GMETLEEDTE ESSRSGRESV STASDQPSHS LERQTNGNQE RGDKTDRKRD
KTGKEKKKDR DKEKDKMKAK KGMLKGLGDM FRFGKHRKDD KIEKTGRIKM QETFTSEEER
TRMKQERERI QAKTREFRER QARERDYAEI QDFHRTFGCG EESMYGGLSP YEGSLALNAR
PQSPREGHLM DALYAQVKKP RNPKPSPVDS RAAPSNHDRI QRLRQEFQQA KQEEDAEDRR
RTYSFEQPWP SSRPAAQSGR HSVSVEVQVQ RQRQEERDSF QQAQRQYSSL PRQSRKNASC
VSQDSWEQSC PPGEAFQSAK DSPRYSSYQG SKNGYLGGHG FNARVMLETQ ELLRQEQRRK
EQQMKKLPAP EGAYAPAKGP FRQDVPPSPS QVARLSRLQT PEKGRPFYS
//
