ID G1SFD3_RABIT Unreviewed; 1210 AA.
AC G1SFD3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 24-JAN-2024, entry version 68.
DE SubName: Full=Membrane associated guanylate kinase, WW and PDZ domain containing 2 {ECO:0000313|Ensembl:ENSOCUP00000001212.3};
GN Name=MAGI2 {ECO:0000313|Ensembl:ENSOCUP00000001212.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000001212.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000001212.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000001212.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000001212.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000001212.3};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR EMBL; AAGW02038579; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02038580; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02038581; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02038582; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02038583; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02038584; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02038585; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02038586; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02038587; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02038588; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1SFD3; -.
DR Ensembl; ENSOCUT00000001407.4; ENSOCUP00000001212.3; ENSOCUG00000001407.4.
DR eggNOG; KOG3209; Eukaryota.
DR GeneTree; ENSGT00940000155057; -.
DR HOGENOM; CLU_004562_1_0_1; -.
DR TreeFam; TF316816; -.
DR Proteomes; UP000001811; Chromosome 7.
DR Bgee; ENSOCUG00000001407; Expressed in frontal cortex and 13 other cell types or tissues.
DR GO; GO:0005923; C:bicellular tight junction; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0014069; C:postsynaptic density; ISS:UniProtKB.
DR GO; GO:0036057; C:slit diaphragm; ISS:UniProtKB.
DR GO; GO:0045202; C:synapse; ISS:UniProtKB.
DR GO; GO:0031697; F:beta-1 adrenergic receptor binding; ISS:UniProtKB.
DR GO; GO:0019902; F:phosphatase binding; ISS:UniProtKB.
DR GO; GO:0030159; F:signaling receptor complex adaptor activity; ISS:UniProtKB.
DR GO; GO:0046332; F:SMAD binding; ISS:UniProtKB.
DR GO; GO:0070699; F:type II activin receptor binding; ISS:UniProtKB.
DR GO; GO:0032926; P:negative regulation of activin receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0030336; P:negative regulation of cell migration; ISS:UniProtKB.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0051898; P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; ISS:UniProtKB.
DR GO; GO:0072015; P:podocyte development; ISS:UniProtKB.
DR GO; GO:0032516; P:positive regulation of phosphoprotein phosphatase activity; ISS:UniProtKB.
DR GO; GO:0002092; P:positive regulation of receptor internalization; ISS:UniProtKB.
DR GO; GO:0043113; P:receptor clustering; ISS:UniProtKB.
DR GO; GO:0060395; P:SMAD protein signal transduction; ISS:UniProtKB.
DR CDD; cd00992; PDZ_signaling; 4.
DR CDD; cd00201; WW; 2.
DR Gene3D; 2.20.70.10; -; 2.
DR Gene3D; 2.30.42.10; -; 5.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR10316; MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED; 1.
DR PANTHER; PTHR10316:SF27; MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF16663; MAGI_u1; 1.
DR Pfam; PF00595; PDZ; 4.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00228; PDZ; 4.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 4.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS50106; PDZ; 4.
DR PROSITE; PS01159; WW_DOMAIN_1; 2.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 139..172
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 185..218
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 264..333
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 443..506
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 602..684
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 904..986
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 1..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 528..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 693..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 770..873
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1018..1210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..138
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..551
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 698..737
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 770..799
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 800..814
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 826..842
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1042..1080
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1210 AA; 131334 MW; 256381BB27B4A776 CRC64;
MELEKSGALL ESGTYEDNYY GTPKPPAEPA PLLLNVTDQI LPGATPSAEG KRKRNKSVSN
MEKASVEPPE EEEEERPVVN GNGVVVTPES SEQEDKSAGA SGETPSQPYP APVYSQPEEL
KEHMEDTKPT KPEESEDSDP LPDNWEMAYT EKGEVYFIDH NTKTTSWLDP RLAKKAKPPE
ECKGNELPYG WEKIDDPIYG TYYVDHINRR TQFENPVLEA KRKLQQQHNM PHTELGPKPL
QAPGFREKPL FTRDASQLKG TFLSTTLKKS NMGFGFTIIG GDEPDEFLQV KSVIPDGPAA
QDGKMETGDV IVYINEVCVL GHTHADVVKL FQSVPIGQSV NLVLCRGYPL PFDPEDPANS
LVPPLAIMER PPPVMVNGRH NYETYLEYIS RTSQSVPDIT DRPPQSLHSM PADGQLDGTY
PPPVHDDNVS MASSGATQAE LMTLTIVKGA QGFGFTIADS PTGQRVKQIL DIQGCPGLCE
GDLIVEINQQ NVQNLSHTEV VDILKDCPVG SETSLIIHRG GFFSPWKTPK PIPDRWENQG
SPQTSLSAPA GPQNLPFPPA LHRSSFPDSA EAFDPRKPDP YELYEKSRAI YESRRPDYKE
LDVHLRRMES GFGFRILGGD EPGQPILIGA VIAMGSADRD GRLHPGDELV YVDGIPVAGK
THRYVIDLMH HAARNGQVNL TVRRKVLCGG EPCPENGRSP GSVSTHHSSP RSDYTTYANS
NHAASSSNAS PPEGFASHSL QTSDVVIHRK ENEGFGFVII SSLNRPESGS TIKLNSPASA
PSSEKQSPSA QQHSPSAQPS PATPNSPVAQ PAPPQPLQLQ GHESSYRSEV KARQDVKPDI
RQPPFTDYRQ PPLDYRQPPG GDFQQPPPVE YRQPPLLDYR QHSPDTRQYP LSDYRQPQDF
DYFTVDMEKG AKGFGFSIRG GREYKMDLYV LRLAEDGPAI RNGRMRVGDQ IIEINGESTR
DMTHARAIEL IKSGGRRVRL LLKRGTGQVP EYDEPSAWSA AAAAAPGLPQ VGVSLEDILS
PFSPSHPAPP SDPSLQIGPD PTWDIKREHD VRKPKELSAG GQKKQRLGEQ RERSASPQRA
ARPRLEEAPG GQGRPEAGRP ASEARAPGPA AADAADATRA GGQEGPRAAA APEPGRREGP
GAAAAFGGVG GVSAREAEAR AGARAGSRPG PRPPGVAPAR KASVAPGPWR VPGSDKLPGV
LKPGASAAGR
//