ID G1SDQ5_RABIT Unreviewed; 964 AA.
AC G1SDQ5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE SubName: Full=VPS50 subunit of EARP/GARPII complex {ECO:0000313|Ensembl:ENSOCUP00000000546.2};
GN Name=VPS50 {ECO:0000313|Ensembl:ENSOCUP00000000546.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000000546.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000000546.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000000546.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000000546.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000000546.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR EMBL; AAGW02035394; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02035395; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02035396; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02035397; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02035398; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02035399; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008259945.1; XM_008261723.2.
DR AlphaFoldDB; G1SDQ5; -.
DR SMR; G1SDQ5; -.
DR STRING; 9986.ENSOCUP00000000546; -.
DR PaxDb; 9986-ENSOCUP00000000546; -.
DR Ensembl; ENSOCUT00000000629.4; ENSOCUP00000000546.2; ENSOCUG00000000625.4.
DR GeneID; 100353605; -.
DR KEGG; ocu:100353605; -.
DR CTD; 55610; -.
DR eggNOG; KOG2939; Eukaryota.
DR GeneTree; ENSGT00390000003442; -.
DR HOGENOM; CLU_009513_1_0_1; -.
DR InParanoid; G1SDQ5; -.
DR OMA; KIPAMGF; -.
DR OrthoDB; 7240at2759; -.
DR Proteomes; UP000001811; Chromosome 10.
DR Bgee; ENSOCUG00000000625; Expressed in prefrontal cortex and 15 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:1990745; C:EARP complex; IEA:Ensembl.
DR GO; GO:0000149; F:SNARE binding; IEA:Ensembl.
DR GO; GO:0032456; P:endocytic recycling; IEA:Ensembl.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro.
DR InterPro; IPR019514; Syndetin_C.
DR InterPro; IPR040047; VPS50.
DR InterPro; IPR019515; VPS54_N.
DR PANTHER; PTHR13258:SF0; SYNDETIN; 1.
DR PANTHER; PTHR13258; UNCHARACTERIZED; 1.
DR Pfam; PF10474; Syndetin_C; 1.
DR Pfam; PF10475; Vps54_N; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 54..345
FT /note="Vacuolar protein sorting-associated protein 54 N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF10475"
FT DOMAIN 723..957
FT /note="Syndetin C-terminal"
FT /evidence="ECO:0000259|Pfam:PF10474"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 542..564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 216..243
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..564
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 964 AA; 111089 MW; E5A18A12ECE622D3 CRC64;
MQKIKSLMTR QGLKSPPESL SDLGAIENLR VPGKEEFREL REQPSDPQAE QELINSIEQV
YFSADSFDIV KYELEKLPPV LNLQELEEYR DKLKQQQAAV SKKVADLILE KQPAYVKELE
RVTSLQTGLQ LAAVICTNGR RHLNIAKEGF TQASLGLLAN QRKRQLLIGL LKSLRTIKTL
QRTDVRLSEM LEEEDYPGAI QLCLECQNAA STFKHYSCIS ELNSKLQDTL EQIEEQLDVA
LSKICKNFDI NHYTKVQQAY RLLGKTQTAM DQLHMHFTQA IHNTVFQVVL GYVELCACNT
DTKFQKLQYK DLCTHVIPDS YIPCLADLCK ALWEVMLSYY RTMEWHEKHD GADTAAAAEG
SNIMGTEETN FDRGYIKKKL EHGLTRIWQD VQLKVKTYLL GTDLSIFKYD DFIFVLDIIS
RLMQVGEEFC GSKSEVLQES IRKQSVNYFK NYHRTRLDEL RMFLENETWE LCPVKSNFSI
LQLHEFKFLE QSRSPSVSPS KQPVSTSSKS VTLFEQYCSG GNPFEIQANH KDEETEDVLA
SNGYESDEQE KSAYQEYDSD SDVPEELKRD YVDEQTGDAP VKSVSRETLK SRKKSDYSLN
KVNAPILTNT TLNVIRLVGK YMQMMNILKP IAFDVIHFMS QLFDYYLYAI YTFFGRNDSL
ESTGLGLSSS RLRTTLNRIQ ESLIDLEVSA DPAATLTAAE ERREKVPSPH LSHLVVLTAG
DTLYGLAERV VATESLVFLA EQFEFLQPHL DAVMPAVKKP FLQQFYSQTV STASELRKPI
YWIVAGKAID YEQMLLLMAN VKWDVKEIMS QHNIYVDALL KEFEQFNRRL NEVSKRVRIP
LPVSNILWEH CIRLANRTIV EGYANVKKCS NEGRALMQLD FQQFLMKLEK LTDIRPIPDK
EFVETYIKAY YLTENDMERW IKEHREYSTK QLTNLVNVCL GSHINKKARQ KLLAAIDDLD
RPRR
//