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Database: UniProt
Entry: G1SFB0_RABIT
LinkDB: G1SFB0_RABIT
Original site: G1SFB0_RABIT 
ID   G1SFB0_RABIT            Unreviewed;      1775 AA.
AC   G1SFB0;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 2.
DT   25-OCT-2017, entry version 45.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN11A {ECO:0000313|Ensembl:ENSOCUP00000001187};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000001187, ECO:0000313|Proteomes:UP000001811};
RN   [1] {ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke inbred {ECO:0000313|Proteomes:UP000001811};
RG   The Genome Sequencing Platform;
RG   The Genome Assembly Team;
RA   Lindblad-Toh K., Chang J.L., Gnerre S., Clamp M., Lander E.S.;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke inbred {ECO:0000313|Proteomes:UP000001811};
RG   The Genome Sequencing Platform;
RG   The Assembly Computation and Development Core Team;
RA   Di Palma F., Heiman D., Young S., Gnerre S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "Version 2 of The Genome Sequence of Oryctolagus cuniculus (European
RT   rabbit).";
RL   Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSOCUP00000001187}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000001187};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [4] {ECO:0000313|Ensembl:ENSOCUP00000001187}
RP   IDENTIFICATION.
RC   STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000001187};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOCUP00000001187}.
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DR   STRING; 9986.ENSOCUP00000001187; -.
DR   Ensembl; ENSOCUT00000001379; ENSOCUP00000001187; ENSOCUG00000001376.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; G1SFB0; -.
DR   OMA; CYQIVKH; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0044299; C:C-fiber; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR   GO; GO:0051930; P:regulation of sensory perception of pain; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028821; Na_channel_a11su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   PANTHER; PTHR10037:SF210; PTHR10037:SF210; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001811};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    113    131       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    137    156       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    168    189       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    201    219       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    258    276       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    377    397       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    613    634       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    646    664       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    702    726       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    785    810       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1049   1072       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1109   1132       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1158   1184       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1279   1302       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1352   1374       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1394   1413       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1425   1443       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1480   1508       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1528   1547       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1568   1594       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      137    414       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      583    817       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      828   1043       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1047   1311       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1360   1604       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      408    439       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1775 AA;  201860 MW;  C3E31226896C1AB4 CRC64;
     MKMDDRCYPV IFPDAQNFRP FTSDSLAAIE KRLIIQKEQS KSRDKTGGAG GEPQPRPQLD
     LKASRKLPKL YGNIPPELIG KPLEDLDPFY RNHKTFMVLN KKRTIYRFSA KRALFIFGPF
     SSIRSLAIRI SVHSYPFMLI ISTVVINCVF MARGRVKDSN STVPDTAEYV FTGIYIFEAL
     IKILARGFIL DEFSFLRDPW NWLDSIVIGT AIVSYFPNIN INLLSLRTFR VFRALKAISV
     VSGLKVIVGA LLRSVKKLVD VMILTLFCLS IFALVGQQLF MGSLSLKCVD NECVNHSHHL
     AADKCFEKEE NSKEFRMCGT WMQDRACSKN YTCRLTKFNP DYNYTNFDNF GWSFLAMFRL
     MTQDSWEKLY QQTLRTAGLY SVFFFVVVIF LGSFYLINLT LAVVTMAYEE QNRNVAAETE
     AKEKMFQEAQ RLLKEEKENL VAMGIDRSSL NSLEASSFSS KKRKLFGSKK RKSFFMREPK
     NDQAPGSDSD DDSSQKPHLL EQTKRLSQNL SVDHFDEHGD PLQRQRALSA VSILTITMHE
     QEKAQEPCLP CGKNLASKYL VWNCCPLWVC IKKALRAVVT DPFTELAVTL CIIVNTVFLA
     LEHHNMDKDF KAILSTGNLV FTAIFIAEMC LKIMALDPYY YFRQRWNIFD CVVALLSLVD
     VIYVRHNLPY LRPLRVLRVF KLAKSWPTLN TLIKIIGHSV GAFGNLTVVL AIVVFIFSVV
     GMQLFGSKFC SVKSRKLCNP GESCARRWHM GDFYHSFLVV FRILCGEWIE NMWECMQEMD
     TEAPLCVIIF VLIMVIGKLV VLNLFIALLL NSFSSEERGG SAEEETRKTK VQLALDRVRK
     AFARLVLLAG RFCRRRCGKR SSPKQTDGPA GRDLIALASG KRGGPEPREA VGAPASGPRL
     LSIGHGRAWL APLAEEDDTT SLGEDDPAAA TQQMGEGQAC EPHQETEKPS SPGVESLEVD
     VFPEDVCLTS QTPQKKADSS SVLSECSTID LQEAFRWLAE TAPRKQPDRC LPKGLSSCCP
     CCSVDKRKSP WATWWNLRKT CYQIVKHSWF ESFIIFVILL SSGTLVFEDV YLKYQPNIER
     LLNCTDNIFT FIFILEMGLK WVAFGFRKYF TSAWCWLDFV IVIVSVISLI NLKSLKSFRT
     LRALRPLRAL SQFEGMKVVV NALIGAIPAI LNVLLVCLIF WLIFCIVGVN FFSGKFGKCI
     NKTDPNLFTN HTIITYRNQC QTDNFSWVNP EVNFDNVGQA YLALLQVATY KGWMEIMYAA
     VDSRDKDVQP VFEANSCMYI YFIIFIIFGS FFSLNLFIGV IIDNFNQQQR KLGGQDIFMT
     EEQKKYYNAM KKLGTKKPQK PIPRPLNKCQ GLVFDLVTSQ VFDIIIILLI VLNMVSMMME
     TTEQSRAMTA VLDYLNVAFV VIFTAECLVK VFALRQYYFT NGWNLFDGVV VVLSIVSTMV
     SALENQKHIP FPPTLFRIVR LARIGRVLRL VRAARGIRTL LFALMMSLPS LFNIGLLLFL
     VMFIYAILGM NCFSDVSPQP GVDDIFNFRT FVRSMLCLFQ ITTSAGWDSL LRPMLKAENA
     SRNRYLPAIA IAYFVSYIII SFLIVVNMYI AVILENFNTA TEESEDPLGE DDFEIFYEVW
     EKFDPEATQF IAYSALSDFA DALPEPLRVA KPNKFQFLVM DLPMVSGDRL HCLDILFAFT
     TRVLGDSSCP DSMKAMMEEK FMEANPFKKL YEPIVTTTKR KEEERGAAVI QKAFRKYLTK
     MTKCPLEDRP PPPLQMLCNG DLPSAEVAKG KAHYD
//
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