ID G1SFQ4_RABIT Unreviewed; 1212 AA.
AC G1SFQ4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Integrin subunit alpha M {ECO:0000313|Ensembl:ENSOCUP00000001364.4};
GN Name=ITGAM {ECO:0000313|Ensembl:ENSOCUP00000001364.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000001364.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000001364.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000001364.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000001364.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; G1SFQ4; -.
DR PaxDb; 9986-ENSOCUP00000001364; -.
DR Ensembl; ENSOCUT00000001589.4; ENSOCUP00000001364.4; ENSOCUG00000001587.4.
DR eggNOG; KOG3637; Eukaryota.
DR GeneTree; ENSGT00940000161282; -.
DR HOGENOM; CLU_004111_3_0_1; -.
DR TreeFam; TF105391; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000001587; Expressed in blood and 14 other cell types or tissues.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd01469; vWA_integrins_alpha_subunit; 1.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR048633; ITGAX-like_Ig_3.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF130; INTEGRIN ALPHA-M; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF00357; Integrin_alpha; 1.
DR Pfam; PF21520; ITGAX-like_Ig_3; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 5.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 18..38
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT TRANSMEM 1162..1184
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 75..132
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 207..385
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 500..560
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 564..622
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 627..687
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 1212 AA; 133628 MW; 77B3C1AFD788B6A3 CRC64;
MAWCSQGLRP LPLGLCRLLL PTSLFLVCLA LVASLKWLSG AYDLKTLTPS RPLALPAMTY
RILLLTAVAL CHGFNLETEN TMTFSRNEKG FGQSVVQFEG SRVVVGAPQE ITAPNQTGGL
YQCDYSSNSC DPIQLQVPPE AVNMSLGLSL AASTSPFQLL ACGPTMHQFC KENTYVNGLC
FLFGSNLLQS PQRVPETLRG CPQQESDIAF LIDGSGSIDS TDFQRMKEFV STVMEQFTKS
NSLFALMQYS EEFRTHFTFS DFKRNPNPRA LVKPIRQLLG RTHTATGILK VVTELFHSSS
GARANARKVL VVITDGEKFG DTLEYEDVIP RAEREGVIRY VVGVGDAFNS EQSRQELNTI
ASKPSREHVF RVNNFEALNT IRNQLQEKIF AIEGTQSGST SSFEHEMSQE GFSAAITSSG
PLLGSVGSFD WAGGAFLHTS KSAVTFINTT RVDSDMNDAY LGYASAVILR NRVKSIVLGA
PRYQHIGLVV MFRQSARVWE VNGEIKGSQI GSYFGSSLCS VDVDRDGSTD LVLIGAPHYY
EQTRGGQVSV CPLPRGQRAR WQCERVLSGE QGHPWGRFGA ALTVLGDVNG DKLADVAIGA
PGEQENRGAV YLFHGVPGFS ISSSHSQRIA GAQLSPRLQY FGQALSGGQD LTQDGLVDLS
VGAKGQVLLL RSQPVLRVEA SMEFTPREVA RSVFECREQA ARVKPAGEVR VCLQVRKSTR
DRLREGDIQS TITYDLALDA GRQYPRAIFD RTKNNTGRHT QTLGLTPKCE TLKLSLPDCV
EDSVGPIVLR LNFSLVGKPL PTFGNLRPVL AADAQTLFMG MFPFEKNCGS DSICQDDLSV
TFSLNLDTVV VGSPQDFNVT LTVRNEGEDS YRTQVTFDPV GLSYRKVSEV QNQRSQRSWR
LNCESIPSSK DSLTLKNTSC SISHPIFPGN SEVTFNITFY VESDAYLGSK LLLKARVTSE
NNMPSTSKSE FQMELPVKYA VYLVVTSGEV STKYLNFTAS EKSTRVLQHE YQFNNLGQRR
LPISVVFWVP VRLQEKTVWD DPQAIFSLNL SSGCHSEERL PPRSDFLAQL NKSPVVNCSI
AVCRRIQCDI PSLSHREQFN VTLQGNLSFD WYIKTAHNHL LLVSAAEILF NQSAFTLLPG
QDAFVRAQTE TKVELYQVHD PVPLIVGSSI GGLVLLALIT AGLYKLGFFK RQYKDMMSEA
APQEAPQEAP PQ
//
