ID G1SG77_RABIT Unreviewed; 525 AA.
AC G1SG77;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Ceramide kinase {ECO:0000313|Ensembl:ENSOCUP00000001572.3};
GN Name=CERK {ECO:0000313|Ensembl:ENSOCUP00000001572.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000001572.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000001572.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000001572.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000001572.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G1SG77; -.
DR SMR; G1SG77; -.
DR STRING; 9986.ENSOCUP00000001572; -.
DR PaxDb; 9986-ENSOCUP00000001572; -.
DR Ensembl; ENSOCUT00000001828.4; ENSOCUP00000001572.3; ENSOCUG00000001828.4.
DR eggNOG; KOG1115; Eukaryota.
DR GeneTree; ENSGT00940000156976; -.
DR HOGENOM; CLU_013399_2_2_1; -.
DR InParanoid; G1SG77; -.
DR TreeFam; TF314514; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000001828; Expressed in uterus and 15 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0001729; F:ceramide kinase activity; IEA:Ensembl.
DR GO; GO:0000287; F:magnesium ion binding; IEA:Ensembl.
DR GO; GO:0006672; P:ceramide metabolic process; IEA:Ensembl.
DR Gene3D; 2.60.200.40; -; 1.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR045363; CERK_C.
DR InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR PANTHER; PTHR12358:SF25; CERAMIDE KINASE; 1.
DR PANTHER; PTHR12358; SPHINGOSINE KINASE; 1.
DR Pfam; PF19280; CERK_C; 1.
DR Pfam; PF00781; DAGK_cat; 1.
DR SMART; SM00046; DAGKc; 1.
DR SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR PROSITE; PS50146; DAGK; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 127..239
FT /note="DAGKc"
FT /evidence="ECO:0000259|PROSITE:PS50146"
SQ SEQUENCE 525 AA; 59038 MW; 5D0FF842B87E8799 CRC64;
MGAAEPLRSV LWVKRQRCAV SLEPGRALLR WWRSPGPGAG AGAPGADACC VPVSEIITVE
EAEVRGRHHP SGRWQKMEKP HAFTVHCVKR ARQHRWKWAQ VTFWSADEQL CHLWLQTLRE
LLEKLTSRPK HLLVFINPFG GKGQGKRIYE RKVAPLFTLA AISTEVIVTE RANQAQEALY
EMNLDKYDGV VCVGGDGMFS EVLHGLIGRT QRSAGVDQNH PRAALAPIAL RIGIIPAGTP
RPRCSSAYLH MGDSLPMDVS SVHHNSTLLR YWVSLLGYGF YGDIIKDSER KRWMGLIRYD
VAGVKTFLSH HCYEGTVSFL PAQHTVGSPR DGKPCRAGCF VCRQSKQQLE EEQKKALYGL
GDTEEMEEWQ VVCGKFLAIN ATNMSCACPR SPRGLSPAAH LGDGSCDLIL IRKCSRFNFL
RFLVRHRNQD DQFDFTFVEV YRVKRFHFTS KHAEGEDGDL QERAKQRFGP LCSDSPACCR
SAAKSSWNCD GEILHSPAIE VRVHCQLVRL FARGIEEEPK REVHS
//
