ID G1SEG3_RABIT Unreviewed; 1010 AA.
AC G1SEG3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Sortilin related VPS10 domain containing receptor 1 {ECO:0000313|Ensembl:ENSOCUP00000000842.4};
GN Name=SORCS1 {ECO:0000313|Ensembl:ENSOCUP00000000842.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000000842.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000000842.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000000842.4,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000000842.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000000842.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC subfamily. {ECO:0000256|ARBA:ARBA00010818}.
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DR EMBL; AAGW02051392; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02051393; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02051394; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02051395; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02051396; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02051397; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02051398; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02051399; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02051400; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02051401; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1SEG3; -.
DR Ensembl; ENSOCUT00000000974.4; ENSOCUP00000000842.4; ENSOCUG00000000972.4.
DR eggNOG; KOG3511; Eukaryota.
DR GeneTree; ENSGT01030000234563; -.
DR HOGENOM; CLU_010702_0_0_1; -.
DR Proteomes; UP000001811; Chromosome 18.
DR Bgee; ENSOCUG00000000972; Expressed in frontal cortex and 11 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 3.30.60.270; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF8; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS1; 1.
DR Pfam; PF00801; PKD; 1.
DR Pfam; PF15902; Sortilin-Vps10; 1.
DR Pfam; PF15901; Sortilin_C; 1.
DR SMART; SM00602; VPS10; 1.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR SUPFAM; SSF49299; PKD domain; 2.
DR PROSITE; PS50093; PKD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 930..948
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 664..708
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT REGION 970..1010
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1010 AA; 114012 MW; 28D215B6452504E4 CRC64;
ANAVTIHSII DCNCLRLTMI FSFCLQVILI LTKLYDYNLG SITESSLWRS TDYGTTYEKL
NDKVGLKTIL SYLYVCPTNK RKIMLLTDPE IESSLLISSD EGATYQKYRL NFYIQSLLFH
PKQEDWILAY SQDQKLYSSA EFGRRWQLIQ EGVVPNRFYW SVMASNKEPD LVHLEARTVD
GHSQYLTCRM QNCTETNKNK PFPGYIDPDS LIVQDDYVFV QLTSGGRPHY YVSYRRNAFA
QMKLPKYALP KDMHVISTDE NQVFAAVQEW NQNDTYNLYI SDTRGVYFTL ALENVQSSRG
PEGNVMIDLY EVAGIKGMFL ANKKIDNQVK TFITYNKGRD WRLLQAPDTD LRGDPVHCLL
PYCSLHLHLK VSENPYTSGI IASRDTAPSI IVASGNIGSE LSDSDISMFV SSDAGNTWRQ
IFEEEHSVLY LDQGGVLVAM KHTSLPIRHL WLSFDEGRSW SKYSFTSIPL FVDGVLGEPG
EETLIMTVFG HFSHRSEWQL VKVDYKSIFD RRCAEEDYRP WQLHREACIM EQKGYIEAKS
ERKCMHGKYA GAMESEPSCT YPMEHSNGQC LPAFWFNPSS LSKDCSVGKS YLNSTGYRKV
VSNNCTDGVR EQYTAKPQKC PGKAPRGLRI ITADGKLTAE QGHNVTLMVQ LEEGDVQRTL
IQVDFGDGIA VSYVNLSSME DGIKHVYQNV GIFRVTVQVD NSLGSDSAVL YLHVTCPLEH
VHLSLPFVTT KNKEVNATAV LWPSQVGTLT YVWWYGNNTE PLITLEGSIS FKFTSEGMNT
ITVQVSAGNA ILQDTKTIAV YEEFRSLRLS FSPNLDDYNP DIPEWRRDIS RVIKKSLVEA
TGIPGQHILV AVLPGLPTAA ELFVLPYQDP AGESRRSPEE LEQVSELLIH KLNQNSVHFE
LKPGVQVLVH AAHLTAAPLV DLTPAHSGSA MLMLLSVVFV GLAVFVIYKF KRKIPGINVY
AQMQNEKEQE MISPVSHTES RPNIPPTELR RPGQLIDEKV ESQLIGNDSQ
//
