ID G1SGX1_RABIT Unreviewed; 977 AA.
AC G1SGX1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Vacuolar protein sorting-associated protein 54 {ECO:0000256|ARBA:ARBA00017665};
GN Name=VPS54 {ECO:0000313|Ensembl:ENSOCUP00000001852.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000001852.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000001852.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000001852.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000001852.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000001852.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network
CC {ECO:0000256|ARBA:ARBA00004601}.
CC -!- SIMILARITY: Belongs to the VPS54 family.
CC {ECO:0000256|ARBA:ARBA00009150}.
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DR EMBL; AAGW02006708; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02006709; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02006710; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02006711; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02006712; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02006713; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008252569.1; XM_008254347.2.
DR AlphaFoldDB; G1SGX1; -.
DR SMR; G1SGX1; -.
DR STRING; 9986.ENSOCUP00000001852; -.
DR PaxDb; 9986-ENSOCUP00000001852; -.
DR Ensembl; ENSOCUT00000002147.4; ENSOCUP00000001852.3; ENSOCUG00000002143.4.
DR GeneID; 100341155; -.
DR KEGG; ocu:100341155; -.
DR CTD; 51542; -.
DR eggNOG; KOG2115; Eukaryota.
DR GeneTree; ENSGT00390000000583; -.
DR HOGENOM; CLU_005185_1_0_1; -.
DR InParanoid; G1SGX1; -.
DR OMA; TQDYKIH; -.
DR OrthoDB; 38119at2759; -.
DR TreeFam; TF313700; -.
DR Proteomes; UP000001811; Chromosome 2.
DR Bgee; ENSOCUG00000002143; Expressed in left lung and 15 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0000938; C:GARP complex; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0005802; C:trans-Golgi network; IEA:Ensembl.
DR GO; GO:0006309; P:apoptotic DNA fragmentation; IEA:Ensembl.
DR GO; GO:0048708; P:astrocyte differentiation; IEA:Ensembl.
DR GO; GO:0071393; P:cellular response to progesterone stimulus; IEA:Ensembl.
DR GO; GO:0010467; P:gene expression; IEA:Ensembl.
DR GO; GO:0048873; P:homeostasis of number of cells within a tissue; IEA:Ensembl.
DR GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0051938; P:L-glutamate import; IEA:Ensembl.
DR GO; GO:0007041; P:lysosomal transport; IEA:Ensembl.
DR GO; GO:0014004; P:microglia differentiation; IEA:Ensembl.
DR GO; GO:0007005; P:mitochondrion organization; IEA:Ensembl.
DR GO; GO:0061744; P:motor behavior; IEA:Ensembl.
DR GO; GO:0097049; P:motor neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0050881; P:musculoskeletal movement; IEA:Ensembl.
DR GO; GO:2000672; P:negative regulation of motor neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0097719; P:neural tissue regeneration; IEA:Ensembl.
DR GO; GO:0060052; P:neurofilament cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0150076; P:neuroinflammatory response; IEA:Ensembl.
DR GO; GO:0007274; P:neuromuscular synaptic transmission; IEA:Ensembl.
DR GO; GO:0048812; P:neuron projection morphogenesis; IEA:Ensembl.
DR GO; GO:0035128; P:post-embryonic forelimb morphogenesis; IEA:Ensembl.
DR GO; GO:0034394; P:protein localization to cell surface; IEA:Ensembl.
DR GO; GO:0045047; P:protein targeting to ER; IEA:Ensembl.
DR GO; GO:0006622; P:protein targeting to lysosome; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0040008; P:regulation of growth; IEA:Ensembl.
DR GO; GO:0022904; P:respiratory electron transport chain; IEA:Ensembl.
DR GO; GO:0046677; P:response to antibiotic; IEA:Ensembl.
DR GO; GO:0051592; P:response to calcium ion; IEA:Ensembl.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:Ensembl.
DR GO; GO:0048630; P:skeletal muscle tissue growth; IEA:Ensembl.
DR GO; GO:0048515; P:spermatid differentiation; IEA:Ensembl.
DR GO; GO:0030149; P:sphingolipid catabolic process; IEA:Ensembl.
DR GO; GO:0006941; P:striated muscle contraction; IEA:Ensembl.
DR GO; GO:0051932; P:synaptic transmission, GABAergic; IEA:Ensembl.
DR GO; GO:0035249; P:synaptic transmission, glutamatergic; IEA:Ensembl.
DR GO; GO:0070493; P:thrombin-activated receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0010992; P:ubiquitin recycling; IEA:Ensembl.
DR GO; GO:0007033; P:vacuole organization; IEA:Ensembl.
DR GO; GO:0090119; P:vesicle-mediated cholesterol transport; IEA:Ensembl.
DR Gene3D; 1.20.1280.130; -; 1.
DR Gene3D; 6.10.250.860; -; 1.
DR InterPro; IPR039745; Vps54.
DR InterPro; IPR012501; Vps54_C.
DR InterPro; IPR019515; VPS54_N.
DR PANTHER; PTHR12965; VACUOLAR PROTEIN SORTING 54; 1.
DR PANTHER; PTHR12965:SF0; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54; 1.
DR Pfam; PF07928; Vps54; 1.
DR Pfam; PF10475; Vps54_N; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 207..355
FT /note="Vacuolar protein sorting-associated protein 54 N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF10475"
FT DOMAIN 737..866
FT /note="Vacuolar protein sorting-associated protein 54 C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF07928"
FT REGION 534..577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..576
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 977 AA; 110369 MW; F9ECC01A8DEF9B34 CRC64;
MASSHSSSPV PQGSSSDIFF KKEVDPSKHI RPVQSLPDVC PKEPTGDSSS LCVAPSLVAD
QHRWTIYHSK VNLPAALNDP RLAKRESDFF TKTWGLDFVD TEVIPSFYLP QISKEHFTIY
QQEISQREKI HERCKTICPP KDTFDRTLLH THDKSRTDLE QVPKIFMKPD FALDDSLTFN
SVLPWSHFNT AGGKGSRDAA SSKLLQEKLS HYLDIVEVNI AHQISLRSEA FFHAMTSQHE
LQDYLKKTSQ AVKMLRDKIA QIDKVMCEGS LHILRLALTR NNCVKVFNKL KLMATVHQTQ
PTVQVLLSTS EFVGALDLIA TTQEVLQQEL QGIHSFRHLG SQLCELEKLI DKMMIAEFST
YSHSDLNRPL EDDCQVLEEE RLVSLVFGLL KQRKLNFLEI YGEEMIITAK NIIKQCVINK
VSQIEEIDTD LVVKLADQMR MLNFPQWFDL LKDIFSKFTI FLQRVKATLN IIHSVVLSVL
DKNQRTRELE EISQQKNVAK DNSLDTEVAY LIHEGMFISD AFSEGELTSI AVDTTSQRNA
SPSSEPCSSD SVSEPECTTD SSSSKEQTSS SATPGGVDIM VSEDMKLTDL ELGKLANNIQ
ELLYNASDIC HDRAVKFLTS RAKDGFLEKL NSTEFITLSR LMEAFILDTE QICGKKSMSL
LGALQSQANK FVNRFHEERK TKLSLLLDNE RWKQADVPAE FQDLVDCISD GKIALPEKKS
GATEERKPAE VLIVEGQQYA VVGTVLLLIR IILEYCQCVD NIPSVTTDML TRLSDLLKYF
NSRSCQLVLG AGALQVVGLK TITTKNLALS SRCLQLIVHY IPVIRAHFEA RLPPKQSNML
RHFDHITKDY HDHIAEISAK LVAIMDSLFD KLLSKYEVKA PVPSACFRNI CKQMAKMHEA
IFDLLPEEQT QMLFLRINAS YKLHLKKQLS HLNVINDGGP QNGLVTADVA FYTGNLQALK
GLKDLDLNMA EIWEQKR
//
