ID G1SH77_RABIT Unreviewed; 3304 AA.
AC G1SH77;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Dynein axonemal heavy chain 17 {ECO:0000313|Ensembl:ENSOCUP00000001972.4};
GN Name=DNAH17 {ECO:0000313|Ensembl:ENSOCUP00000001972.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000001972.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000001972.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000001972.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000001972.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR Ensembl; ENSOCUT00000002286.4; ENSOCUP00000001972.4; ENSOCUG00000002284.4.
DR eggNOG; KOG3595; Eukaryota.
DR GeneTree; ENSGT00940000154076; -.
DR HOGENOM; CLU_000038_1_1_1; -.
DR TreeFam; TF335573; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000002284; Expressed in testis and 5 other cell types or tissues.
DR GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2610; -; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703:SF4; DYNEIN AXONEMAL HEAVY CHAIN 17; 1.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 2.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 87..178
FT /note="Dynein heavy chain tail"
FT /evidence="ECO:0000259|Pfam:PF08385"
FT DOMAIN 553..840
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1057..1144
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 1173..1254
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 1382..1478
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 1679..1771
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 1815..2074
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2087..2422
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 2449..2666
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 2780..2900
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 2932..2983
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 3029..3302
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 208..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2722..2751
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3000..3031
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2096..2130
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2293..2349
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2656..2686
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 25..39
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3304 AA; 371728 MW; 3ED14697A21CFBC5 CRC64;
VTRAVQGPRR GRRQEWGCPG RVEAAGRQRT ERWNAPSERD GDGTVRMGSS RRQSRPGSAS
QARRQPQGAV APLLPSAAPP GRPLTRSLFA VQLVAVLREV KYLNFQQQKE IPQSAENLFA
ENETFRKFVG SLELIVGWYN EIKTTVMEVE FPLIKSELEA IDVKLLSAET TLFWNSEGAG
RGHAPWVTRG VRHVTRVQPL SWQPLQRQGG VSVERMDQPP SSAPPGVCPT GVSLGRHCPP
RELLPEAGAR SAPWGQTRCL SRVPPPCPQT DLEDIPDLIE MREELSTLVV NAIKEAEEYQ
DSIERFSYLW TDDPQEFMRN FLIFGHVPTP EELDTRTDDM VPKAQPTLAQ FQQQIDSYEK
LYEEVSRCEN TRVFHGWLQC DCRPFKQALL NTIKRWSLMF KRHLSSHVVS SLADLEAFMK
VARAGLTKPL KEGDYNGLVE VMGHLMKVKE RQVELPEQWT NTKKLAIQVK QNVAPLQANE
VSILRRRCQQ FELKQHEFRE KFRHEAPFSF KDPEPYKSLN KQQKSIAAME DIMESLCKSG
SLFEVTVPDY KQLKACHREA LLLKELWDMI FTVNTSIDDW KTTKWKDINV EQMDLDCKKF
AKDVRSLDKE MKAWDAFVGL DNTVKNMITS LRAVSELQNP AIRDRHWQQL TQATQVKFEM
SDQTTLADLL QLNLHKYEDE VRNIVDKAVK ESGMEKTLDS TWTTMEFEHE PHPRTGTMML
KSDEVLVETL EDNQVQLQNL MMSKYLSHFL EEVTSWQQKL STADSVISIW FEVQRTWSHL
ESIFIGSEDI RAQLPEDSKR FDDIDLEFKA LMEDAVKTPN VVEATNKPGL YDKLEALKKR
WVPRPAAGGG VARRCWVLGS RCLRPQRRAS LEPAVPVAPC GQSHCRPQVE VWLNRVLDRM
CATLRHEIPE AVVTYEEKPR EQWIFDYPAQ VALTCTQIWW TTEVGMAFAR LEEGYENAIK
DYNKKQISQL NALITLLIGN LNAGDRMKIM TVCTIDVHAR DVVAKMITAK VESSQAFTWQ
SQLRHRWDEE KRHCFANICD AQIQYSYEYL GNTPRLSCGN IYKGLAQTGA WGCFDEFNRI
SVEVLSVIAV QVKCVQDAIR AKKKTFNFLG EMISLIPTVG IFITMNPGYA GRTELPENLK
ALFRCGAQGP GASAGREAGG RPARARGPCV RIHLLPGIVT DDLPVFMGLI GDLFPALDVP
RKRDLNFEKV IKQSVVELRL QAEDSFVLKV VQLEELLQVR HSVFVIGNAG SGKSQVLRSL
NKTYQNLKRK PVAIDLDPKA VTCDELFGII NPATREWKDG LFSTIMRDLA NITHDGPKWI
VLDGDIDPMW IESLNTVMDD NKVLTLASNE RIPLNRTMRL VFEISHLRTA TPATVSRAGI
LYINPITVIQ TILYLLECVI TEKTAPPDSS KELYELYFVF ACLWAFGGAM FQDQLVDYRV
EFSRWWINEF KTIKFPSQGT VFDYYIDPDT KKFLPWTDKV PTFELDPDVP LQASLVHTTE
TTRIRYFMDL LMEKSWPVML VGNAGTGKSV LMGDKLDGLS TDDYLVQAVP FNFYTTSAML
QGVLEKPLEK KSGRNYGPPG TKKLIYFIDD MNMPEVDKYG TAAPHTLIRQ HMDHGHWVRV
WGGGGRPEAG PGTCLTGARA RSGQRHFCVF AVSFPGQEAL TTIYSTILTQ TRASVPPPAL
HQKVTTTFLP TAIKFHYVFN LRDLSNIFQG LLFSTAELLK SPLDLVRLWL HEAERVYGDK
MVDEKDQDTL RRVTMASTKK FFDLGDELLF ARPNIFCHFA QGIGESKYLS VTDVAYLNKL
LVDVLDSYNE VNAVMNLVLF EDAVAHICRI NRILESPRGN ALLVGVGGSG KQSLSRLAAF
ISALDVFQIT LKKGYGIPDL KVDLAAQYIK SAVKNVPSVF LMTDSQVSEE QFLVLMNDLL
ASGEIPGLFA DDEVENIIAS MRPQVKSLGV ADTREACWKF FIDKVRKQLK VILCFSPVGS
VLRVRARKFP AVVNCTAINW FHEWPEDALV SVSARFLQET PGIQPEVKAS ISLFMSYVHT
TVNEMSKVYL ATERRYNYTT PKTFLEQIKL YQNLLAKKRM ELAAKIERLD NGLMKLQSTA
SQVDDLKAKL AVQETELKQK NENADKLIQV VGVETEKVSK EKAIADEEEV KVPLGTAPSP
APSPCSVSPL VSSPCLCAPA NTLRKLESLG SAPDAVVNVT AAVMILTAPG GKIPKDKSWK
AAKIMMGKVD SFLDSLKRFD KEHIPEACLK AFKPYQGNPT FDPEFIRSKS TAAAGLCSWC
INIVRFYEVY CDVAPKRQAL EEANAELAEA QEKLSRIKNK IAVSLNANLN NLTSAFEKAT
AEKIKCQQEA DATNRVISLA NRLVGGLASE NVRWAESVES YKCQGATLCG DVLLVSAFVS
YVGYFTKKYR NELMEKFWIP YINNLKVPIP ITKGLDPLSL LTDDADVATW NNQGLPSDRM
STENATILCN TERWPLIVDA QLQGIKWIKN KYGGDLRAIR LGQKSYLDMI EQAVSEGDTL
LIENIGETVD PVLDPLLGRN TIKKGRFIKI GDKEVEYHPK FRLILHTKYF NPHYKPEMQA
QCTLINFLVT RDGLEDQLLA AVVAKERPDL EQLKANLTKS QNEFKIVLKE LEDSLLARLS
AASGHFLGDT ALVENLETTK HTASEIEEKV QEAKITETKI NEARENYRPA AERASLLYFI
LNDLSKINPI YQFSLKVGAP AAGAGRGGAG PRSPSPEPRL PRSPSPEPRL SWNFVEEKMG
SKFVEGRSVE FSKSYEESSP STPIFFILSP GVDPLKDVEA LGKKLGFTID NGKLHNVSLG
QGQEVVAENA LDVAAENGHW VILQNIHLVA RWLSTLDKKV ERYSTGSHED YRVFISAEPA
PSPEAHIIPQ GILENAIKIT NEPPTGMHAN LHKALDLFTQ DTLEMCTKEV EFKCILFALC
YFHAVVAERR KFGAQGWNRS YPFNNGDLTI SINVLYNYLE ANAKVRRLTS QGDWERRVRS
VHSAGADTDT GADTGTGADT GADTGVGTGA DTGTGASQVK AVLDDILEKI PEAFSMAEIM
AKAAEKTPYV VVAFQECERM NILTNEMRRS LKELSLGLKG ELTITTDMED LSTALFYDTV
PDTWVARAYP SMMGLAAWYA DLLLRIRELE AWTTDFALPT TVWLAGFFNP QSFLTAIMQS
MARKNEWPLD KMCLSVEVTK KNREDMTAPP REGAYVYGLF MEGARWDIQT GVIAEARLKE
LTPAMPVIFI KAIPVDRMET KNIYECPVYK TRLRGPTYVW TFNLKTKERA AKWILAAVAL
LLQV
//